Nitrate and Exercise Performance

Bailey, Stephen J.; Vanhatalo, Anni; Jones, Andrew M.

doi:10.1007/978-3-319-46189-2_20

Cited by 3 publications

(4 citation statements)

References 130 publications

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“…The optimal NO 3 − supplementation was between 5 and ~25 mmol·d −1 ingested 2–3.5 h before exercise. These data provide robust support of previous contentions from individual studies ( 19 , 53 ) and narrative reviews ( 1 , 9 , 117 ) considering optimal NO 3 − supplementation parameters. Thus, the general parameters for “successful” NO 3 − supplementation gleaned from our analysis are not novel; however, the current meta-analyses substantiate previous claims from leading experts regarding “best practices” for NO 3 − supplementation.…”

Section: Discussionsupporting

confidence: 83%

Ergogenic Effect of Nitrate Supplementation: A Systematic Review and Meta-analysis

Senefeld

Wiggins

Regimbal

et al. 2020

Medicine &Amp; Science in Sports &Amp; Exercise

104

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Section: Discussionsupporting

confidence: 83%

Ergogenic Effect of Nitrate Supplementation: A Systematic Review and Meta-analysis

Senefeld

Wiggins

Regimbal

et al. 2020

Medicine &Amp; Science in Sports &Amp; Exercise

104

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show abstract

“…Nitric oxide is a potent signalling molecule that plays a key role in vasodilation by relaxing the smooth muscle and subsequently improving blood circulation. This process is promoted in conditions of low partial pressure oxygen and pH that may exist in skeletal muscle during exercise, enabling nitric oxide to be produced where it is most required (28)(29)(30)(31).…”

Section: Nitrate Supplementationmentioning

confidence: 99%

“…Nitric oxide is a potent signalling molecule that plays a key role in vasodilation by relaxing the smooth muscle and subsequently improving blood circulation. This process is promoted in conditions of low partial pressure oxygen and acid-base imbalance or lactate acid accumulation that may exist in skeletal muscle during endurance racing that limits physical capacity (27), enabling NO to be produced where it is most required (28)(29)(30)(31). Interestingly, nitrate supplementation also reduces the oxygen cost of submaximal exercise and can, in some circumstances, enhance exercise tolerance and performance (28).…”

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confidence: 99%

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The effects of co-ingestion of highly branched cyclic dextrin and dietary nitrate on physiological responses and endurance capacity in recreational endurance runners

Chinapong

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This study aimed to investigate the effects of co-ingestion of HBCD and dietary nitrate on physiological responses and endurance capacity in recreational endurance runners compared with an isocaloric HBCD beverage, a maltodextrin-dietary nitrate beverage, and a maltodextrin beverage during high-intensity prolong running. Nine male marathon runners (age 35.00 ? 4.00 years) participated in a double-blind crossover design, where they were randomly assigned to receive either the co-ingesting 1.5 g HBCD?kg-1 BM and 500 mg dietary NO3- (~8.00 mmol NO3-) beverages (HBCD+NO3-), the ingesting 1.5 g HBCD?kg-1 BM (HBCD), the co-ingesting 1.5 g MD?kg-1 BM and 500 mg dietary NO3- (~8.00 mmol NO3-) beverages (MD+NO3-) or the ingesting 1.5 g MD?kg-1 BM beverage (MD) 60 min prior to the running economy test following by a 60-min constant load running at a speed equivalent to 70% of V?O2peak. Measurements of�substrate oxidation, muscle oxygenation, and oxygen cost were taken to assess running economy as well as serum glucose concentration, serum insulin concentration and blood lactate concentration, gastrointestinal symptoms, and rate of perceived exertion (RPE). The results showed no significant differences in the serum insulin concentration, serum glucose concentration, blood lactate concentration, oxygen cost, muscle oxygenation, among�the HBCD+NO3-, HBCD, MD+NO3-, and MD conditions. However, it was found that the ingesting HBCD it had increase fat oxidation rate and lower the RER compared to the HBCD+NO3-, the MD+NO3-, or MD. This indicate that the ingesting HBCD may modulate fat metabolism and affect the lower RER compared to the co-ingesting of HBCD+NO3- or other CHO sources.

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Dietary nitrate supplementation in cardiovascular health: an ergogenic aid or exercise therapeutic?

Woessner

McIlvenna

Zevallos

et al. 2018

American Journal of Physiology-Heart and Circulatory Physiology

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Oral consumption of inorganic nitrate, which is abundant in green leafy vegetables and roots, has been shown to increase circulating plasma nitrite concentration, which can be converted to nitric oxide in low oxygen conditions. The associated beneficial physiological effects include a reduction in blood pressure, modification of platelet aggregation, and increases in limb blood flow. There have been numerous studies of nitrate supplementation in healthy recreational and competitive athletes; however, the ergogenic benefits are currently unclear due to a variety of factors including small sample sizes, different dosing regimens, variable nitrate conversion rates, the heterogeneity of participants' initial fitness levels, and the types of exercise tests used. In clinical populations, the study results seem more promising, particularly in patients with cardiovascular diseases who typically present with disruptions in the ability to transport oxygen from the atmosphere to working tissues and reduced exercise tolerance. Many of these disease-related, physiological maladaptations, including endothelial dysfunction, increased reactive oxygen species, reduced tissue perfusion, and muscle mitochondrial dysfunction, have been previously identified as potential targets for nitric oxide restorative effects. This review is the first of its kind to outline the current evidence for inorganic nitrate supplementation as a therapeutic intervention to restore exercise tolerance and improve quality of life in patients with cardiovascular diseases. We summarize the factors that appear to limit or maximize its effectiveness and present a case for why it may be more effective in patients with cardiovascular disease than as ergogenic aid in healthy populations.

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Nitrate and Exercise Performance

Cited by 3 publications

References 130 publications

Ergogenic Effect of Nitrate Supplementation: A Systematic Review and Meta-analysis

Ergogenic Effect of Nitrate Supplementation: A Systematic Review and Meta-analysis

The effects of co-ingestion of highly branched cyclic dextrin and dietary nitrate on physiological responses and endurance capacity in recreational endurance runners

Dietary nitrate supplementation in cardiovascular health: an ergogenic aid or exercise therapeutic?

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