Nitric oxide and glutamate are contributors of anti-seizure activity of rubidium chloride: A comparison with lithium

Rahimi, Nastaran; Hassanipour, Mahsa; Yarmohammadi, Fatemeh; Faghir‐Ghanesefat, Hedyeh; Pourshadi, Nastaran; Bahramnejad, Erfan; Dehpour, Ahmad Reza

doi:10.1016/j.neulet.2019.134349

Cited by 19 publications

(14 citation statements)

References 39 publications

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“…Regarding plasma Rb concentrations, we found inverse correlations with fat, muscle and bone mass. Rb affects the activity of Na + and K + -ATPase due to the similar physicochemical property of Rb to potassium (K); this enzyme plays an important role in the homeostasis of Na + , K + and Ca 2+ in muscle cells and in the excitability of their membrane, contributing to the maintenance of vascular tone [55]. Stolk et al [56] suggested that Rb released larger amounts of neuronally stored norepinephrine to central adrenergic receptors, the known effects of which would cause an increase in heart rate, increased thermogenesis of brown adipose tissue, increased glucose uptake in the muscle as well as an increase in fatty tissue lipolysis that would favor the loss of fat mass in runners.…”

Section: Discussionmentioning

confidence: 99%

Association between Trace Elements and Body Composition Parameters in Endurance Runners

Barrientos

Alvés

Toro

et al. 2020

IJERPH

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The aim of this study was to determine the possible correlations between essential and toxic trace elements of plasma with several anthropometric and body composition parameters and performance in endurance runners. Sixty-five high-level middle and long-distance runners (21 ± 3 years; 1.77 ± 0.05 m; 64.97 ± 7.36 kg; VO2 max. 67.55 ± 4.11 mL/min/kg) participated in the present study. Abdominal, subscapular, iliac crest, triceps, front thigh and medial calf skinfold thicknesses and an incremental test until exhaustion were recorded. Body, fat, muscle and bone mass were estimated. Plasma trace elements were analyzed with inductively coupled plasma mass spectrometry (ICP-MS). Correlations and simple linear regression were used to assess the relationship between trace elements and several variables. Different skinfolds, fat mass, muscle mass and bone mass correlated positively and negatively with trace elements such as copper, manganese, selenium, vanadium, zinc, lithium, rubidium, strontium, arsenic, beryllium and lead. Lithium was related with performance. In conclusion, endurance training causes changes in the body concentrations of several trace elements that trigger modifications in body composition that may be interesting, if confirmed in the future, for the control of metabolic diseases such as obesity.

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Section: Discussionmentioning

confidence: 99%

Association between Trace Elements and Body Composition Parameters in Endurance Runners

Barrientos

Alvés

Toro

et al. 2020

IJERPH

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“…It has also been demonstrated that NO-mediated activation of the type 1 ryanodine receptor is crucial for seizure-induced neuronal death and that antagonists of this receptor have a neuroprotective effect, emerging as suitable candidates for ameliorating conditions following seizures (Mikami et al, 2016). Supporting this fact, it has been described that non-selectively blocking NOS can potentiate rubidium chloride anti-convulsive effects (Rahimi et al, 2019). Thus, given the onset of metabolic and mitochondrial alterations as a consequence of excitotoxicity in seizure activity and their relevance for neuronal damage, there has been a growing interest in the use of antioxidants and other neuroprotective drugs that prevent neuronal damage following seizures (Petkova et al, 2014;Mishra et al, 2015;Williams et al, 2015;Pauletti et al, 2019).…”

Section: Temporal Side Story: Temporal Lobe Epilepsymentioning

confidence: 95%

Going the Extra (Synaptic) Mile: Excitotoxicity as the Road Toward Neurodegenerative Diseases

Armada‐Moreira

Gomes

Pina

et al. 2020

Front. Cell. Neurosci.

202

128

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Excitotoxicity is a phenomenon that describes the toxic actions of excitatory neurotransmitters, primarily glutamate, where the exacerbated or prolonged activation of glutamate receptors starts a cascade of neurotoxicity that ultimately leads to the loss of neuronal function and cell death. In this process, the shift between normal physiological function and excitotoxicity is largely controlled by astrocytes since they can control the levels of glutamate on the synaptic cleft. This control is achieved through glutamate clearance from the synaptic cleft and its underlying recycling through the glutamate-glutamine cycle. The molecular mechanism that triggers excitotoxicity involves alterations in glutamate and calcium metabolism, dysfunction of glutamate transporters, and malfunction of glutamate receptors, particularly N-methyl-D-aspartic acid receptors (NMDAR). On the other hand, excitotoxicity can be regarded as a consequence of other cellular phenomena, such as mitochondrial dysfunction, physical neuronal damage, and oxidative stress. Regardless, it is known that the excessive activation of NMDAR results in the sustained influx of calcium into neurons and leads to several deleterious consequences, including mitochondrial dysfunction, reactive oxygen species (ROS) overproduction, impairment of calcium buffering, the release of pro-apoptotic factors, among others, that inevitably contribute to neuronal loss. A large body of evidence implicates NMDAR-mediated excitotoxicity as a central mechanism in the pathogenesis of many neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), and epilepsy. In this review article, we explore different causes and consequences of excitotoxicity, discuss the involvement of NMDAR-mediated

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“…It is a less studied alkali metal element and can e ciently transfer to the human body through the food chain (soil-plant-human) [1]. Since the rst report on its correlation with phenylketonuria and maple-syrup-urine disease [2], some studies have suggested its effects on tumor [3,4], depression [5][6][7] and cardiovascular system [8].…”

Section: Introductionmentioning

confidence: 99%

“…Some other studies have shown that Rb was a candidate anticancer drug [4,10]. Rb has been used as an anti-depressant drug for 40 years due to its low toxicity and high drug resistance [5,6,11]. While, up to now, it is still unclear what are the inhibition mechanisms of Rb on tumors and depression.…”

Section: Introductionmentioning

confidence: 99%

Rubidium chloride modulated the fecal microbiota community in mice

Chen

Zhuo

et al. 2020

Preprint

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Background: The microbiota plays an important role in host health. Although rubidium (Rb) has been used to study for depression and cancers, the interaction between microbial commensals and Rb is still unexplored. To gain the knowledge of the relationship between Rb and microbes, 51 mice receiving RbCl-based treatment and 13 untreated mice were evaluated of their characteristics and bacterial microbiome changes.Results: The 16S ribosomal RNA gene sequencing of feces showed RbCl generally maintained fecal microbial community diversity, while the shifts in fecal microbial composition were apparent after RbCl exposure for the first time. RbCl significantly enhanced the abundances of Rikenellaceae, Alistipes, Clostridium XlVa and sulfate-reducing bacteria including Deltaproteobacteria, Desulfovibrionales, Desulfovibrionaceae and Desulfovibrio. While, RbCl significantly inhibited the abundances of Tenericutes, Mollicutes, Anaeroplasmatales, Anaeroplasmataceae and Anaeroplasma lineages. Besides, with regarding to the composition of archaea, RbCl significantly enhanced the abundances of Crenarchaeota, Thermoprotei, Sulfolobales, Sulfolobaceae and Sulfolobus lineages. Conclusions: These results revealed that enrichments of Clostridium XlVa and Alistipes could affect the levels of serotonin, a critical signaling molecule of brain-gut-microbiota axis. Therefore, anticancer and anti-depressant effects of RbCl might be partly mediated by modifying brain-gut-microbiota axis.

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Nitric oxide and glutamate are contributors of anti-seizure activity of rubidium chloride: A comparison with lithium

Cited by 19 publications

References 39 publications

Association between Trace Elements and Body Composition Parameters in Endurance Runners

Association between Trace Elements and Body Composition Parameters in Endurance Runners

Going the Extra (Synaptic) Mile: Excitotoxicity as the Road Toward Neurodegenerative Diseases

Rubidium chloride modulated the fecal microbiota community in mice

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