Nimodipine in the treatment of old age dementias

Abnormalities of CSF flow patterns in the cerebral aqueduct in treatment‐resistant late‐life depression: A potential biomarker of microvascular angiopathy

“…In elderly patients, antihypertensive medication, which has a significant effect on pulse pressure, has been shown to produce significant cognitive improvement compared to equivalent therapy that produces a reduction in blood pressure but a smaller decrease in the pulse pressure (39). Furthermore, nimodipine treatment for established dementia in the elderly showed a clear therapeutic benefit with improvements in cognitive and memory function, and global improvement in the Hamilton psychiatric rating scale for depression, and nimodipine augmentation of antidepressants led to improved outcomes for nondemented patients with depressive disorder (37,40). It has been suggested that new antihypertensive agents should be developed that specifically target changes in pulse pressure (34).…”

Beyond Lithium in the Treatment of Bipolar Illness

“…Seventeen of 33 (52%) patients responded to lamotrigine as marked or moderate on the CGI-BP. Again, both antidepressant and mood-stabilizing properties were evident in these pa- Ban et al 1990 87 patients on nimodipine, 88 patients on placebo -in elderly patients with cognitive decline, sig. more favorable changes in depressive symptomatology with nimodipine tients as compared with the placebo phase.…”

Antihypertensive Treatment in People With Dementia

“…One randomised controlled trial and one cohort study investigated the relationship between antihypertensive treatment and depression in people with dementia. The randomised controlled trial investigated the effect of Nimodipine (CCB) on depression in patients with diagnosed dementia as well as those with mild to moderate cognitive decline on the Global Deterioration scale 34 . The treatment and control group were allowed to use other medication including antihypertensive treatment.…”