Nisin Z attenuates lipopolysaccharide-induced mastitis by inhibiting the ERK1/2 and p38 mitogen-activated protein kinase signaling pathways

Huang, Fuqing; Teng, Kunling; Liu, Yayong; Wang, Tianwei; Xia, Tianqi; Yun, Fangfei; Zhong, Jin

doi:10.3168/jds.2021-21356

Cited by 15 publications

(9 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nisin is the most widely applied bacteriocin in the food industry. Huang et al [ 34 ] found that Nisin Z isolated from Lactococcus lactis inhibited the release of IL-6, IL-1β and TNF-α and increased IL-10 in LPS-induced MCF10A cells. Moreover, Nisin A from L. lactis was reported to diminish TNF-α level induced by LPS in peripheral blood mononuclear cells [ 35 ].…”

Section: Resultsmentioning

confidence: 99%

Screening and Probiotic Potential Evaluation of Bacteriocin-Producing Lactiplantibacillus plantarum In Vitro

Liu

et al. 2022

Foods

View full text Add to dashboard Cite

Probiotics are gaining attention due to their functions of regulating the intestinal barrier and promoting human health. The production of bacteriocins is one of the important factors for probiotics to exert beneficial properties. This study aimed to screen bacteriocin-producing Lactiplantibacillus plantarum and evaluate the probiotic potential in vitro. It was found that L. plantarum Q7, L. plantarum F3-2 and L. plantarum YRL45 could produce bacteriocins and inhibit common intestinal pathogens. These three strains had probiotic potential with tolerance to the gastrointestinal environmental and colonization in the gut, and exhibited various degrees of anti-inflammatory activity and tight junction function in the intestinal barrier. Particularly, L. plantarum YRL45 could significantly (p < 0.05) reduce the increase in nitric oxide (NO), prostaglandin E2 (PGE2), necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) induced by lipopolysaccharide (LPS), thereby easing inflammatory response. L. plantarum F3-2 could remarkably (p < 0.05) up-regulate the expression levels of ZO-1, Occludin and Claudin-1 in intestinal epithelial injured cells, which was conducive to protecting the intestinal barrier. These findings provided fundamental information about the probiotic properties of bacteriocin-producing L. plantarum, which suggested that L. plantarum Q7, L. plantarum F3-2 and L. plantarum YRL45 had the potential to be used as novel probiotic strains.

show abstract

Section: Resultsmentioning

confidence: 99%

Screening and Probiotic Potential Evaluation of Bacteriocin-Producing Lactiplantibacillus plantarum In Vitro

Liu

et al. 2022

Foods

View full text Add to dashboard Cite

show abstract

“…The ERK1/2 cascade is a central signaling pathway that regulates a wide variety of stimulated cellular processes, such as proliferation, differentiation, survival, apoptosis, and stress response [ 55 ]. Several studies have showed that the modulation of ERK and MAPK signaling pathway can lead to anti-inflammatory role in mastitis due to the decreased release of pro-inflammatory cytokines such as tumor necrosis factor-α, IL-1β, and IL-6 [ 56 – 59 ].…”

Section: Discussionmentioning

confidence: 99%

Metataxonomic analysis and host proteome response in dairy cows with high and low somatic cell count: a quarter level investigation

Winther

Duarte

Porcellato

2023

Vet Res

View full text Add to dashboard Cite

Host response to invasive microbes in the bovine udder has an important role on the animal health and is essential to the dairy industry to ensure production of high-quality milk and reduce the mastitis incidence. To better understand the biology behind these host-microbiome interactions, we investigated the somatic cell proteomes at quarter level for four cows (collected before and after milking) using a shotgun proteomics approach. Simultaneously, we identified the quarter microbiota by amplicon sequencing to detect presence of mastitis pathogens or other commensal taxa. In total, 32 quarter milk samples were analyzed divided in two groups depending on the somatic cell count (SCC). The high SCC group (>100,000 cell/mL) included 10 samples and significant different proteome profiles were detected. Differential abundance analysis uncovers a specific expression pattern in high SCC samples revealing pathways involved in immune responses such as inflammation, activation of the complement system, migration of immune cells, and tight junctions. Interestingly, different proteome profiles were also identified in quarter samples containing one of the two mastitis pathogens, Staphylococcus aureus and Streptococcus uberis, indicating a different response of the host depending on the pathogen. Weighted correlation network analysis identified three modules of co-expressed proteins which were correlated with the SCC in the quarters. These modules contained proteins assigned to different aspects of the immune response, but also amino sugar and nucleotide sugar metabolism, and biosynthesis of amino acids. The results of this study provide deeper insights on how the proteome expression changes at quarter level in naturally infected cows and pinpoint potential interactions and important biological functions during host-microbe interaction.

show abstract

“…Nisins are classified as GRAS and are a food additive regulated in several countries [ 72 ]. In recent studies, nisin was tested as a possible chemotherapeutic for the treatment of bovine mastitis, in which Staphylococcus is one of the most important etiological agents, and which often results in prolonged, recurrent, and persistent infections [ 73 , 74 ]. Although not essentially a food-derived AMP, nisin production is often associated with whey valorization processes [ 75 ].…”

Section: The Antimicrobial Activity Of Food-sourced Peptidesmentioning

confidence: 99%

Bioactive Antimicrobial Peptides from Food Proteins: Perspectives and Challenges for Controlling Foodborne Pathogens

et al. 2023

View full text Add to dashboard Cite

Bioactive peptides (BAPs) derived from food proteins have been extensively studied for their health benefits, majorly exploring their potential use as nutraceuticals and functional food components. These peptides possess a range of beneficial properties, including antihypertensive, antioxidant, immunomodulatory, and antibacterial activities, and are naturally present within dietary protein sequences. To release food-grade antimicrobial peptides (AMPs), enzymatic protein hydrolysis or microbial fermentation, such as with lactic acid bacteria (LAB), can be employed. The activity of AMPs is influenced by various structural characteristics, including the amino acid composition, three-dimensional conformation, liquid charge, putative domains, and resulting hydrophobicity. This review discusses the synthesis of BAPs and AMPs, their potential for controlling foodborne pathogens, their mechanisms of action, and the challenges and prospects faced by the food industry. BAPs can regulate gut microbiota by promoting the growth of beneficial bacteria or by directly inhibiting pathogenic microorganisms. LAB-promoted hydrolysis of dietary proteins occurs naturally in both the matrix and the gastrointestinal tract. However, several obstacles must be overcome before BAPs can replace antimicrobials in food production. These include the high manufacturing costs of current technologies, limited in vivo and matrix data, and the difficulties associated with standardization and commercial-scale production.

show abstract

Nisin Z attenuates lipopolysaccharide-induced mastitis by inhibiting the ERK1/2 and p38 mitogen-activated protein kinase signaling pathways

Cited by 15 publications

References 47 publications

Screening and Probiotic Potential Evaluation of Bacteriocin-Producing Lactiplantibacillus plantarum In Vitro

Screening and Probiotic Potential Evaluation of Bacteriocin-Producing Lactiplantibacillus plantarum In Vitro

Metataxonomic analysis and host proteome response in dairy cows with high and low somatic cell count: a quarter level investigation

Bioactive Antimicrobial Peptides from Food Proteins: Perspectives and Challenges for Controlling Foodborne Pathogens

Contact Info

Product

Resources

About