Nitroenynes as Electrophiles in Organocatalysis and their Application in the Synthesis of Chiral Heterocycles

Abstract

Nitroenynes are a particular class of nitroalkenes, that have been recently used in organocatalysis. This review covers the recent examples in asymmetric catalysis using nitroenynes as electrophiles. The majority of the examples are enantioselective Michael additions, that have been categorized depending on the nucleophile, with representative examples providing insightful mechanistic details. Moreover, their applications to the synthesis of chiral heterocylces has also been discussed.