NIR-activated multi-hit therapeutic Ag2S quantum dot-based hydrogel for healing of bacteria-infected wounds

Du, Ting; Xiao, Zehui; Cao, Jiangli; Wei, Lifei; Li, Chunqiao; Jiao, Jingbo; Song, Zhiyong; Liu, Jifeng; Du, Xinjun; Wang, Shuo

doi:10.1016/j.actbio.2022.04.013

Cited by 38 publications

(26 citation statements)

References 69 publications

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“…It has been reported that a certain concentration of silver-based nanomaterials could kill all bacteria and fungi in the liquid environment. 57,58 We speculate that it is this high biocompatibility and antimicrobial properties of silver-based nanomaterials over a range of concentrations that make the cytotoxicity of Ag 2−3x Bi x S QDs relatively time-independent and internalization-independent. However, the groups that combined laser exposure and incubation with Ag 2−3x Bi x S QDs acted efficiently to kill cancer cells.…”

Section: Photothermal Performance Of Ag 2−3x Bimentioning

confidence: 99%

Ag_2–3xBi_xS Quantum Dots as Single-Component Theranostic Agents for Second Near-Infrared Fluorescence Imaging-Guided Photothermal Therapy

Cui

Han

Jiang

et al. 2023

ACS Appl. Nano Mater.

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Silver sulfide (Ag 2 S) nanomaterials are being researched increasingly because of their multifunctional potential in the second near-infrared (NIR-II) region (1000−1500 nm). Here, we report Ag 2−3x Bi x S quantum dots (Ag 2−3x Bi x S QDs) as single-component theranostic nanomaterials for NIR-II fluorescence imaging and synchronous photothermal therapy. Bismuth doping in Ag 2 S QDs leads to a fluorescence red shift to the NIR-II region and simultaneously enhances the photothermal conversion efficiency to 58.9%, which can be ascribed to the altered band gap introduced by bismuth doping. This Ag 2 S-based NIR-II theranostic agent can be synthesized in a controlled manner by an albumin biomineralization method under mild conditions. The encapsulation of the biomacromolecular albumin endowed Ag 2−3x Bi x S QDs with greatly strengthened biocompatibility and stability. The survival rate of cancer cells was only 13% after irradiation with an 808 nm laser at a density of 1.2 W cm −2 for 10 min. Meanwhile, in vivo experiments have confirmed the desirable NIR-II fluorescence imaging capability of Ag 2−3x Bi x S QDs. Thus, this study provides a highly efficient single-component theranostic agent with great promise for application in the field of precision theranostics.

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Section: Photothermal Performance Of Ag 2−3x Bimentioning

confidence: 99%

Ag_2–3xBi_xS Quantum Dots as Single-Component Theranostic Agents for Second Near-Infrared Fluorescence Imaging-Guided Photothermal Therapy

Cui

Han

Jiang

et al. 2023

ACS Appl. Nano Mater.

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“…The core–shell nanostructure of biomimetic virus-like mesoporous silica-coated Ag nanocubes entrapped in a hydrogel dressing is more capable of effectively adsorbing on the rigid cell wall of both Escherichia coli and Staphylococcus aureus than antibacterial silver nanoparticles [ 128 ]. The incorporation of mesoporous silica-modified CuS nanoparticles [ 129 ] or Ag 2 S quantum dots [ 130 ] ( Figure 7 ) into the network structure of hydrogels was used to build a multi-modal therapeutic platform with the combined effects of hyperthermia, radical oxygen species, and metal ions released under near-infrared irradiation against Escherichia coli and methicillin-resistant Staphylococcus aureus .…”

Section: Application Of Mesoporous Material-loaded Composite Hydrogelsmentioning

confidence: 99%

Mesoporous Materials Make Hydrogels More Powerful in Biomedicine

Chen

Qiu

Xia

et al. 2023

Gels

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Scientists have been attempting to improve the properties of mesoporous materials and expand their application since the 1990s, and the combination with hydrogels, macromolecular biological materials, is one of the research focuses currently. Uniform mesoporous structure, high specific surface area, good biocompatibility, and biodegradability make the combined use of mesoporous materials more suitable for the sustained release of loaded drugs than single hydrogels. As a joint result, they can achieve tumor targeting, tumor environment stimulation responsiveness, and multiple therapeutic platforms such as photothermal therapy and photodynamic therapy. Due to the photothermal conversion ability, mesoporous materials can significantly improve the antibacterial ability of hydrogels and offer a novel photocatalytic antibacterial mode. In bone repair systems, mesoporous materials remarkably strengthen the mineralization and mechanical properties of hydrogels, aside from being used as drug carriers to load and release various bioactivators to promote osteogenesis. In hemostasis, mesoporous materials greatly elevate the water absorption rate of hydrogels, enhance the mechanical strength of the blood clot, and dramatically shorten the bleeding time. As for wound healing and tissue regeneration, incorporating mesoporous materials can be promising for enhancing vessel formation and cell proliferation of hydrogels. In this paper, we introduce the classification and preparation methods of mesoporous material-loaded composite hydrogels and highlight the applications of composite hydrogels in drug delivery, tumor therapy, antibacterial treatment, osteogenesis, hemostasis, and wound healing. We also summarize the latest research progress and point out future research directions. After searching, no research reporting these contents was found.

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“…The embedded Ag 2 S QDs acted as PTAs and continuously released Ag + from the hydrogel matrix, while the temperature rise-induced volume change during NIR laser irradiation could rapidly release Ag + , realizing the combination disinfection of three modes. [151] Tao et al reported a composite antibacterial hydrogel prepared by uniformly dispersing copper NPs (Cu NPs) in a matrix of methacrylate-modified gelatin (Gel-MA) and N,N-bis(acryloyl)cystamine (BACA). In vitro antibacterial experiments revealed that the Cu NP-embedded hydrogel exhibited better antibacterial effects on both E. coli and S. aureus, which may be attributed to the synergy of Cu 2+ and heat.…”

Section: Ptt-metal Ion Therapymentioning

confidence: 99%

Photothermal Hydrogels for Promoting Infected Wound Healing

Xie

Wang

et al. 2022

Macromolecular Bioscience

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Photothermal therapies (PTT), with spatiotemporally controllable antibacterial capabilities without inducing resistance, have shown encouraging prospects in the field of infected wound treatments. As an important platform for PTT, photothermal hydrogels exhibit attractive advantages in the field of infected wound treatment due to their excellent biochemical properties and have been intensively explored in recent years. This review summarizes the progress of the photothermal hydrogels for promoting infected wound healing. Three major elements of photothermal hydrogels, i.e., photothermal materials, hydrogel matrix, and construction methods, are introduced. Furthermore, different strategies of photothermal hydrogels in the treatment of infected wounds are summarized. Finally, the challenges and prospects in the clinical treatment of photothermal hydrogels are discussed.

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NIR-activated multi-hit therapeutic Ag2S quantum dot-based hydrogel for healing of bacteria-infected wounds

Cited by 38 publications

References 69 publications

Ag_2–3xBi_xS Quantum Dots as Single-Component Theranostic Agents for Second Near-Infrared Fluorescence Imaging-Guided Photothermal Therapy

Ag_2–3xBi_xS Quantum Dots as Single-Component Theranostic Agents for Second Near-Infrared Fluorescence Imaging-Guided Photothermal Therapy

Mesoporous Materials Make Hydrogels More Powerful in Biomedicine

Photothermal Hydrogels for Promoting Infected Wound Healing

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NIR-activated multi-hit therapeutic Ag2S quantum dot-based hydrogel for healing of bacteria-infected wounds

Cited by 38 publications

References 69 publications

Ag2–3xBixS Quantum Dots as Single-Component Theranostic Agents for Second Near-Infrared Fluorescence Imaging-Guided Photothermal Therapy

Ag2–3xBixS Quantum Dots as Single-Component Theranostic Agents for Second Near-Infrared Fluorescence Imaging-Guided Photothermal Therapy

Mesoporous Materials Make Hydrogels More Powerful in Biomedicine

Photothermal Hydrogels for Promoting Infected Wound Healing

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Product

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Ag_2–3xBi_xS Quantum Dots as Single-Component Theranostic Agents for Second Near-Infrared Fluorescence Imaging-Guided Photothermal Therapy

Ag_2–3xBi_xS Quantum Dots as Single-Component Theranostic Agents for Second Near-Infrared Fluorescence Imaging-Guided Photothermal Therapy