Nitric oxide donors inhibit the acetylcholine-induced Cl? current in identifiedOnchidium neurons

Scalable Synthesis of Diazeniumdiolates: Application to the Preparation of MK-8150

“…In addition to NO being an active signal-inducing molecule in biological systems, it exhibits a wide variety of well-documented biological properties, such as antimicrobial, antitumor, and antiplatelet properties. Furthermore, it plays a role in the regulation of blood pressure, immune response, and neurotransmission . Diazeniumdiolate (DAZD)-based NO donors, which are typically stable as the respective salt or the derivatized O 2 -alkylated diazeniumdiolates, or with a polymeric coating, release 2 equiv of nitric oxide either under physiological conditions (pH 7.4 at 37 °C), or when metabolized by esterase via a known mechanism .…”

“…Furthermore, it plays a role in the regulation of blood pressure, 6 immune response, 7 and neurotransmission. 8 Diazeniumdiolate (DAZD)-based NO donors, which are typically stable as the respective salt or the derivatized O 2 -alkylated diazeniumdiolates, or with a polymeric coating, release 2 equiv of nitric oxide either under physiological conditions (pH 7.4 at 37 °C), or when metabolized by esterase via a known mechanism. 9 However, when NO is released from N,N-dialkylated DAZDs, their corresponding amine precursor (e.g., dimethylamine, diethylamine, pyrrolidine, piperidine) is generated and the released amines can back-react with an oxidative intermediate of nitric oxide to generate carcinogenic N-nitrosamines.…”

Inhibition of the glutamate‐induced K + current in identified onchidium neurons by nitric oxide donors

“…Nitric oxide (NO) is implicated as a central and peripheral neuronal messenger in a wide range of physiological processes, including vascular smooth muscle relaxation, neurotransmission, immunological reactions, and long-term modifications in the efficacy of central synapses (Moncada et al, 1991;Snyder, 1994;Sawada et al, 1997Sawada et al, , 1998Malen and Chapman, 1997;Lewin and Walters, 1999). NO is produced from L-arginine by the enzyme NO synthase (NOS), is highly membrane-permeant and may directly influence cell function by modulating second messenger systems and ion channel activity (Bredt and Snyder, 1992;Sawada et al, 1995).…”