Niosomal Gel for Site-Specific Sustained Delivery of Anti-Arthritic Drug: In Vitro-In Vivo Evaluation

Kaur, Karandeep; Jain, Subheet Kumar; Sapra, Bharti; Tiwary, Ashok K.

doi:10.2174/156720107782151250

Cited by 29 publications

(17 citation statements)

References 22 publications

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“…The skin was removed, cut into small pieces, fixed, microtomed (5 μm thickness), and sections were fixed on glass slide. These sections were stained with eosin-hematoxylin and observed under optical microscope (DX 31, Olympus, Tokyo, Japan) for integrity and structural changes of epidermis (22).…”

Section: Skin Toxicity Studiesmentioning

confidence: 99%

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Drug-Cyclodextrin-Vesicles Dual Carrier Approach for Skin Targeting of Anti-acne Agent

2010

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Abstract. In the present study attempt was made for preparation of isotretinoin-hydroxypropyl β cyclodextrin (HP-β-CD) inclusion complex and encapsulate this complex in elastic liposomes to study the effect of dual carrier approach on skin targeting of isotretinoin. The isotretinoin HP-β-CD complex was prepared by freeze-drying method and characterized by IR spectroscopy. The drug and drug-CD complex loaded elastic liposomal formulation were prepared and characterized in vitro, ex-vivo and in vivo for shape, size, entrapment efficiency, no. of vesicles per cubic mm, in vitro skin permeation and deposition study, photodegradation and skin toxicity assay. The transdermal flux for different vesicular formulations was observed between 10.5±0.5 to 13.9±1.6 μg/cm 2 /h. This is about 15-21 folds higher than that obtained from drug solution (0.7 ±0.1 μg/cm 2 /h) and 4-5 folds higher than obtained with drug-CD complex solution (2.7±0.1 μg/cm 2 /h). The amount of drug deposit was found to increase significantly (p<0.05) by cyclodextrin complexation (30.1±0.1 μg). The encapsulation of this complex in elastic liposomal formulation further increases its skin deposition (262.2 ±21 μg). The results of skin irritation study using Draize test also showed the significant reduction in skin irritation potential of isotretinoin elastic liposomal formulation in comparison to free drug. The results of the present study demonstrated that isotretinoin elastic liposomal formulation possesses great potential for skin targeting, prolonging drug release, reduction of photodegradation, reducing skin irritation and improving topical delivery of isotretinoin.

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Section: Skin Toxicity Studiesmentioning

confidence: 99%

“…Phosphatidylcholine is used as bilayer forming agent. Niosomes was used as control and prepared by optimized composition as reported by our group (22). Niosomes consist of non-ionic surfactant as bilayer forming agent along with cholesterol and PC as stabilizing agent.…”

Section: Preparation Of Elastic Liposomal Formulationsmentioning

confidence: 99%

Drug-Cyclodextrin-Vesicles Dual Carrier Approach for Skin Targeting of Anti-acne Agent

2010

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“…[13][14][15][16][17][18] Microemulsions are thermodynamically stable transparent (translucent) dispersions of oil and water stabilized by an interfacial film of surfactant and cosurfactant molecules having the droplet size less than 100 nm. [13] Studies have shown that microemulsion formulations possess improved transdermal and dermal delivery properties in vitro and in vivo [13][14][15][16][17][18] over other colloidal drug delivery systems that include self-microemulsifying drug delivery systems, [19] niosomes, [20] nanoemulsions, [21] solid dispersions, [22] cyclodextrin complex, [23,24] aerosols, [25] polymeric dispersions. [26] The aim of the present study was to prepare and characterize microemulsions formulation for sustained and site-specific delivery of celecoxib.…”

Section: Introductionmentioning

confidence: 99%

Celecoxib Solubilization in Nonionic Microemulsions

Fanun

2010

Journal of Dispersion Science and Technology

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In this study, we report on the solubilization of celecoxib, a pharmaceutical active ingredient in the U-type microemulsions formulated using sucrose monolaurate and peppermint oil. Ethanol was used as the cosurfactant. The aqueous phase consisted of water þ propylene glycol at a weight ratio equals two. The solubilization capacity of celecoxib in the formulated microemulsions along the water dilution line N60 where the surfactant/oil/ethanol weight ratio equals 3/1/1 is many times higher than in either the oil or the aqueous phase. The solubilized celecoxib does not affect the extent of water solubilization in the microemulsions. The celecoxib solubilization capacity decreases with the increase in the water content. We evaluated the microemulsions dilution and interfacial factors contributing to the celecoxib solubilization along the N60 dilution line. It was found that the dilution factor is dominant in determining the solubilization capacity of celecoxib when structural transitions are occurring. In an established microstructure, the interfacial factor is dominant. Structural transition of celecoxib loaded water-in-oil microemulsion to a bicontinuous phase and to oil-in-water droplets were identified using SAXS measurements along the N60 dilution line. It was found that below 30 wt% aqueous phase content the water-in-oil microemulsions are present, the transition between the water-in-oil to bicontinuous and then to oil-in water microemulsions occur at 30 and 75 wt% aqueous phase, respectively. SAXS measurements demonstrated that the drug effects the structure of microemulsion droplets and forms ''ill-defined structures,'' probably less spherical. Yet, the overall droplet sizes at the high dilutions did not change very much. The results demonstrate that the solubilized drug affects the transition from bicontinuous to water-in-oil microemulsions. The hydrodynamic radius of the drug loaded microemulsions at 80 and 90 wt% aqueous phase content was determined by dynamic light scattering.

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“…Their percutaneous absorption across exercised rat skin showed greater flux compared with the nonelastic niosomes. The application of pMEL34-loaded elastic cationic niosomes in melanoma cell lines gave four times increase in tyrosinase gene expression compared with the free and the plasmid in nonelastic niosomes which lead to efficient topical delivery in vitiligo therapy [103]. Tretinoin (vitamin A metabolite), is topically applied for the treatment of skin diseases such as acne, psoriasis, and photoaging.…”

Section: Niosomes For Transdermal Delivery Of Drugsmentioning

confidence: 99%

Hydrogels and Their Combination with Liposomes, Niosomes, or Transfersomes for Dermal and Transdermal Drug Delivery

Ibrahim¹,

Nair²,

Al‐Dhubiab³

et al. 2017

Liposomes

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Polymeric networks that retain and absorb substantial amount of water or biological fluids and resemble as a biological tissue are defined as hydrogels. On the other hand, liposomes, transfersomes and niosomes are lipid carriers, which represent one of the major research and development focus areas of the pharmaceutical industry. They have great potential as lipid vehicles that are able to enhance permeation of drugs across the intact skin and can act as local depot for the drug to sustain and control its delivery. Lipid carrier and hydrogel combinations offer transdermal drug delivery of great potential to enhance systemic effects of both hydrophilic and lipophilic drugs. Also, lipid carriers can target drugs to skin appendages and improve transdermal delivery. Lipid carrier proform systems in the form of gelly liquid crystals can also be used transdermally for better drug absorption enhancement. This review highlights the potential of hydrogels and emulgels with or without lipid nanocarriers for dermal and transdermal application.

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Niosomal Gel for Site-Specific Sustained Delivery of Anti-Arthritic Drug: In Vitro-In Vivo Evaluation

Cited by 29 publications

References 22 publications

Drug-Cyclodextrin-Vesicles Dual Carrier Approach for Skin Targeting of Anti-acne Agent

Drug-Cyclodextrin-Vesicles Dual Carrier Approach for Skin Targeting of Anti-acne Agent

Celecoxib Solubilization in Nonionic Microemulsions

Hydrogels and Their Combination with Liposomes, Niosomes, or Transfersomes for Dermal and Transdermal Drug Delivery

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