Nisin/polyanion layer-by-layer films exhibiting different mechanisms in antimicrobial efficacy

Fael, Hanan; Demirel, A. Levent

doi:10.1039/c9ra10135g

Cited by 19 publications

(11 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The presence of amorphous drug in zein fibers, and the high encapsulation efficiency, prolonged stability of the drug within the fibers, and its near-complete release from the fibers, demonstrates that the fabricated zein fibers may potentially be used as a fast release antimicrobial layer, that could be introduced into wound dressings to reach initial MIC. The fast release of antimicrobial agents is beneficial in heavily contaminated wounds, for eradicating existing bacteria and reducing the formation of a biofilm [67][68][69]. Successful optimization of the physico-mechanical properties of zein fibers, such as higher hydrophilicity, elasticity and better water stability, as compared to pure zein fibers, brings them closer to realizing the properties of an ideal wound dressing.…”

Section: Discussionmentioning

confidence: 99%

Highly Elastic and Water Stable Zein Microfibers as a Potential Drug Delivery System for Wound Healing

et al. 2020

View full text Add to dashboard Cite

The development of biomaterials for wound healing applications requires providing a number of properties, such as antimicrobial action, facilitation of cell proliferation, biocompatibility and biodegradability. The aim of the present study was to investigate morphological and mechanical properties of zein-based microfibers, ultimately aimed at creating an environment suitable for wound healing. This was achieved through co-axial electrospinning of core–shell microfibers, with zein protein in the core and polyethylene oxide (PEO) in the shell. Small amounts of PEO or stearic acid were additionally incorporated into the fiber core to modify the morphology and mechanical properties of zein fibers. The presence of PEO in the core was found to be essential for the formation of tubular fibers, whereas PEO in the shell enhanced the stability of the microfibers in water and ensured high elasticity of the microfiber mats. Tetracycline hydrochloride was present in an amorphous form within the fibers, and displayed a burst release as a result of pore-formation in the fibers. The developed systems exhibited antimicrobial activity against Staphylococcus aureus and Escherichia coli, and showed no cytotoxic effect on fibroblasts. Biocompatibility, antimicrobial activity and favorable morphological and mechanical properties make the developed zein-based microfibers a potential biomaterial for wound healing purposes.

show abstract

Section: Discussionmentioning

confidence: 99%

Highly Elastic and Water Stable Zein Microfibers as a Potential Drug Delivery System for Wound Healing

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Many studies have demonstrated the capacity of nisin to inhibit the microbial growth of gram positive bacteria, including the highly pathogenic bacteria found in food, such as Staphylococcus aureus (Godoy- Santos et al, 2019), Staphylococcus epidermidis (Fael & Demirel, 2020), Clostridium botulinum (Gharsallaoui et al, 2016), and L. monocytogenes (Bastarrachea et al, 2010), among other pathogenic microorganisms (Nakazato et al, 2017).…”

Section: Effects Of Treatments On L Monocytogenes E Coli and S Typhimurium Cell Countsmentioning

confidence: 99%

Characterization and antimicrobial efficacy of active biocomposite containing polylactic acid, oregano essential oil and nisin for pork storage

et al. 2022

View full text Add to dashboard Cite

“…Nisin has also been formulated as films released from polymer/nisin multilayers; whereas nisin/polyacrylic acid (PAA) layers disintegrated in 24 h in water solution, nisin/dextran sulfate (DX) films were stable for 14 days without releasing nisin; both films hampered the spread of Staphylococcus epidermidis biofilms in disk diffusion tests; therapeutic utility proposed for nisin/PAA films was treating burns and wounds due to the quick nisin release, whereas nisin/DX coatings would impart steady sterilization of surfaces over long periods of time [ 71 ].…”

Section: Asa With Ampsmentioning

confidence: 99%

Antimicrobial Polymer−Based Assemblies: A Review

Carmona-Ribeiro

Araújo

2021

IJMS

View full text Add to dashboard Cite

An antimicrobial supramolecular assembly (ASA) is conspicuous in biomedical applications. Among the alternatives to overcome microbial resistance to antibiotics and drugs, ASAs, including antimicrobial peptides (AMPs) and polymers (APs), provide formulations with optimal antimicrobial activity and acceptable toxicity. AMPs and APs have been delivered by a variety of carriers such as nanoparticles, coatings, multilayers, hydrogels, liposomes, nanodisks, lyotropic lipid phases, nanostructured lipid carriers, etc. They have similar mechanisms of action involving adsorption to the cell wall, penetration across the cell membrane, and microbe lysis. APs, however, offer the advantage of cheap synthetic procedures, chemical stability, and improved adsorption (due to multipoint attachment to microbes), as compared to the expensive synthetic routes, poor yield, and subpar in vivo stability seen in AMPs. We review recent advances in polymer−based antimicrobial assemblies involving AMPs and APs.

show abstract

Nisin/polyanion layer-by-layer films exhibiting different mechanisms in antimicrobial efficacy

Abstract: Polyanion–nisin multilayer films exhibit antimicrobial activity by controlled release of nisin or as stable biofilm inhibiting coatings depending on polyanion.

Cited by 19 publications

References 52 publications

Highly Elastic and Water Stable Zein Microfibers as a Potential Drug Delivery System for Wound Healing

Highly Elastic and Water Stable Zein Microfibers as a Potential Drug Delivery System for Wound Healing

Characterization and antimicrobial efficacy of active biocomposite containing polylactic acid, oregano essential oil and nisin for pork storage

Antimicrobial Polymer−Based Assemblies: A Review

Contact Info

Product

Resources

About