Nitric oxide evaluation in upper and lower respiratory tracts in nasal polyposis

Abstract

The medical treatment of NP improves both airway reactivity and obstruction, whatever the presence of asthma, suggesting a functional link between upper and lower airway functions.

Nitric Oxide: A Promising Methodological Approach in Airway Diseases

“…Actually, an inverse correlation between nasal NO levels and the extent of sinus disease and the number of occluded paranasal sinuses has been reported [71,75,76]. The hypothesis of occluded sinus ostia was supported by the fact that after medical [75,77] and surgical [75] treatment of nasal polyps, nasal NO levels were significantly elevated. Especially in surgically treated patients, nasal NO levels were more elevated than in subjects who underwent pharmacological therapy [19].…”

“…Nasal polyposis is considered to be a chronic inflammatory condition in the nasal and paranasal sinus cavities, with symptoms such as nasal obstruction, anterior and posterior rhinorrhea, sneezing, loss of smell and facial pain [77]. It usually occurs in association with CRS, but the precise etiology of nasal polyps still remains unclear.…”

L-Arginine and Nitric Oxide in CNS Function and Neurodegenerative Diseases

“…Olfactory NO is thought to have three main functions: protection, mucociliary clearance, and airborne messengership. Interestingly, a study on the role of nasal NO in the inflammatory process found an improvement in nasal polyposis (Delclaux et al, 2008). Nasal NO has been proposed to be used as a diagnostic tool and also for treatment of various respiratory diseases.…”

Funktionen und Funktionsstörungen der respiratorischen Schleimhaut der Nase und der Nasennebenhöhlen

“…Zuverl ä ssige Normwerte k ö nnen aufgrund der gro ß en interindividuellen Schwankungen nicht angegeben werden [173] . Mittels der Messung des nasalen NO kann man nicht-invasiv Patienten mit einer chronischen Rhinosinusitis mit Polypenbildung von solchen ohne Polypen und Gesunden unterscheiden [174] und positive, medikament ö se Behandlungseff ekte best ä -tigen [175] . Gr ö ß te Unterschiede zu einer Normalpopulation lie ß en sich bei Patienten mit prim ä rer zili ä rer Dyskinesie und zystischer Fibrose nachweisen [176] , sodass f ü r diese Erkrankungen nasales NO als nicht-invasives Screeninginstrument diskutiert wird [177] .…”