Nitric-Oxide Mediated Effects of Transdermal Capsaicin Patches on the Ischemic Threshold in Patients with Stable Coronary Disease

Fragasso, Gabriele; Palloshi, Altin; Piatti, Pier Marco; Monti, Lucilla D.; Rossetti, E.; Setola, Emanuela; Montano, Chiara; Bassanelli, Giorgio; Calori, Giliola; Margonato, Alberto

doi:10.1097/01.fjc.0000137161.76616.85

Cited by 21 publications

(14 citation statements)

References 29 publications

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“…Cutaneous dilatation with transdermal use of capsaicin depends on age, gender and applied dose of capsaicin with young men being positive responders compared to older men; and women being non-responders (Munce and Kenney 2003;Ferrell et al, 2004) and no effect with repeated use (Roberts et al, 1992). Capsaicin significantly delays ST depression time during exercise test in male patients with stable coronary disease, indicating a possible role of capsaicin in arteriolar vasodilatation in men (Fragasso et al, 2004). Although there was no significant difference in the whole group, the resting heart rate was lower and SEVR (a measure of myocardial perfusion) was higher in men, after 4 weeks of regular chilli consumption.…”

Section: Glyceryl Trinitrate Salbutamolmentioning

confidence: 97%

The effect of 4-week chilli supplementation on metabolic and arterial function in humans

et al. 2006

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Objective: To investigate the effects of regular chilli ingestion on some indicators of metabolic and vascular function. Design: A randomized cross-over dietary intervention study. Setting: Launceston, Australia. Subjects: Healthy free-living individuals. Intervention: Thirty-six participants (22 women and 14 men), aged 46712 (mean7s.d.) years; BMI 26.474.8 kg/m 2 , consumed 30 g/day of a chilli blend (55% cayenne chilli) with their normal diet (chilli diet), and a bland diet (chilli-free) for 4 weeks each. Metabolic and vascular parameters, including plasma glucose, serum lipids and lipoproteins, insulin, basal metabolic rate, blood pressure, heart rate, augmentation index (AIx; an indicator of arterial stiffness), and subendocardialviability ratio (SEVR; a measure of myocardial perfusion), were measured at the end of each diet. In a sub-study, during week 3 of each dietary period, the vascular responses of 15 subjects to glyceryl-trinitrate (GTN) and salbutamol were also studied. Results: For the whole group, there were no significant differences between any of the measured parameters when compared at the end of the two dietary periods. When analysed separately, men had a lower resting heart rate (P ¼ 0.02) and higher SEVR (P ¼ 0.05) at the end of the chilli diet than the bland diet. In the sub-study, baseline AIx on the chilli diet was lower (Po0.001) than on the bland diet, but there was no difference in the effects of GTN and salbutamol between the two diets. Conclusion: Four weeks of regular chilli consumption has no obvious beneficial or harmful effects on metabolic parameters but may reduce resting heart rate and increase effective myocardial perfusion pressure time in men.

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Section: Glyceryl Trinitrate Salbutamolmentioning

confidence: 97%

The effect of 4-week chilli supplementation on metabolic and arterial function in humans

et al. 2006

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“…However, these studies did not distinguish between a direct action of capsaicin on endothelial TRPV1 as opposed to vascular effects secondary to nerve activation. Transdermal application of capsaicin improves the ischemic threshold in patients with coronary artery disease, and this benefit is related to the augmented plasma levels of NO and thus improved arteriolar vasodilatation, events unrelated to a change in the plasma concentration of CGRP (Fragasso et al, 2004). The present study shows that short-term dietary capsaicin did not affect blood pressure, the endothelium-dependent relaxation, and PKA/eNOS phosphorylation in mesenteric arteries of SHR.…”

Section: Discussionmentioning

confidence: 99%

Activation of TRPV1 by Dietary Capsaicin Improves Endothelium-Dependent Vasorelaxation and Prevents Hypertension

et al. 2010

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SUMMARY Some plant-based diets lower the cardiometabolic risks and prevalence of hypertension. New evidence implies a role for the transient receptor potential vanilloid 1 (TRPV1) cation channel in the pathogenesis of cardiometabolic diseases. Little is known about impact of chronic TRPV1 activation on the regulation of vascular function and blood pressure. Here we report that chronic TRPV1 activation by dietary capsaicin increases the phosphorylation of protein kinase A (PKA) and eNOS and thus production of nitric oxide (NO) in endothelial cells, which is calcium dependent. TRPV1 activation by capsaicin enhances endothelium-dependent relaxation in wild-type mice, an effect absent in TRPV1-deficient mice. Long-term stimulation of TRPV1 can activate PKA, which contributes to increased eNOS phosphorylation, improves vasorelaxation, and lowers blood pressure in genetically hypertensive rats. We conclude that TRPV1 activation by dietary capsaicin improves endothelial function. TRPV1-mediated increase in NO production may represent a promising target for therapeutic intervention of hypertension.

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“…Transdermal administration of capsaicin improves the ischemic threshold in patients with stable coronary disease. 38 Our previous studies showed that TRPV1 activation by dietary capsaicin alleviates metabolic disorders and attenuates aortic atherosclerosis as well as hypertension. 21,33,39,40 In this study, we further demonstrated that chronic dietary capsaicin supplementation ameliorated HFDinduced endothelial dysfunction in the coronary arteries and prolonged the lifespan of ApoE −/− receiving HFD.…”

Section: Trpv1 Activation Antagonizes Ros-mediated Coronary Lesions Bmentioning

confidence: 99%

Ameliorating Endothelial Mitochondrial Dysfunction Restores Coronary Function via Transient Receptor Potential Vanilloid 1–Mediated Protein Kinase A/Uncoupling Protein 2 Pathway

Xiong

Wang

et al. 2016

Hypertension

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Nitric-Oxide Mediated Effects of Transdermal Capsaicin Patches on the Ischemic Threshold in Patients with Stable Coronary Disease

Abstract: Transdermal capsaicin may improve ischemic threshold in patients with stable coronary disease, probably through arteriolar vasodilation. Increased capsaicin-induced NO availability could represent the principal mechanism of action.

Cited by 21 publications

References 29 publications

The effect of 4-week chilli supplementation on metabolic and arterial function in humans

The effect of 4-week chilli supplementation on metabolic and arterial function in humans

Activation of TRPV1 by Dietary Capsaicin Improves Endothelium-Dependent Vasorelaxation and Prevents Hypertension

Ameliorating Endothelial Mitochondrial Dysfunction Restores Coronary Function via Transient Receptor Potential Vanilloid 1–Mediated Protein Kinase A/Uncoupling Protein 2 Pathway

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