NIR‐II Responsive Hydrogel as an Angiogenesis Inhibition Agent for Tumor Microenvironment Reprogramming

Zhao, Senfeng; Zhang, Ling; Ouyang, Jun; Xu, Qianqian; Gao, Xinyu; Zeng, Zhaolin; Liu, You‐Nian

doi:10.1002/smll.202103003

Cited by 29 publications

(28 citation statements)

References 37 publications

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“…Compared to the first near-infrared (NIR-I) window (from 750 to 1,000 nm), the second near-infrared (NIR-II) window (from 1,000 to 1,350 nm) for photothermal therapy exhibits inherent advantages of the deeper tissue-penetration, lower light scattering and higher maximum permissible exposure ( Lin et al, 2017 ; Liu Y. et al, 2019 ; Liu G. et al, 2019 ; Tian et al, 2021 ). Thus, many attempts have been contributed to developing new NIR-II-triggered photothermal nanoagents with satisfactory PTT efficacy through oxygen vacancy engineering ( Han et al, 2018 ; Yin et al, 2018 ; Zhao et al, 2021 ; Zhou Z. et al, 2021 ). For example, Chen et al ( Han et al, 2018 ) created an oxygen-defective TiO 2− x layer onto the surface of TiO 2 nanosemiconductors through a facile aluminum-reduction strategy, thus constructing a crystalline-disordered core-shell structure (TiO 2 @TiO 2− x ) with black color.…”

Section: Vacancy Defective Nanomaterials-enhanced Phototherapy and Mu...mentioning

confidence: 99%

Vacancy defect-promoted nanomaterials for efficient phototherapy and phototherapy-based multimodal Synergistic Therapy

Xiong

Wang

et al. 2022

Front. Bioeng. Biotechnol.

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Phototherapy and multimodal synergistic phototherapy (including synergistic photothermal and photodynamic therapy as well as combined phototherapy and other therapies) are promising to achieve accurate diagnosis and efficient treatment for tumor, providing a novel opportunity to overcome cancer. Notably, various nanomaterials have made significant contributions to phototherapy through both improving therapeutic efficiency and reducing side effects. The most key factor affecting the performance of phototherapeutic nanomaterials is their microstructure which in principle determines their physicochemical properties and the resulting phototherapeutic efficiency. Vacancy defects ubiquitously existing in phototherapeutic nanomaterials have a great influence on their microstructure, and constructing and regulating vacancy defect in phototherapeutic nanomaterials is an essential and effective strategy for modulating their microstructure and improving their phototherapeutic efficacy. Thus, this inspires growing research interest in vacancy engineering strategies and vacancy-engineered nanomaterials for phototherapy. In this review, we summarize the understanding, construction, and application of vacancy defects in phototherapeutic nanomaterials. Starting from the perspective of defect chemistry and engineering, we also review the types, structural features, and properties of vacancy defects in phototherapeutic nanomaterials. Finally, we focus on the representative vacancy defective nanomaterials recently developed through vacancy engineering for phototherapy, and discuss the significant influence and role of vacancy defects on phototherapy and multimodal synergistic phototherapy. Therefore, we sincerely hope that this review can provide a profound understanding and inspiration for the design of advanced phototherapeutic nanomaterials, and significantly promote the development of the efficient therapies against tumor.

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Section: Vacancy Defective Nanomaterials-enhanced Phototherapy and Mu...mentioning

confidence: 99%

Vacancy defect-promoted nanomaterials for efficient phototherapy and phototherapy-based multimodal Synergistic Therapy

Xiong

Wang

et al. 2022

Front. Bioeng. Biotechnol.

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“…Secondly, hydrogel can realize controllable drug releasing [ 49 – 51 ]. Hydrogels can respond to various stimuli [ 52 ], for example, light [ 53 ], near infrared light (NIR) [ 54 – 56 ], temperature [ 57 , 58 ], pH [ 59 ], magnetic field [ 60 ], enzymes [ 61 ], ionic strength and electric field. The controlled release of drugs can be realized by virtue of the reversible expansion and contraction properties of hydrogels under specific stimulation conditions to fix the size of gel grids.…”

Section: Introductionmentioning

confidence: 99%

Enhanced postoperative cancer therapy by iron-based hydrogels

Zhang

et al. 2022

Biomater Res

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Surgical resection is a widely used method for the treatment of solid tumor cancers. However, the inhibition of tumor recurrence and metastasis are the main challenges of postoperative tumor therapy. Traditional intravenous or oral administration have poor chemotherapeutics bioavailability and undesirable systemic toxicity. Polymeric hydrogels with a three-dimensional network structure enable on-site delivery and controlled release of therapeutic drugs with reduced systemic toxicity and have been widely developed for postoperative adjuvant tumor therapy. Among them, because of the simple synthesis, good biocompatibility, biodegradability, injectability, and multifunctionality, iron-based hydrogels have received extensive attention. This review has summarized the general synthesis methods and construction principles of iron-based hydrogels, highlighted the latest progress of iron-based hydrogels in postoperative tumor therapy, including chemotherapy, photothermal therapy, photodynamic therapy, chemo-dynamic therapy, and magnetothermal-chemical combined therapy, etc. In addition, the challenges towards clinical application of iron-based hydrogels have also been discussed. This review is expected to show researchers broad perspectives of novel postoperative tumor therapy strategy and provide new ideas in the design and application of novel iron-based hydrogels to advance this sub field in cancer nanomedicine.

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“…intravenous injection) have a series of problems such as low efficiency of nanomaterials reaching tumor tissue, premature leakage of cargo, and profound toxicity caused by the long-term existence of the carrier in the body (24)(25)(26). Numerous studies have shown that hydrogel delivery system can prolong the sustained release time of materials, prolong the effect of materials, and improve the effect of tumor treatment (27). Adding nanomaterials into hydrogel solution by diffusion or grafting to hydrogel materials can directly hit the lesion site by implantation or injection to achieve the effect of local slow-release drugs (28,29).…”

Section: Introductionmentioning

confidence: 99%

Nanozyme Hydrogels for Self-Augmented Sonodynamic/Photothermal Combination Therapy

et al. 2022

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Sonosensitizer-mediated sonodynamic therapy (SDT) has emerged as a promising anti-tumor strategy. However, this strategy of continuous oxygen consumption further exacerbates the hypoxic tumor microenvironment, which limits its therapeutic efficacy. In this study, we designed a multifunctional hydrogel (PB+Ce6@Hy) that simultaneously co-delivers nanozyme prussian blue (PB) and sonosensitizer chlorin e6 (Ce6) for the realization of photothermal therapy (PTT) and enhanced SDT. When the hydrogel reaches the tumor tissue through local injection, the 808 nm laser can induce the hydrogel to warm up and soften, thereby triggering the release of PB and Ce6. PB can interact with endogenous H2O2in situ and generate sufficient oxygen to promote the Ce6-mediated SDT effect. Besides, due to the good encapsulation ability of the hydrogel, the nanomaterials can be released in a controlled manner by changing laser parameter, irradiation time, etc. The experimental results show that the PB+Ce6@Hy system we developed can generate a large amount of reactive oxygen species (ROS), which can be combined with the photothermal effect to kill tumor cells, as a result, tumor proliferation has been adequately inhibited. This combined PTT/SDT dynamic strategy provides a new perspective for Ce6-induced cancer therapy, showing great potential for clinical application.

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NIR‐II Responsive Hydrogel as an Angiogenesis Inhibition Agent for Tumor Microenvironment Reprogramming

Abstract: The data that support the findings of this study are available from the corresponding author upon reasonable request.

Cited by 29 publications

References 37 publications

Vacancy defect-promoted nanomaterials for efficient phototherapy and phototherapy-based multimodal Synergistic Therapy

Vacancy defect-promoted nanomaterials for efficient phototherapy and phototherapy-based multimodal Synergistic Therapy

Enhanced postoperative cancer therapy by iron-based hydrogels

Nanozyme Hydrogels for Self-Augmented Sonodynamic/Photothermal Combination Therapy

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