Nipah virus infection: A review

Aditi, Aditi; Shariff, Malini

doi:10.1017/s0950268819000086

Cited by 114 publications

(118 citation statements)

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“…Nipah virus is an emerging pathogen identified 20 years ago in Malaysia and has since caused outbreaks in other parts of South and Southeast Asia. 24 It is highly lethal and is highly infectious. For the Streptococcus bacteria we considered the dysgalactiae and suis strains.…”

Section: Experimental Evaluation and Results Analysismentioning

confidence: 99%

Discovering genomic patterns in SARS‐CoV‐2 variants

D’Angelo

Palmieri

2020

Int J Intell Syst

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SARS‐CoV‐2 is a novel severe acute respiratory syndrome‐like coronavirus (SARS‐CoV), which is responsible of the ongoing world pandemic of COVID‐19 disease. Although many approaches are being investigated to address this issue, nowaday there are no vaccines available and there is little evidence supporting the efficiency of potential therapeutic agents. Moreover, the high mutation rate of this virus heavily affects the understanding of its evolution and diffusion mechanisms, and, in turn, the development of effective solutions. In this study, two novel algorithms are provided for finding out recurrent patterns of nucleotide subsequences of different SARS‐CoV‐2 genomes as a unique signature capable of identifying the most peculiar features of the pathogen. In particular, we provide several subsequence patterns related to the Spike glycoprotein, which is believed to be the main target for developing effective drugs and vaccines against the COVID‐19 disease because of its role in the entrance of coronaviruses into host cells. The experimental results, obtained by analyzing 5000 genomes of SARS‐CoV‐2, have shown that the extracted patterns are able to recognize the Spyke protein in the 99.35% of the considered genomes. In addition, such patterns have proven to be highly discriminating with respect to other pathogenic genomes, such as SARS, Middle East respiratory syndrome, Nipah, and the streptococcus bacteria. We hope that the findings presented in this study can help specialists in speeding up the design of more accurate drugs or vaccines against SARS‐CoV‐2.

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Section: Experimental Evaluation and Results Analysismentioning

confidence: 99%

Discovering genomic patterns in SARS‐CoV‐2 variants

D’Angelo

Palmieri

2020

Int J Intell Syst

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“…Nipah virus (NiV) infection is a newly emerging zoonosis that causes severe encephalitic and respiratory disease in humans. NiV infection has a high human case fatality rate estimated to be between 40 and 75% [1]. NiV is on the WHO list of emerging pathogens likely to cause severe outbreaks in the near future and for which few or no medical countermeasures exist, thus research is a priority [2].…”

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confidence: 99%

“…NiV is on the WHO list of emerging pathogens likely to cause severe outbreaks in the near future and for which few or no medical countermeasures exist, thus research is a priority [2]. Since the first outbreak and discovery of Nipah virus in Malaysia and Singapore at the end of the last century there have been outbreaks of Nipah virus infection in India or Bangladesh almost annually [1]. Flying foxes of the genus Pteropus are the reservoir for NiV and NiV can also infect pigs [1,3].…”

mentioning

confidence: 99%

“…Since the first outbreak and discovery of Nipah virus in Malaysia and Singapore at the end of the last century there have been outbreaks of Nipah virus infection in India or Bangladesh almost annually [1]. Flying foxes of the genus Pteropus are the reservoir for NiV and NiV can also infect pigs [1,3]. Initial outbreaks of NiV Malaysian variant were likely to be due to contact with infected pigs, but more recent outbreaks of NiV Bangladesh variant may be due to direct contact with bats or contact with or consumption of raw date palm sap contaminated by bats [1].…”

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confidence: 99%

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Survival and persistence of Nipah virus in blood and tissue culture media

Smither

Eastaugh

Findlay

et al. 2019

Emerging Microbes & Infections

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Nipah virus (NiV) infection is a newly emerging zoonosis that causes severe disease in humans. Nipah virus is one of the lesser studied of the WHO emerging pathogens for which research is a priority. Survival and persistence data is important for risk management and understanding the hazard of the virus for laboratory and health care workers that may work with the virus and we present some initial findings on the survival of Nipah virus in blood and tissue culture media under different conditions. The titre of Nipah virus in blood or media at two different temperatures and exposed or sealed to the atmosphere was measured every day for three days and after a week. Nipah virus was very stable in blood in closed tubes held at room temperature with minimal decay over seven days. Decay was observed in all the other conditions tested and was more rapid in samples exposed to the atmosphere. Persistence data is useful for safety planning and risk management.

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“…present a systematic review on Middle East Respiratory Syndrome Coronavirus with the aim of characterising the distribution and spread of infection in dromedary camels [5]. Aditi et al review the recent Nipah virus outbreaks in Bangladesh and India, shedding light on transmission patterns of this emerging pathogen while also highlighting the importance of ongoing surveillance [6]. A review analysis of H5N1 and H9N2 by Parvin et al .…”

mentioning

confidence: 99%