Niosome-based hydrogel of resveratrol for topical applications: An effective therapy for pain related disorder(s)

Negi, Poonam; Aggarwal, Madhur; Sharma, Gajanand; Rathore, Charul; Sharma, Gaurav; Singh, Bhupinder; Katare, Om Prakash

doi:10.1016/j.biopha.2017.01.083

Cited by 75 publications

(38 citation statements)

References 25 publications

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“…Moreover, the skin retention for the niosomal gel was found to be 4.76±0.21 mg/cm 2 , which corresponded to almost five times the value observed with plain drug suspension. Dermatokinetic studies confirmed the high RSV permeability in dermis and epidermis and the increase of its biological half‐life using niosomal hydrogel …”

Section: Overcoming Limitationsmentioning

confidence: 71%

“…Finally, in vivo pharmacodynamic study showed that the percentage of inhibition in paw oedema from RSV encapsulated in niosomal hydrogel, was comparable with a commercial formulation (diclofenac Sodium), albeit the former displayed a prolonged therapeutic action …”

Section: Potential Applicationsmentioning

confidence: 89%

“…The combination of several approaches to obtained new carriers constitutes also an interesting alternative to previously mentioned systems are. For instance, Negi and co‐workers designed a topical RSV delivery system combining niosomes and hydrogels for treatment of pain disorders . The hydrogel matrix was prepared with Carbopol® 934, due to its hydrophilic and bio‐adhesive properties, whereas the niosomes were prepared by TFH using a mixture of Span 80 and cholesterol.…”

Section: Delivery Systemsmentioning

confidence: 99%

“…In this sense, 90 % of RSV was released over 6 h, being only slightly slower from the niosomal hydrogel compared to a suspension formulation. Among different mathematical models, the Korsmeyer‐Peppas kinetic model provided the best fitting for both niosomal and suspension formulations …”

Section: Overcoming Limitationsmentioning

confidence: 99%

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Recent Strategies in Resveratrol Delivery Systems

2019

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Resveratrol, a natural polyphenolic stilbenoid widely found in grapes and wines, displays beneficial properties such as cardio‐protective, antioxidant and anti‐inflammatory activities. Trans‐resveratrol (RSV) is the most bioactive and more abundant stereoisomer found in nature. Despite the positive properties of RSV, there are various factors that limit its effectiveness, including low aqueous solubility, low oral bioavailability and chemical instability. During the last years, an increasing number of strategies such as nano and micro encapsulation have been developed in order to overcome these limitations and enhance the use of RSV in nutritional and pharmaceutical applications. This Review summarizes the advances and main properties of several RSV carriers and delivery systems reported during the last 5 years.

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Section: Overcoming Limitationsmentioning

confidence: 71%

Section: Potential Applicationsmentioning

confidence: 89%

Section: Delivery Systemsmentioning

confidence: 99%

Section: Overcoming Limitationsmentioning

confidence: 99%

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Recent Strategies in Resveratrol Delivery Systems

2019

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“…However, the therapeutic potential of resveratrol is limited because of its poor bioavailability, low water solubility, chemical instability, and limited skin permeability [93,94]. Recently, a resveratrol-loaded niosomal hydrogel system, which could enhance the permeation and deposition of resveratrol in skin, had been developed by Negi et al Administration of this niosomal gel reduced edema with prolonged therapeutic action, as evaluated with a model of edema induced in rat paw by carrageenan injection [95].…”

Section: Inflammationmentioning

confidence: 99%

Niosomes: a review of their structure, properties, methods of preparation, and medical applications

et al. 2017

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Target-specific drug-delivery systems for the administration of pharmaceutical compounds enable the localization of drugs to diseased sites. Various types of drug-delivery systems utilize carriers, such as immunoglobulins, serum proteins, synthetic polymers, liposomes, and microspheres. The vesicular system of niosomes, with their bilayer structure assembled by nonionic surfactants, is able to enhance the bioavailability of a drug to a predetermined area for a period. The amphiphilic nature of niosomes promotes their efficiency in encapsulating lipophilic or hydrophilic drugs. Other additives, such as cholesterol, can be used to maintain the rigidity of the niosomes' structure. This narrative review describes fundamental aspects of niosomes, including their structural components, methods of preparation, limitations, and current applications to various diseases.

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Green preparation and evaluation of the anti‐psoriatic activity of vesicular elastic nanocarriers of kojic acid from Aspergillus oryzae N12: Repurposing of a dermo‐cosmetic lead

Moussa,

Abbas,

Zewail

et al. 2024

Archiv der Pharmazie

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Psoriasis is a skin disorder characterized by impaired epidermal differentiation that is regularly treated by systemic drugs with undesirable side effects. Based on its anti‐inflammatory, antiproliferative and anti‐melanoma attributes, the fungal metabolite kojic acid represents an attractive candidate for anti‐psoriatic research. The present work aims to investigate an efficient topical bio‐friendly vesicular system loaded with kojic acid isolated from Aspergillus oryzae as an alternative way for the management of psoriasis to avoid systemic toxicity. Kojic acid‐loaded spanlastics were prepared by ethanol injection technique, employing span 60 along with brij 35 and cremophor rh40 as edge activators, with the complete in vitro characterization of the developed nanoplatform. The selected formulation displayed a spherical morphology, an optimum particle size of 234.2 ± 1.65 nm, high entrapment efficiency (87.4% ± 0.84%) and significant sustained drug release compared with the drug solution. In vivo studies highlighted the superior relief of psoriasis symptoms and the ability to maintain healthy skin with the least changes in mRNA expression of inflammatory cytokines, achieved by the developed nanoplatform compared to kojic acid solution. Moreover, the in vivo histopathological studies confirmed the safety of the topically applied spanlastics. In addition, the molecular mechanism was approached through in vitro assessment of cathepsin S and PDE‐4 inhibitory activities and in silico investigation of kojic acid docking in several anti‐psoriatic drug targets. Our results suggest that a topically applied vesicular system loaded with kojic acid could lead to an expansion in the dermo‐cosmetic use of kojic acid as a natural bio‐friendly alternative for systemic anti‐psoriatic drugs.

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Niosome-based hydrogel of resveratrol for topical applications: An effective therapy for pain related disorder(s)

Cited by 75 publications

References 25 publications

Recent Strategies in Resveratrol Delivery Systems

Recent Strategies in Resveratrol Delivery Systems

Niosomes: a review of their structure, properties, methods of preparation, and medical applications

Green preparation and evaluation of the anti‐psoriatic activity of vesicular elastic nanocarriers of kojic acid from Aspergillus oryzae N12: Repurposing of a dermo‐cosmetic lead

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