Nitrergic neurons during early postnatal development of the prefrontal cortex in the rat: Histochemical study

Hvizdošová, Natália; Tomášová, Lenka; Boleková, Adriana; Kolesár, Dalibor; Kluchová, Darina

doi:10.1016/j.acthis.2014.01.001

Cited by 2 publications

(3 citation statements)

References 18 publications

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“…Neurotransmitter systems go through significant changes during adolescence (Andersen, Rutstein, Benzo, Hostetter, & Teicher, 1997;Tarazi, Tomasini, & Baldessarini, 1998;Teicher, Andersen, & Hostetter, 1995), including the nitrergic and glutamatergic systems (Guilarte & McGlothan, 1998;Haberny et al, 2002, for review). The latter undergoes robust pruning and neuronal death during neocortical development, and as for the nitrergic neurons, studies show they are mature around PND 21 (Haberny et al, 2002;Hvizdosova et al, 2014;Lizasoain et al, 1996). Protracted development of NMDA receptors and NO systems, as also here evidenced by lower NO production in adolescents, could have contributed to the low sensitivity to behavioral sensitization in adolescents.…”

Section: Discussionmentioning

confidence: 92%

“…The neuronal isoform of its synthetic enzyme, nitric oxide synthase (nNOS), is localized in several brain areas, including those involved in stress and addiction, such as hippocampus and prefrontal cortex (Blackshaw et al, 2003;Kubota & Kawaguchi, 1994). Nitrergic neurons and brain NOS activity reach maturity approximately after 21 postnatal days in rats (Hvizdosova, Tomasova, Bolekova, Kolesar, & Kluchova, 2014;Lizasoain, Weiner, Knowles, & Moncada, 1996). Exposure to stress increases nNOS activity in the hippocampus via glucocorticoid release (Harvey, Oosthuizen, Brand, Wegener, & Stein, 2004), and increases the number of nNOS positive neurons in the prefrontal cortex (Campos, Piorino, Ferreira, & Guimarães, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Involvement of neuronal nitric oxide synthase in cross-sensitization between chronic unpredictable stress and ethanol in adolescent and adult mice

Santos-Rocha

Rae

Teixeira

et al. 2018

Alcohol

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a b s t r a c tThe peculiar neurochemical profile of the adolescent brain renders it differently susceptible to several stimuli, including stress and/or drug exposure. Among several stress mediators, nitric oxide (NO) has a role in stress responses. We have demonstrated that adolescent mice are less sensitive to ethanolinduced sensitization than adult mice. The present study investigated whether chronic unpredictable stress (CUS) induces behavioral sensitization to ethanol in adolescent and adult Swiss mice, and investigated the influence of Ca 2þ -dependent nitric oxide synthase (NOS) activity in the phenomenon.Adolescent and adult mice were exposed to repeated 1.8 g/kg ethanol or CUS and challenged with saline or ethanol. A neuronal nitric oxide synthase (nNOS) inhibitor, 7-nitroindazole (7NI), was administered along with ethanol and CUS to test its effects on behavioral sensitization. Both adolescent and adult mice displayed cross-sensitization between CUS and ethanol in adult mice, with adolescents showing a lower degree of sensitization than adults. nNOS inhibition by 7NI reduced both ethanol sensitization and crosssensitization. All age differences in the Ca 2þ -dependent NOS activity in the hippocampus and prefrontal cortex were in the direction of greater activity in adults than in adolescents. Adolescents showed lower sensitivity to cross-sensitization between CUS and ethanol, and the nitric oxide (NO) system seems to have a pivotal role in ethanol-induced behavioral sensitization and cross-sensitization in both adolescent and adult mice.

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Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Involvement of neuronal nitric oxide synthase in cross-sensitization between chronic unpredictable stress and ethanol in adolescent and adult mice

Santos-Rocha

Rae

Teixeira

et al. 2018

Alcohol

View full text Add to dashboard Cite

show abstract

“…It is generally acknowledged that only around 98% of NADPH-d positive neurons in the cortex have nNOS (Kharazia et al 1994). A study used histochemical techniques of NADPHdiaphorase to evaluate the postnatal development of nitrergic neurons in the male rat pre-frontal cortex found that neurons begin to express NADPH-d at birth and differentiate during a relatively short period (Hvizdosova et al, 2014). While another study by Zhang and al. found that at the age of PND2, the striatum of control pups had a dense distribution of nNOS immunoreactive cells with no obvious sex difference (Zhang et al, 2018).…”

Section: Hypothalamusmentioning

confidence: 99%

Age and Gender-Dependent in Nitric Oxide Postnatal Change Activity in the Rat Brain

Ibouzine-Dine,

Berkiks,

Lamtai

et al. 2024

AAVS

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The postnatal period represents the critical window referring to specific intervals of time during which the brain's development exhibits increased sensitivity to specific types of learning and external influences. This period is usually associated with the development of age-related neurodevelopmental processes. Nitric oxide (NO) is an essential signaling molecules that play an important role in physiological processes including neuronal survival and differentiation, neurogenesis, synaptogenesis, pruning, and brain plasticity. In the present study, we aimed to determine the activity of NO during the early and late critical periods of structural and functional maturation of the central nervous system (CNS). In this study, we focused on the prefrontal cortex, hippocampus, striatum, and hypothalamus of male and female "Wistar" rat pups, as these areas have differential developing states. NO level was determined on postnatal days (PND)

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Nitrergic neurons during early postnatal development of the prefrontal cortex in the rat: Histochemical study

Cited by 2 publications

References 18 publications

Involvement of neuronal nitric oxide synthase in cross-sensitization between chronic unpredictable stress and ethanol in adolescent and adult mice

Involvement of neuronal nitric oxide synthase in cross-sensitization between chronic unpredictable stress and ethanol in adolescent and adult mice

Age and Gender-Dependent in Nitric Oxide Postnatal Change Activity in the Rat Brain

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