Nitensidine B affects proteins of the glycolytic pathway and induces apoptosis in cervical carcinoma cells immortalized by HPV16

Souza, Felipe de Oliveira; Sorbo, Juliana Maria; Regasini, Luís Octávio; Bolzani, Vanderlan da Silva; Rosa, José César; Czernys, Érica da Silva; Valente, Valéria; Moreira, Thaís Fernanda; Navegante, Geovana; Fernandes, Barbara Colatto; Soares, Christiane Pienna

doi:10.1016/j.phymed.2018.05.016

Cited by 13 publications

(4 citation statements)

References 35 publications

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“…Under normal circumstances, apoptosis acts as the fundamental role for the physiological balance in multicellular organisms [3]. Recently, emerging reports demonstrated that anticancer effects of natural products and their derivatives were involved in the pro-apoptotic action, which is considered as a promising approach for the treatment of malignancy [32,33]. Previous studies have reported that Rh 2 could induce human hepatoma SK-HEP-1 cells apoptosis via Bax/Bak triggered cytochrome c release and caspase-9/caspase-8 activation to execute cancer cell death [34].…”

Section: Resultsmentioning

confidence: 99%

Immunomodulatory Effects of (24R)-Pseudo-Ginsenoside HQ and (24S)-Pseudo-Ginsenoside HQ on Cyclophosphamide-Induced Immunosuppression and Their Anti-Tumor Effects Study

Zeng

Chen

et al. 2019

IJMS

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(24R)-pseudo-ginsenoside HQ (R-PHQ) and (24S)-pseudo-ginsenoside HQ (S-PHQ) are the main metabolites of (20S)-ginsenoside Rh2 (Rh2) in vivo. In this study, we found that Rh2, R-PHQ, and S-PHQ upregulated the innate and adaptive immune response in cyclophosphamide (CTX) induced-immunocompromised mice as evidenced by the number of leukocytes, cellular immunity, and phagocytosis of macrophages. Spleen T-lymphocyte subpopulations and the serum cytokines level were also balanced in these immunosuppressed mice. Furthermore, co-administration with R-PHQ or S-PHQ did not compromise the antitumor activity of CTX in the hepatoma H22-bearing mice. Treatment with R-PHQ and S-PHQ clearly induced the apoptosis of tumor cells, significantly increased the expression of Bax, and remarkably inhibited the expression of Bcl-2 and vascular endothelial growth factor (VEGF) in H22 tumor tissues. The anti-tumor activity of R-PHQ and S-PHQ could be related to the promotion of tumor apoptosis and inhibition of angiogenesis and may involve the caspase and VEGF signaling pathways. This study provides a theoretical basis for further study on R-PHQ and S-PHQ.

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Section: Resultsmentioning

confidence: 99%

Immunomodulatory Effects of (24R)-Pseudo-Ginsenoside HQ and (24S)-Pseudo-Ginsenoside HQ on Cyclophosphamide-Induced Immunosuppression and Their Anti-Tumor Effects Study

Zeng

Chen

et al. 2019

IJMS

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“…Moreover, cell cycle analysis suggested that compound 6 caused an increase in the subG1 phase and induced apoptosis in HeLa and SiHa cells. Induction of caspase-3 and -7 and inhibition of aldolase A, alpha-enolase, pyruvate kinase, and glyceraldehyde 3-p-dehydrogenase in both HPV16 and SiHa cells were observed after the exposure of nitensidine B isolated from leaves of Pterogyne nitens Tul [37]. Cells were treated at doses of 30 µM, 60 µM, and 120 µM for 6 h, 12 h, and 24 h. The result of study suggested that nitensidine B had efficacy on inducing apoptosis and inhibiting glycolysis.…”

Section: Compoundsmentioning

confidence: 98%

Therapeutic Potential of Natural Products in Treatment of Cervical Cancer: A Review

et al. 2021

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Cervical cancer is the fourth most common cancer among women worldwide. Though several natural products have been reported regarding their efficacies against cervical cancer, there has been no review article that categorized them according to their anti-cancer mechanisms. In this study, anti-cancerous natural products against cervical cancer were collected using Pubmed (including Medline) and google scholar, published within three years. Their mechanisms were categorized as induction of apoptosis, inhibition of angiogenesis, inhibition of metastasis, reduction of resistance, and regulation of miRNAs. A total of 64 natural products suppressed cervical cancer. Among them, Penicillium sclerotiorum extracts from Cassia fistula L., ethanol extracts from Bauhinia variegate candida, thymoquinone obtained from Nigella sativa, lipid-soluble extracts of Pinellia pedatisecta Schott., and 1′S-1′-acetoxychavicol extracted from Alpinia conchigera have been shown to have multi-effects against cervical cancer. In conclusion, natural products could be attractive candidates for novel anti-cancer drugs.

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“…A group of researchers surprisingly found 4w to be more effective when compared to its parent compounds and thus can be utilized for triggering anti-cancer potential in Hela cells [38]. A study also reported that purple root tubers as well as Ipomoea batatas leaves contain anthocyanins that can induce CFP or YFP activity in HeLa cells [39][40][41]. The therapy caused apoptosis, cell cycle arrest, and modification in cell architecture.…”

Section: Various Natural Compoundsmentioning

confidence: 99%

Therapeutic Effects of Natural Products Isolated from Different Microorganisms in Treating Cervical Cancer: A Review

Mukherjee

Lahiri

Nag

2022

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Cervical cancer is defined as a cancer arising in the cells of cervix that causes unusual vaginal bleeding, discharges, pain in the pelvic region, or pain during sexual activity. Cervical cancer is currently reported to be the fourth most prevalent malignancy among women globally. Surgery includes pelvic lymphadenectomy as well as radical hysterectomy, radiotherapy, as well as chemotherapy are the most common therapies for treating cervical cancer. Another approach includes targeted medication which affects the epidermal growth factor receptor (EGFR) and cyclooxygenase-2 (COX-2) for the curing cervical cancer. However, these therapies have the potential for risks and complications: surgery can result in bleeding and may cause organ damage surrounding the surgery, and clots may also start to form in the deep veins of the legs; radiotherapy can result in menopause, infertility, discomfort, or pain during intercourse; and chemotherapy can actually impact rapidly dividing cells along with cancer cells in the human body system. In this review, we will discuss about the use of several Randomised controlled trials (RCTs) for treating malnutrition in various oncology patients. In this review, we will discuss about the various therapeutic effects of natural products isolated from different microorganisms in treating cervical cancer.

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Nitensidine B affects proteins of the glycolytic pathway and induces apoptosis in cervical carcinoma cells immortalized by HPV16

Cited by 13 publications

References 35 publications

Immunomodulatory Effects of (24R)-Pseudo-Ginsenoside HQ and (24S)-Pseudo-Ginsenoside HQ on Cyclophosphamide-Induced Immunosuppression and Their Anti-Tumor Effects Study

Immunomodulatory Effects of (24R)-Pseudo-Ginsenoside HQ and (24S)-Pseudo-Ginsenoside HQ on Cyclophosphamide-Induced Immunosuppression and Their Anti-Tumor Effects Study

Therapeutic Potential of Natural Products in Treatment of Cervical Cancer: A Review

Therapeutic Effects of Natural Products Isolated from Different Microorganisms in Treating Cervical Cancer: A Review

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