Nipple sparing subcutaneous mastectomy: Sixty-six months follow-up

Caruso, Francesco; Ferrara, M; Castiglione, G.; Trombetta, G.; Meo, L. De; Catanuto, Giuseppe; Carillio, Guido

doi:10.1016/j.ejso.2006.05.013

Cited by 145 publications

(114 citation statements)

References 25 publications

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“…The rate of local recurrence in numerous studies of patients undergoing an NSM varies, ranging from 0-25.7% (18,19,23,24). In the studies demonstrating rates of local recurrence >10%, cancer recurrence in the lymph nodes was included in the rate (19,24).…”

Section: Discussionmentioning

confidence: 99%

“…The rate of occult malignancy detected in the NAC in mastectomy specimens has varied widely with studies reporting an incidence of 1-31% (12)(13)(14)(15)(16). Over the years, a number of prospective and retrospective studies have demonstrated a cancer recurrence rate in the NAC of up to 2%, with local recurrence rates ranging from 1-6% (17)(18)(19). A more recent meta-analysis comparing NSM to skin-sparing mastectomy (SSM) and/or modified radical mastectomy (MRM) identified no difference in overall survival, disease free survival or local recurrence amongst the groups in properly selected patients with early stage breast cancer (20).…”

Section: Introductionmentioning

confidence: 99%

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Nipple-sparing mastectomies: Clinical outcomes from a single academic institution

Dull

Conant

Myckatyn

et al. 2017

Molecular and Clinical Oncology

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Abstract. Nipple-sparing mastectomies (NSMs) are increasingly used in the surgical treatment of patients with breast cancer and for prevention of breast cancer. The present study was performed to review the outcomes of patients undergoing NSMs at a single large university setting. A retrospective chart review was performed on all patients undergoing NSMs from 2008-2014. Charts were reviewed for demographic data and patient characteristics. Tumor and breast size, cancer recurrence and complications were also evaluated. Descriptive statistics were utilized to summarize the findings. From 2008From -2014 NSMs. The mean patient age was 44.4 years (range, 20-77). The average body mass index was 24 (range, 18-47). Breast weight was available for 106 specimens, with a mean weight of 475.5 g (range, 124.1-1,625.0 g). Seventy-three NSMs were performed for cancer and 124 were performed prophylactically. The mean tumor width was 1.38 cm (range, 0-6.0 cm), with an average nipple to tumor distance of 5.87 cm (range, 2.93-10.0 cm). Three (4%) patients required removal of the nipple areolar complex (NAC) due to pathological extension of the tumor. A total of 34 (17.2%) complications occurred, including infections, hematomas and nipple necrosis, with 9 requiring removal of the NAC and 13 requiring removal of the tissue expander or implant. Smokers had a 36.0% (9/25) complication rate, compared with 14.5% (25/172) of nonsmokers (P<0.05). During follow-up, one recurrence was noted, located on the chest wall. There were no recurrences in the NAC group. Therefore, NSMs may safely be performed without compromising oncologic outcomes or increasing complication rates in properly selected patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nipple-sparing mastectomies: Clinical outcomes from a single academic institution

Dull

Conant

Myckatyn

et al. 2017

Molecular and Clinical Oncology

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“…approach ranges between 2% and 67% (9,13,(16)(17)(18)(19)(20)(21)(22). A potential rationale for the wide divergence in the nipple necrosis outcomes stems from the variability in surgical methodology; in some cases, outcomes with both autologous and expander implant-based reconstructions were combined.…”

Section: Introductionmentioning

confidence: 99%

The effect of incision choice on outcomes of nipple-sparing mastectomy reconstruction

Rawlani¹,

Fiuk²

2011

J Plastic Surgery

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“…LR ranged from 2% to 24%, while DR ranged from 1.4% to 20%. Overall patient survival ranged from 76.4% to 100% [13,[22][23][24]. Benediktsson and Perbeck [23] reported much higher LR and DR rates, and the lower overall survival compared to other studies was due to subcutaneous mastectomy being used, which the authors attributed to comparatively reduced rates of adjuvant radiation use.…”

Section: Oncologic Safetymentioning

confidence: 86%

Skin-, nipple-, and areola-sparing mastectomy

Umoh

Arora

Simmons

2008

Breast Cancer Online

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Surgical management of breast carcinoma has evolved to include more breast conserving techniques such as skin-, nipple-, and areola-sparing mastectomies, as improved cosmesis becomes an increasing concern. However, the oncologic risk of these procedures must be strongly considered before such techniques can be widely adopted. Here we review available literature on these techniques and their associated clinical outcome. From our own experience, as well as from that reported, we conclude that nipple-, skin-, and areola-sparing mastectomies in carefully selected patients can have safe oncologic outcomes comparable to more traditional surgical techniques and therefore may be a feasible option for breast cancer management.

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Nipple sparing subcutaneous mastectomy: Sixty-six months follow-up

Cited by 145 publications

References 25 publications

Nipple-sparing mastectomies: Clinical outcomes from a single academic institution

Nipple-sparing mastectomies: Clinical outcomes from a single academic institution

The effect of incision choice on outcomes of nipple-sparing mastectomy reconstruction

Skin-, nipple-, and areola-sparing mastectomy

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