Nitric Oxide Is Released Into Circulation With Whole-Body, Periodic Acceleration * *Dr. Sackner is Chief Executive Officer and Chairman Board of Directors, Non-Invasive Monitoring Systems, Inc., and owns approximately 37% of Non-Invasive Monitoring Systems, Inc. shares. He is also a member of the Board of Directors, Vivometrics, Inc., Ventura CA. Ms. Gummels owns approximately 0.2% of Non-Invasive Monitoring Systems shares. Dr. Adams is a member of the Scientific Advisory Board and owns approximately 0.1%

Sackner, Marvin A.; Gummels, Emerance; Adams, José A.

doi:10.1378/chest.127.1.30

Cited by 66 publications

(20 citation statements)

References 37 publications

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“…This leads to an increase in endothelial NO synthase (eNOS) and produces Nitric Oxide. Circulating NO produces vasodilation and increases skin blood flow [24,25]. Lohman, et al (2007) reports that skin blood flow might also increase due to friction forces applied by the mechanical vibration on the endothelial cells at the cellular level [8].…”

Section: Discussionmentioning

confidence: 99%

A comparison of whole body vibration and moist heat on lower extremity skin temperature and skin blood flow in healthy older individuals

et al. 2012

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SummaryBackgroundTissue healing is an intricate process that is regulated by circulation. Heat modalities have been shown to improve skin circulation. Recent research supports that passive vibration increases circulation without risk of burns. Study purpose is to compare and determine effects of short duration vibration, moist heat, and a combination of the two on skin blood flow (SBF) and skin temperature (ST) in elderly, non-diabetic individuals following short-term exposure.Material/MethodsTen subjects, 3 female and 7 male (55–73 years of age), received two interventions over three days: 1 – Active vibration, 2 – passive vibration, 3 – moist heat, 4 – moist heat combined with passive vibration (MHPV), 5 – a commercial massaging heating pad, and 6 – no intervention. SBF and ST were measured using a MOOR Laser Doppler before and after the intervention and the third measurement were taken 10 minutes following.ResultsMean SBF following a ten-minute intervention were significantly different in the combination of moist heat and passive vibration from the control, active vibration, and the commercial massaging heating pad. Compared to baseline measurements, this resulted in mean SBF elevation to 450% (at conclusion of 10 minutes of intervention) and 379% (10 minutes post). MHPV (p=0.02) showed significant changes in ST from the commercial massaging heating pad, passive vibration, and active vibration interventions.ConclusionsSBF in the lower legs showed greatest increase with MHPV. Interventions should be selected that are low risk while increasing lower extremity skin blood flow.

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Section: Discussionmentioning

confidence: 99%

A comparison of whole body vibration and moist heat on lower extremity skin temperature and skin blood flow in healthy older individuals

et al. 2012

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“…For this study, we have coined the term “active vibration” for this form of vibration intervention. One vascular study applied vertical vibration in the supine position (head-to-toe whole body acceleration) using a lower frequency (2 Hz) [18]. To date, there have been a small number of studies that have examined the effects of WBV on circulation with the subject resting and the target area receiving horizontal vibration.…”

Section: Introductionmentioning

confidence: 99%

A comparison of the effect of a variety of thermal and vibratory modalities on skin temperature and blood flow in healthy volunteers

et al. 2011

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SummaryBackgroundCirculation plays an essential role in tissue healing. Moist heat and warm water immersion have been shown to increase skin circulation; however, these heating modalities can cause burns. Recent research has shown that passive vibration can also increase circulation but without the risk of burns.Material/MethodsThe aim of this study is to compare the effects of short-duration vibration, moist heat, and a combination of the two on skin blood flow (SBF) and skin temperature (ST). Ten (10) subjects, 5 female and 5 male, aged 20–30 years of age, received two interventions a day for 3 consecutive days: Intervention 1 – Active vibration only (vibration exercise), Intervention 2 – passive vibration only, Intervention 3 – moist heat only, Intervention 4 – passive vibration combined with moist heat, Intervention 5 – a commercial massaging heating pad, and Intervention 6 – no intervention, resting in supine only (control). SBF and ST were measured using a laser Doppler imager during the 10 minute intervention and then throughout the nine minute recovery period.ResultsThe mean skin blood flow following a ten-minute intervention of the combination of passive vibration and moist heat was significantly different from the control, active vibration, and the commercial massaging heating pad. Skin temperature following the ten-minute interventions of moist heat alone and passive vibration alone were both significantly different from the commercial massaging heating pad and active vibration interventions.ConclusionsThe combination of passive vibration and moist heat produced the greatest increase in skin blood flow and the second highest increase in skin blood flow nine minutes post application.

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“…There remains a profound need for alternative therapeutic strategies that can improve muscle strength, ameliorate the dystrophic pathology, and enhance patient quality of life. Here we have examined the benefit of pGz, an enhancer of NO signaling, to treat the mdx mouse, a DMD experimental model [38]–[40]. pGz is a non-invasive, drug free approach, which is produced by applying sinusoidal motion to a supine body in a headward-footward direction using a motion platform [39], causing additional pulses to the circulation, increasing pulsatile shear stress to the vascular endothelium and the release of NO [41].…”

Section: Discussionmentioning

confidence: 99%

Whole Body Periodic Acceleration Is an Effective Therapy to Ameliorate Muscular Dystrophy in mdx Mice

et al. 2014

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Duchenne muscular dystrophy (DMD) is a genetic disorder caused by the absence of dystrophin in both skeletal and cardiac muscles. This leads to severe muscle degeneration, and dilated cardiomyopathy that produces patient death, which in most cases occurs before the end of the second decade. Several lines of evidence have shown that modulators of nitric oxide (NO) pathway can improve skeletal muscle and cardiac function in the mdx mouse, a mouse model for DMD. Whole body periodic acceleration (pGz) is produced by applying sinusoidal motion to supine humans and in standing conscious rodents in a headward-footward direction using a motion platform. It adds small pulses as a function of movement frequency to the circulation thereby increasing pulsatile shear stress to the vascular endothelium, which in turn increases production of NO. In this study, we examined the potential therapeutic properties of pGz for the treatment of skeletal muscle pathology observed in the mdx mouse. We found that pGz (480 cpm, 8 days, 1 hr per day) decreased intracellular Ca2+ and Na+ overload, diminished serum levels of creatine kinase (CK) and reduced intracellular accumulation of Evans Blue. Furthermore, pGz increased muscle force generation and expression of both utrophin and the carboxy-terminal PDZ ligand of nNOS (CAPON). Likewise, pGz (120 cpm, 12 h) applied in vitro to skeletal muscle myotubes reduced Ca2+ and Na+ overload, diminished abnormal sarcolemmal Ca2+ entry and increased phosphorylation of endothelial NOS. Overall, this study provides new insights into the potential therapeutic efficacy of pGz as a non-invasive and non-pharmacological approach for the treatment of DMD patients through activation of the NO pathway.

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Cited by 66 publications

References 37 publications

A comparison of whole body vibration and moist heat on lower extremity skin temperature and skin blood flow in healthy older individuals

A comparison of whole body vibration and moist heat on lower extremity skin temperature and skin blood flow in healthy older individuals

A comparison of the effect of a variety of thermal and vibratory modalities on skin temperature and blood flow in healthy volunteers

Whole Body Periodic Acceleration Is an Effective Therapy to Ameliorate Muscular Dystrophy in mdx Mice

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