Nissl Substance and Ribosomal Aggregates

Nievel, John G.; Cumings, J. N.

doi:10.1038/2141123a0

Cited by 13 publications

(3 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These smaller neurons should be considered to correspond with our intercalated neurons, and the negative neurons proven by the histofluorescence method (Swaab et al, 1975), and the multipolar neurons shown by the Golgi-Cox method in the rabbit and rat SO (Felton and Cashner, 1979;Dyball and Kemplay, 1982). Nissl substance is very active in protein synthesis (Nievel and Cumings, 1967). Therefore, the presence of abundant Nissl substance in intercalated neurons suggests strongly that they have a high potential for synthesizing protein.…”

Section: Discussionmentioning

confidence: 62%

Histochemical studies on the distribution of thiamine pyrophosphatase and enzymes related to carbohydrate metabolism in the intercalated neurons of the rat supraoptic nucleus

Iijima

Saitô

1983

Am. J. Anat.

View full text Add to dashboard Cite

Histochemical studies have been conducted by applying hexokinase (HK), aldolase (AD), glyceraldehyde-3-phosphate dehydrogenase (G3), succinate dehydrogenase (SDH), glucose-6-phosphate dehydrogenase (G6PD), and thiamine pyrophosphatase (TPPase) methods, as well as Nissl staining and Gomori's chrome-alum-hematoxylin-phloxine (CHP) methods to intercalated neurons of the supraoptic nucleus (SO) on Wistar strain rats. Intercalated neurons reacted weakly to the AD, G3, G6PD, and SDH tests, indicating that they belong to the category of ordinary neurons with low carbohydrate metabolism. Many fibrous astrocytes showing strong HK reactions surround neurosecretory neurons. However, they do not surround intercalated neurons with mild HK activity. These results indicate that the latter receive a poor supply of energy from glucose in the circulating blood in contrast to the former. Intercalated neurons are very rich in Nissl substance but lack CHP-positive material. They may have a high potential for synthesizing protein. The principal morphological features of the TPPase-positive Golgi material are peculiar and heterogeneous shape and poor development. These findings together with mild G6PD activity suggest that intercalated neurons are very likely to have poor synthesizing activity.

show abstract

Section: Discussionmentioning

confidence: 62%

Histochemical studies on the distribution of thiamine pyrophosphatase and enzymes related to carbohydrate metabolism in the intercalated neurons of the rat supraoptic nucleus

Iijima

Saitô

1983

Am. J. Anat.

View full text Add to dashboard Cite

show abstract

“…At the center, the ER network is more complex with ‘ribbon’ and ‘thread’ like cisternae. Distribution of the Nissl bodies has been found to vary in its size, quantity, form, and degree of orientation of the ER in different types of neurons [ 15 , 151 ]. For example, the Nissl bodies in neurons of the sympathetic ganglion are usually smaller than those in the dorsal root ganglion cells and the motor neurons [ 15 ].…”

Section: Er Morphology In Neurons With a Focus On Mature Neuronsmentioning

confidence: 99%

Morphological Heterogeneity of the Endoplasmic Reticulum within Neurons and Its Implications in Neurodegeneration

Sree

Parkkinen

Their

et al. 2021

Cells

View full text Add to dashboard Cite

The endoplasmic reticulum (ER) is a multipurpose organelle comprising dynamic structural subdomains, such as ER sheets and tubules, serving to maintain protein, calcium, and lipid homeostasis. In neurons, the single ER is compartmentalized with a careful segregation of the structural subdomains in somatic and neurite (axodendritic) regions. The distribution and arrangement of these ER subdomains varies between different neuronal types. Mutations in ER membrane shaping proteins and morphological changes in the ER are associated with various neurodegenerative diseases implying significance of ER morphology in maintaining neuronal integrity. Specific neurons, such as the highly arborized dopaminergic neurons, are prone to stress and neurodegeneration. Differences in morphology and functionality of ER between the neurons may account for their varied sensitivity to stress and neurodegenerative changes. In this review, we explore the neuronal ER and discuss its distinct morphological attributes and specific functions. We hypothesize that morphological heterogeneity of the ER in neurons is an important factor that accounts for their selective susceptibility to neurodegeneration.

show abstract

“…Nissl granules are not directly involved in therapeutic manipulation as they are an intrinsic component of the neuron and manipulating them directly is not a common therapeutic approach. As medical professionals, our pursuit of innovative approaches to enhance tissue repair and regeneration compels us to delve into the nuanced world of Nissl granules and their promising implications for regenerative medicine [1][2][3][4]. Nissl granules, residing predominantly in the cell bodies of neurons, have long been recognized as vital hubs for protein synthesis.…”

Section: Introductionmentioning

confidence: 99%

Nissl Granules, Axonal Regeneration, and Regenerative Therapeutics: A Comprehensive Review

Bhati,

Thakre,

Anjankar

2023

Cureus

View full text Add to dashboard Cite

Nissl granules, traditionally recognized for their pivotal role in protein synthesis within neuronal cell bodies, are emerging as intriguing components with far-reaching implications in the realm of regenerative therapeutics. This abstract encapsulates the essence of a comprehensive review, exploring the nexus between Nissl granules, axonal regeneration, and their transformative applications in regenerative medicine. The molecular intricacies of Nissl granules form the foundation of this exploration, unraveling their dynamic role in orchestrating cellular responses, particularly in the context of axonal regeneration. As we delve into the interplay between Nissl granules and regenerative processes, this review highlights the diverse mechanisms through which these granules contribute to neuronal repair and recovery. Beyond their conventional association with neurobiology, recent advancements underscore the translational potential of Nissl granules as therapeutic agents. Insights into their involvement in enhancing axonal regeneration prompt a reconsideration of these granules as key players in the broader field of regenerative medicine. The abstract encapsulates evidence suggesting that modulating Nissl granule-related pathways holds promise for augmenting tissue regeneration, extending their applicability beyond the confines of the nervous system. This review aims to serve as a valuable resource for medical professionals, researchers, and clinicians seeking to comprehend the multifaceted role of Nissl granules in regenerative therapeutics. By illuminating the intricate connections between Nissl granules, axonal regeneration, and therapeutic applications, this work aspires to catalyze further research and innovation, ultimately contributing to the evolution of regenerative strategies that harness the innate reparative capacities within cellular constituents.

show abstract

Nissl Substance and Ribosomal Aggregates

Cited by 13 publications

References 5 publications

Histochemical studies on the distribution of thiamine pyrophosphatase and enzymes related to carbohydrate metabolism in the intercalated neurons of the rat supraoptic nucleus

Histochemical studies on the distribution of thiamine pyrophosphatase and enzymes related to carbohydrate metabolism in the intercalated neurons of the rat supraoptic nucleus

Morphological Heterogeneity of the Endoplasmic Reticulum within Neurons and Its Implications in Neurodegeneration

Nissl Granules, Axonal Regeneration, and Regenerative Therapeutics: A Comprehensive Review

Contact Info

Product

Resources

About