NIR-Laser-Controlled Drug Release from DOX/IR-780-Loaded Temperature-Sensitive-Liposomes for Chemo-Photothermal Synergistic Tumor Therapy

Yan, Fei; Duan, Wanlu; Li, Ye-kuo; Wu, Hao; Zhou, Yi; Pan, Min; Li, Hongmei; Liu, Xin; Zheng, Hairong

doi:10.7150/thno.14937

Cited by 138 publications

(110 citation statements)

References 51 publications

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“…The appearance of voids in tumor section was associated with the loss of dead tumor cells. 34 Saline and DEX-SS-IND displayed intact nuclei morphology, suggesting negligible apoptosis or necrosis. Compared with free DOX and DEX-IND/ DOX micelles, more voids in tumor section was observed in tumor-bearing mice treated with DEX-SS-IND/DOX micelles, suggesting DEX-SS-IND/DOX micelles could effectively suppress MDR and exert antitumor efficacy.…”

Section: Histological Analysismentioning

confidence: 99%

Doxorubicin-loaded redox-responsive micelles based on dextran and indomethacin for resistant breast cancer

Zhou¹,

Wang²,

Ying³

et al. 2017

IJN

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Multidrug resistance (MDR) against chemotherapeutic agents has become one of the major obstacles to successful cancer therapy and MDR-associated proteins (MRPs)-mediated drug efflux is the key factor for MDR. In this study, a redox-responsive polymer based on dextran (DEX) and indomethacin (IND), which could reduce MRPs-mediated efflux of chemotherapeutics, was synthesized, and the obtained polymer could spontaneously form stable micelles with well-defined core-shell structure and a uniform size distribution with an average diameter of 50 nm and effectively encapsulate doxorubicin (DOX); the micelles contain a disulfide bridge (cystamine, SS) between IND and DEX (DEX-SS-IND). In vitro drug release results indicated that DEX-SS-IND/DOX micelles could maintain good stability in a stimulated normal physiological environment and promptly depolymerized and released DOX in a reducing environment. After incubating DEX-SS-IND/DOX micelles with drug-resistant tumor (MCF-7/ADR) cells, the intracellular accumulation and retention of DOX were significantly increased under the synergistic effects of redox-responsive delivery and the inhibitory effect of IND on MRPs. In vitro cytotoxicity showed that DEX-SS-IND/DOX micelles exhibited higher cytotoxicity against MCF-7/ADR cells. Moreover, DEX-SS-IND/DOX micelles showed significantly enhanced inhibition of tumor in BALB/c nude mice bearing MCF-7/ADR tumors and reduced systemic toxicity. Overall, the cumulative evidence indicates that DEX-SS-IND/DOX micelles hold significant promise for overcoming MDR for cancer therapy.

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Section: Histological Analysismentioning

confidence: 99%

Doxorubicin-loaded redox-responsive micelles based on dextran and indomethacin for resistant breast cancer

Zhou¹,

Wang²,

Ying³

et al. 2017

IJN

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“…It has been reported that IR780 could effectively produce heat and generate singlet oxygen after irradiation with 808 nm laser, suggesting that IR780 can be an ideal agent for PTT and PDT. 17,18 In our proposed drug delivery system, HSA is a biocompatible and biodegradable carrier platform to deliver DTX, an effective antitumor drug, and IR780, a PTT/PDT agent. Furthermore, IR780 could also serve as a fluorescent imaging probe.…”

mentioning

confidence: 99%

Self-assembled albumin nanoparticles for combination therapy in prostate cancer

Lian

et al. 2017

IJN

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Resistance to regular treatment strategies is a big challenge in the treatment of castration-resistant prostate cancer. Combination of photothermal and photodynamic therapy (PTT/PDT) with chemotherapy offers unique advantages over monotherapy alone. However, free drugs, such as photosensitizers and chemotherapeutic agents, lack tumor-targeted accumulation and can be easily eliminated from the body. Moreover, most of the PTT drugs are hydrophobic and their organic solvents have in vivo toxicity, thereby limiting their potential in clinical translation. Herein, simple multifunctional nanoparticles (NPs) using IR780 (a near-infrared dye) and docetaxel (DTX)-loaded nanoplatform based on human serum albumin (HSA) (HSA@IR780@DTX) was developed for targeted imaging and for PTT/PDT with chemotherapy for the treatment of castration-resistant prostate cancer treatment. In this platform, HSA is a biocompatible nanocarrier that binds to both DTX and IR780. DTX and IR780, as hydrophobic drug, can induce the self-assembly of HSA proteins. Transmission electron microscopic imaging showed that NPs formed by self-assembly are spherical with a smooth surface with a hydrodynamic diameter of 146.5±10.8 nm. The cytotoxicity of HSA@IR780@DTX NPs with or without laser irradiation in prostate cancer cells (22RV1) was determined via CCK-8 assay. The antitumor effect of HSA@IR780@DTX plus laser irradiation was better than either HSA@IR780@DTX without laser exposure or single PTT heating induced by HSA@IR780 NPs under near-infrared laser, suggesting a significant combined effect in comparison to monotherapy. Near-infrared fluorescence imaging showed that HSA@IR780@DTX NPs could preferentially accumulate in tumors. In vivo therapeutic efficacy experiment showed that xenografted prostate tumors on mice treated with HSA@IR780@DTX plus near-infrared laser irradiation were completely inhibited, whereas tumors on mice treated with chemotherapy alone (HSA@DTX and HSA@IR780@DTX without laser) or PTT/PDT alone (HSA@IR780 with laser) showed moderate growth inhibition. Overall, HSA@IR780@DTX NPs showed notable targeting and theranostic potential for the treatment of castration-resistant prostate cancer.

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“…To exemplify, Caixia Yue et al, (2013) reported that the IR-780 dye loaded tumor targeting theranostic nanoparticles for NIR imaging and PTT in which loading therapeutics agents would be difficult as the carrier is made of hydrophilic heparin. [8] A similar work was done by Fei Yan et al, (2016) where they used liposomes for co-loading IR-780 and DOX for treating breast cancers. However, the major limitation of their study is the intratumoral injection, which could reduce the efficacy when translating it in human use.…”

Section: Resultsmentioning

confidence: 94%

“…[8] A similar work was done by Fei Yan et al, (2016) where they used liposomes for co-loading IR-780 and DOX for treating breast cancers. [15] Since the chemo-agent DOX must be precisely released inside the tumor cells only on NIR irradiation, NEMSn would be a better option. [15] Since the chemo-agent DOX must be precisely released inside the tumor cells only on NIR irradiation, NEMSn would be a better option.…”

Section: Resultsmentioning

confidence: 94%

Olive Oil‐Based Ultrafine Theranostic Photo Nanoemulsions: A Versatile Tumor Maneuvering Nanoplatform for Precise Controlled Drug Release in Tumor and Complete Tumor Eradication Mediated by Photo‐Chemotherapy

Rejinold

Cherukula

et al. 2019

Advanced Therapeutics

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Photothermal therapy (PTT) is an efficient approach to treat tumors. However, heterogeneous distribution of heat by PTT in the tumor region often results in tumor regrowth and metastasis. Integrating PTT with chemotherapy in a precisely controlled tumor maneuvering and drug-releasing nanoconstruct will be an ideal strategy for higher therapeutic index. Herein, nanoemulsions (NEMSn) based on a highly biocompatible extra virgin olive oil are developed to encapsulate IR-780 for PTT and near infrared fluorescence imaging as well as doxorubicin (DOX) for chemotherapy. NEMSn are further stabilized with Tween-20 and hyaluronic acid to form an ultrafine theranostic photo nanoemulsions (UTPNEMSn) for combinatorial photo-chemotherapy. Once injected into the system, UTPNEMS homes to the tumor region owing to passive targeting. Tumor accumulated UTPNEMSn readily destabilizes upon laser irradiation to release the DOX, thereby synergizing the therapeutic effects of DOX and PTT. In vivo studies demonstrate a complete tumor eradication without tumor recurrence or systemic toxicity, owing to their biocompatible formulation. By virtue of the olive oil based NEMSNs and precise controlled drug releasing properties collaborating with the synergistic therapeutic modalities, UTPNEMSn are able to provide a promising method for controlled drug delivery systems.

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NIR-Laser-Controlled Drug Release from DOX/IR-780-Loaded Temperature-Sensitive-Liposomes for Chemo-Photothermal Synergistic Tumor Therapy

Cited by 138 publications

References 51 publications

Doxorubicin-loaded redox-responsive micelles based on dextran and indomethacin for resistant breast cancer

Doxorubicin-loaded redox-responsive micelles based on dextran and indomethacin for resistant breast cancer

Self-assembled albumin nanoparticles for combination therapy in prostate cancer

Olive Oil‐Based Ultrafine Theranostic Photo Nanoemulsions: A Versatile Tumor Maneuvering Nanoplatform for Precise Controlled Drug Release in Tumor and Complete Tumor Eradication Mediated by Photo‐Chemotherapy

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