Nitration of Phenols Using Cu(NO₃)₂: Green Chemistry Laboratory Experiment

Abstract

An easy-to-complete, microwave-assisted, green chemistry, electrophilic nitration method for phenol using Cu(NO 3 ) 2 in acetic acid is discussed. With this experiment, students clearly understand the mechanism underlying the nitration reaction in one laboratory session.

Preparation of a steroid-oxazole-1,2′-[1,3]oxazete] derivative: biological and theoretical evaluation of its interaction with a kinase protein (CK2)

“…Some reagents have used to synthesis of nitro-derivatives such as Montmorrolinate KSF-Bi(NO 3 ) 3 [38], Bi(NO 3 ) 3 /5H 2 O [39], Cu(NO 3 ) 2 [40] and others. In this study, the nitration of compound 2 was carried out via HNO 3 /Acetic acid (Fig.…”

Greening the organic chemistry laboratory: a comparison of microwave-assisted and classical nucleophilic aromatic substitution reactions

“…The UN World Decade of an Education for Sustainable Development ended in 2014, and in that time, a curricular revolution has been realized where green chemistry content has become imbedded into undergraduate chemistry (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16). Future chemists will decide whether chemistry will develop with sustainability as part of the focus, but only if they have a strong foundation on sustainability issues and the meaning of making green chemistry development decisions.…”

Operative conversions of 3-carboxy-4-quinolones into 3-nitro-4-quinolones via ipso-nitration: potential antifilarial agents as inhibitors of Brugia malayi thymidylate kinase

“…The investigation started with the use of metal nitrates with acid combination and these methods led to the formation of products in good yield, but methodology required use of high stoichiometric ratio of acids (Table 1, entry 1-7). 22 The combination of sulphuric acid with other acids also led to the formation of products with same problem of waste products arises (Table 1, entry 8-12). 23 The others reported mild methods for nitration were also tried but the methodologies were limited to the use of non-green approaches (Table 1, entry 13-15).…”