Niosomes: a novel targeted drug delivery system for cancer

Moghtaderi, Maryam; Sedaghatnia, Kamand; Bourbour, Mahsa; Fatemizadeh, Mahdi; Moghaddam, Zahra Salehi; Hejabi, Faranak; Heidari, Fatemeh; Quazi, Sameer; Far, Bahareh Farasati

doi:10.1007/s12032-022-01836-3

Cited by 55 publications

(32 citation statements)

References 162 publications

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“…They may target various cancer cell pathways and processes with several drugs, improving effectiveness and overcoming multidrug resistance. 212 These systems shield the transported chemicals from degradation and clearance, improve their solubility and permeability, and target the tumor location to release medications in a controlled manner. 213 This increases the stability and delivery efficiency and minimizes the therapeutic drug dose and frequency, preventing effects on normal tissues and organs.…”

Section: Challenges and Future Directionsmentioning

confidence: 99%

Composition, preparation methods, and applications of nanoniosomes as codelivery systems: a review of emerging therapies with emphasis on cancer

Roostaee,

Derakhshani,

Mirhosseini

et al. 2024

Nanoscale

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Section: Challenges and Future Directionsmentioning

confidence: 99%

Composition, preparation methods, and applications of nanoniosomes as codelivery systems: a review of emerging therapies with emphasis on cancer

Roostaee,

Derakhshani,

Mirhosseini

et al. 2024

Nanoscale

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“…Niosomal formulations are biocompatible, exhibit non-immunogenic properties, and can encapsulate both hydrophilic and hydrophobic active compounds. These lipid-based carriers have also shown better penetrating potential and stability than liposomes [ 85 , 86 ]. Studies support that the combination of niosomes and polymeric systems possesses proper antibacterial activity and promising characteristics [ 87 , 88 ].…”

Section: Mechanism Of Lipid-based Drug Delivery Systemsmentioning

confidence: 99%

Combinational System of Lipid-Based Nanocarriers and Biodegradable Polymers for Wound Healing: An Updated Review

Far

Naimi-Jamal

Sedaghat

et al. 2023

JFB

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Skin wounds have imposed serious socioeconomic burdens on healthcare providers and patients. There are just more than 25,000 burn injury-related deaths reported each year. Conventional treatments do not often allow the re-establishment of the function of affected regions and structures, resulting in dehydration and wound infections. Many nanocarriers, such as lipid-based systems or biobased and biodegradable polymers and their associated platforms, are favorable in wound healing due to their ability to promote cell adhesion and migration, thus improving wound healing and reducing scarring. Hence, many researchers have focused on developing new wound dressings based on such compounds with desirable effects. However, when applied in wound healing, some problems occur, such as the high cost of public health, novel treatments emphasizing reduced healthcare costs, and increasing quality of treatment outcomes. The integrated hybrid systems of lipid-based nanocarriers (LNCs) and polymer-based systems can be promising as the solution for the above problems in the wound healing process. Furthermore, novel drug delivery systems showed more effective release of therapeutic agents, suitable mimicking of the physiological environment, and improvement in the function of the single system. This review highlights recent advances in lipid-based systems and the role of lipid-based carriers and biodegradable polymers in wound healing.

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“…In the last few years, there have been numerous efforts to develop a new VCR formulation with fewer adverse effects and greater therapeutic value. Liposomes, nanoparticles, micelles, and microspheres are only some of the drug delivery platforms used for this purpose, with varied but generally encouraging outcomes 13 , 14 . Liu et al synthesized VCR-Au conjugated nanoparticles entrapped in liposome, enhancing anti-tumor efficiency.…”

Section: Introductionmentioning

confidence: 99%

Multi-responsive chitosan-based hydrogels for controlled release of vincristine

et al. 2023

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As medical research progresses, the derivation and development of biological materials such as hydrogels have steadily gained more interest. The biocompatibility and non-toxicity of chitosan make chitosan hydrogels potential carriers for drug delivery. This work aims to develop two multi-reactive, safe, and highly swellable bio-hydrogels consisting of chitosan-graft-glycerol (CS-g-gly) and carboxymethyl chitosan-graft-glycerol (CMCS-g-gly), for sustained and controlled drug release, improved bioavailability along with entrapment in nanocarriers, which reduces side effects of vincristine sulphate. CS-g-gly and CMCS-g-gly are successfully prepared and fully characterized using analytical techniques. Under various conditions, the prepared hydrogels exhibit a high swelling ratio. Vincristine-loaded CS-g-gly (VCR/CS-g-gly), and CMCS-g-gly (VCR/CMCS-g-gly) show high encapsulation efficiency between 72.28-89.97%, and 56.97-71.91%, respectively. VCR/CS-g-gly show a sustained release behavior, and the maximum release of VCR from hydrogels reached 82% after 120 h of incubation. MCF-7 (breast cancer cell line) and MCF-10 (normal breast cell line) are evaluated for cell viability and apoptosis induction. The in-vitro anti-tumor efficacy is investigated using flow cytometry. The tetrazolium-based MTT assay of hydrogels shows no evidence of significant cytotoxicity in MCF-7 and MCF-10 cells. According to these findings, these hydrogels can effectively deliver drugs to MCF-7 and other breast cancer cells.

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Niosomes: a novel targeted drug delivery system for cancer

Cited by 55 publications

References 162 publications

Composition, preparation methods, and applications of nanoniosomes as codelivery systems: a review of emerging therapies with emphasis on cancer

Composition, preparation methods, and applications of nanoniosomes as codelivery systems: a review of emerging therapies with emphasis on cancer

Combinational System of Lipid-Based Nanocarriers and Biodegradable Polymers for Wound Healing: An Updated Review

Multi-responsive chitosan-based hydrogels for controlled release of vincristine

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