Nitric Oxide and Synaptic Function

Schuman, E.

doi:10.1146/annurev.neuro.17.1.153

Cited by 135 publications

(154 citation statements)

References 61 publications

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“…It has been reported that NO participates in numerous functions in the CNS (Bon and Garthwaite 2003;Garthwaite and Boulton 1995;Schuman and Madison 1994;Lin et al 2010;Vincent 2010;Garthwaite 2008), and its role in the regulation of neuronal excitability has been demonstrated (Centonze et al 2001;Podda et al 2004;Xu et al 1998). Indeed, NO actions in the CNS are frequently documented as modulation of ion channels (Ahern et al 2002;Grassi et al 2004).…”

Section: Discussionmentioning

confidence: 99%

Inhibition of neuronal nitric oxide synthase prevents alterations in medial prefrontal cortex excitability induced by repeated cocaine administration

Nasif

Ramírez

et al. 2010

Psychopharmacology

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Section: Discussionmentioning

confidence: 99%

Inhibition of neuronal nitric oxide synthase prevents alterations in medial prefrontal cortex excitability induced by repeated cocaine administration

Nasif

Ramírez

et al. 2010

Psychopharmacology

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“…NO is synthesized from L-arginine by nitric oxide synthase (NOS) in response to the elevation of intracellular free calcium mostly due to the activation of N-methyl-D-aspartate (NMDA) receptors (for review, see Schuman and Madison 1994). It has been speculated that the area of inßuence for the single point emitter of NO may be up to 200 µm in diameter (Wood and Garthwaite 1994).…”

Section: Introductionmentioning

confidence: 99%

7-Nitroindazole, a nitric oxide synthase inhibitor, has anxiolytic-like properties in exploratory models of anxiety

et al. 1997

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The action of the novel nitric oxide synthase (NOS) inhibitor 7-nitroindazole (7-NI) was studied in different exploratory models of anxiety. In the rat plus-maze test, 7-NI potently increased time spent on open arms and percentage of open arm visits in a dose dependent manner with the minimal effective dose of 40 mg/kg. 7-NI caused an anxiolytic-like effect in the rat social interaction test. The minimal dose increasing social interaction time was 20 mg/kg. However, the drug also produced a clear sedative effect occurring even at smaller doses (10 mg/kg) in the open field test. 7-NI also showed an anxiolytic-like profile in the mouse light-dark compartment test and in the elevated plus-maze test, but the doses required were higher (80-120 mg/kg) than in rat models. Also, the sedative effect occurred at these doses in open field. We failed to demonstrate any effect of L-arginine either in the rat elevated plus-maze test or in the open field test at doses up to 600 mg/kg IP. These results indicate that there are no major interspecies differences between rats and mice in respect of action of 7-NI. The clear anxiolytic-like action of the nitric oxide synthase inhibitor in four different models shows that nitric oxide is involved in the process of anxiety and that NOS could be a new target in developing anxiolytic drugs.

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“…After being produced by target cells in response to presynaptic innervation, NO diffuses in aqueous environments and across lipid membranes, functioning as a rapid intracellular signal between post-and pre-synaptic neurons (Gally et al, 1990;Edelman and Gally, 1992). NO can modulate the stability of synaptic connections as demonstrated by its potent effects on synaptic physiology (Schuman and Madison, 1991;Bredt and Snyder, 1994;Schuman and Madison, 1994;Meffert et al, 1996;Pan et al, 1996), neuronal morphology (Renteria and Constantine-Paton, 1996;Hindley et al, 1997;Inglis et al, 1998;Wright et al, 1998), and neuronal survival (Farinelli et al, 1996;Estevez et al, 1998;Posada and Clarke, 1999). NOS expression often correlates with periods of axonal outgrowth and synapse formation (Roskams et al, 1994;Williams et al, 1994;Tenorio et al, 1995).…”

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confidence: 99%