“…Biofilm models predict that in general, fast growing organisms are located at the outside, while the slow growing organisms can be found at the inside of biofilms (Reichert, 1994;Wanner and Rei-chert, 1996). This phenomenon has been experimentally verified in aerobic biofilms: fast growing heterotrophic organisms are located at the outside, whereas slower growing nitrifying organisms can be found at the inside (Okabe et al, 1995;Okabe et al, 1996;Tijhuis et al, 1996;Watanabe et al, 1990). A similar structural organization has been observed in anaerobic, methanogenic granules and sulfate reducing granules as well (MacLeod et al, 1990;Ramos et al, 1994;van Houten et al, 1995).…”