The activities with potential to sustain new technology transfer offices (TTOs) within the publicly financed South African universities (PFSAU) and elsewhere are poorly examined. The current chapter thus aims to lay out a series of simple strategic activities which the referred universities can execute to ensure the sustainability of their newly formed TTOs. Data were collected via strategic conversations with intellectual property (IP) experts, and active academic researchers from PFSAU. The activities considered vital for the sustainability of newly formed TTOs in this study encompass extensive training of TTOs staff, IP awareness within and outside the universities, compliance with relevant legislations, learning from well-established TTOs, establishment of IP and innovation policy as well as IP and innovation modules, collaboration with formal and informal sectors outside the universities, execution of applied and industry-driven research by academics and finally, protection and commercialisation of IP. Overall, efficacious executions and implementations of these activities as discussed in the present study will not only contribute towards the sustainability of newly established TTOs within PFSAU but also aid in achieving some of this universities' shared goals such as community engagement, research with economic impact, teaching and learning. However, some of the referred activities can be achieved either over a short or medium periods, but together are crucial stepping stones to continual achievements of long-term goals of TTOs in PFSAU.