Nipah virus infection: current scenario

Kulkarni, D. D.; Tosh, C.; Venkatesh, Govindarajulu; Kumar, Deepak

doi:10.1007/s13337-013-0171-y

Cited by 113 publications

(124 citation statements)

References 73 publications

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“…While in case of Bangladesh and Indian NiV outbreaks, epidemiology was comparatively less well defined. NiV infect the human through the flying foxes and without the involvement of pigs while some evidences indicated person‐to‐person transmission of NiV …”

Section: Epidemiology Of Nipah Virusmentioning

confidence: 99%

“…Various steps including ban on pig transport, public education, national surveillance, and pig culling were taken to control NiV outbreak. Pig farming is one of top industries in Malaysia, and more than one million pigs were culled during NiV outbreaks, resulted in an economic loss between $350 and $400 million . The NiV infection spread to Singapore due to import of infected pigs from infected area of Malaysia.…”

Section: Nipah Virus Outbreaks (1998‐2018)mentioning

confidence: 99%

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Emerging trends of Nipah virus: A review

Sharma

Kumar

Yadav

et al. 2018

Reviews in Medical Virology

151

129

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Summary Since emergence of the Nipah virus (NiV) in 1998 from Malaysia, the NiV virus has reappeared on different occasions causing severe infections in human population associated with high rate of mortality. NiV has been placed along with Hendra virus in genus Henipavirus of family Paramyxoviridae. Fruit bats (Genus Pteropus) are known to be natural host and reservoir of NiV. During the outbreaks from Malaysia and Singapore, the roles of pigs as intermediate host were confirmed. The infection transmitted from bats to pigs and subsequently from pigs to humans. Severe encephalitis was reported in NiV infection often associated with neurological disorders. First NiV outbreak in India occurred in Siliguri district of West Bengal in 2001, where direct transmission of the NiV virus from bats‐to‐human and human‐to‐human was reported in contrast to the role of pigs in the Malaysian NiV outbreak. Regular NiV outbreaks have been reported from Bangladesh since 2001 to 2015. The latest outbreak of NiV has been recorded in May, 2018 from Kerala, India which resulted in the death of 17 individuals. Due to lack of vaccines and effective antivirals, Nipah encephalitis poses a great threat to public health. Routine surveillance studies in the infected areas can be useful in detecting early signs of infection and help in containment of these outbreaks.

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Section: Epidemiology Of Nipah Virusmentioning

confidence: 99%

Section: Nipah Virus Outbreaks (1998‐2018)mentioning

confidence: 99%

Emerging trends of Nipah virus: A review

Sharma

Kumar

Yadav

et al. 2018

Reviews in Medical Virology

151

129

View full text Add to dashboard Cite

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“…Following this initial outbreak, NiV re-emerged separately in Bangladesh (Arankalle et al 2011; Hsu et al 2004; Rahman & Chakraborty 2012), and in Siliguri, India (Chadha et al 2006), both during 2001. NiV has subsequently re-emerged almost every year in Bangladesh, with frequent outbreaks also documented in India (Islam et al 2016; Kulkarni et al 2013; Luby et al 2009). These outbreaks differ from the first – Malaysian – NiV outbreak in that transmission appears to occur directly from the bat reservoir to humans, primarily via consumption of date palm sap contaminated with urine or saliva from infected bats (Islam et al 2016; Luby et al 2006; Openshaw et al 2016; Rahman et al 2012).…”

Section: Known Highly Lethal Emergent Paramyxoviruses: Nipah Virusmentioning

confidence: 99%

Zoonotic Potential of Emerging Paramyxoviruses

Thibault

Watkinson

Moreira-Soto

et al. 2017

Advances in Virus Research

113

102

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The risk of spillover of enzootic paramyxoviruses, and the susceptibility of recipient human and domestic animal populations, are defined by a broad collection of ecological and molecular factors that interact in ways that are not yet fully understood. Nipah and Hendra viruses were the first highly-lethal zoonotic paramyxoviruses discovered in modern times, but other paramyxoviruses from multiple genera are present in bats and other reservoirs that have unknown potential to spill over into humans. We outline our current understanding of paramyxovirus reservoir hosts and the ecological factors that may drive spillover, and we explore the molecular barriers to spillover that emergent paramyxoviruses may encounter. By outlining what is known about enzootic paramyxovirus receptor usage, mechanisms of innate immune evasion, and other host-specific interactions, we highlight the breadth of unexplored avenues that may be important in understanding paramyxovirus emergence.

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“…This well-described 1999 outbreak resulted in illness in 283 persons (mainly hog farm workers), 109 deaths, and the destruction of 1.1 million pigs (Chua 2003;Kulkarni et al 2013). Less well known is that near annual outbreaks occur in Bangladesh associated with viral transmission from uncooked date palm sap contaminated with the saliva of Pteropus fruit bats (Kulkarni et al 2013), a natural host of Nipah and several other zoonotic viruses.…”

Section: Malaysian Nipah Virus Outbreakmentioning

confidence: 99%

“…Less well known is that near annual outbreaks occur in Bangladesh associated with viral transmission from uncooked date palm sap contaminated with the saliva of Pteropus fruit bats (Kulkarni et al 2013), a natural host of Nipah and several other zoonotic viruses. In addition to being a disease of great public health importance, the Malaysian Nipah outbreak disrupted the wet-market food supply and livelihoods of local farmers.…”

Section: Malaysian Nipah Virus Outbreakmentioning

confidence: 99%

Genomics, animal models, and emerging diseases: relevance to One Health and food security

Harding

2015

Genome

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The One Health concept is a worldwide strategy for expanding interdisciplinary collaborations and communications in all aspects of health care for humans, animals, and the environment (Kahn 2015). But what does this really mean and how does One Health relate to how health care professionals, veterinarians, and researchers respond to emerging infectious diseases in human and livestock populations? The purpose of this presentation is to place One Health in context with a number of current and historic scenarios and will highlight how animal disease researchers working with the Canadian pork industry are using animal models and 'omic technologies to protect food security, improve food safety, and investigate emerging diseases for the mutual benefit of animal and public health.

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Nipah virus infection: current scenario

Abstract: The emergence of Nipah virus (NiV)

Cited by 113 publications

References 73 publications

Emerging trends of Nipah virus: A review

Emerging trends of Nipah virus: A review

Zoonotic Potential of Emerging Paramyxoviruses

Genomics, animal models, and emerging diseases: relevance to One Health and food security

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