Nitroester drug’s effects and their antagonistic effects against morphine on human sphincter of Oddi motility

Wu, Shuodong; Zhang, Zhenhai; Li, Dongyan; Jin, Jun-Zhe; Kong, Jing; Zhong, Tian; Wang, Wei; Wang, Min-Fei

doi:10.3748/wjg.v11.i15.2319

Cited by 14 publications

(11 citation statements)

References 31 publications

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“…[13][14][15] Long-term duodenobiliary reflux is also considered to be one of the possible risks for the occurrence of cholangiocarcinoma. [16][17][18][19] In summary, we suggest that EST should be used with caution. For recurrent bile duct stones, we choose EST because of the loss of an opportunity to perform laparoscopic surgery.…”

Section: Discussionmentioning

confidence: 99%

A Randomized, Clinical Trial Involving Different Surgical Methods Affecting the Sphincter of Oddi in Patients With Choledocholithiasis

Yin

Gao²,

Zang³

et al. 2016

Surgical Laparoscopy, Endoscopy &Amp; Percutaneous Techniques

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Section: Discussionmentioning

confidence: 99%

A Randomized, Clinical Trial Involving Different Surgical Methods Affecting the Sphincter of Oddi in Patients With Choledocholithiasis

Yin

Gao²,

Zang³

et al. 2016

Surgical Laparoscopy, Endoscopy &Amp; Percutaneous Techniques

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“…Before and after SWA, the degree of stent occlusion was measured by means of a device previously developed and evaluated by our study group (Figure 1) [30,32]. A constant water pressure of 10 cm H 2 O, corresponding to the physiological CBD pressure, was chosen to avoid artificial wash out of encrustations [32,33]. Hence, the pathophysiologically increased CBD pressure up to 20 cm H 2 O [33] and the drainage alongside of the endoprosthesis in vivo cannot be simulated in this arrangement.…”

Section: Discussionmentioning

confidence: 99%

“…The degree of occlusion was calculated according to the formula given in Figure 2. Although physiologic CBD pressure of 10 cm H 2 O might increase up to 20 cm H 2 O in biliary obstruction [33], previous experiments showed a significant wash out of clogging material if unphysiologically increased pressure was simulated. Therefore, a constant water pressure of 10 cm H 2 O was achieved in the measuring device ( Figure 1).…”

Section: Introductionmentioning

confidence: 91%

Cleaning of occluded biliary endoprostheses: Is shockwave application an alternative to regular stent exchange?

Farnbacher

Kraupa

Schneider

2012

Journal of Medical Engineering & Technology

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Occlusion is the major limitation of plastic biliary endoprostheses (PBE), making regular stent exchange necessary. The aim of the in vitro analysis was to evaluate the cleansing effect of shockwave application (SWA) on occluded PBE. Thirty-five PBE removed from 24 patients were analyzed. Three hundred and fifty shockwave pulses were administered every 10 mm along the prosthesis stored in a liquid-filled latex balloon. Occlusion rates were measured before and after SWA. The cleansing rate was calculated in comparison to the native prosthesis. Mean occlusion rate was 76 ± 30% (Range 16-100%) before SWA. Cleansing effect was 47 ± 52% (0-100%) after SWA. Cleaning was complete (100%) in seven (20%) and satisfying (75-99%) in another seven prostheses. Degree of stent occlusion and indwelling time were significantly associated to the cleansing effect. In conclusion, SWA showed a limited cleaning effect in clogged PBE and is no suitable alternative for regular stent replacement to date.

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“…M cholinergic receptor has blocking function by inhibiting the cholinergic receptor on the smooth muscle. Our previous research had shown that Nitroester drugs and M cholinergic receptor have inhibitory effect on the SO [2,3] . It is commonly believed that morphine functions through the m acceptor.…”

Section: Discussionmentioning

confidence: 99%

Choledochoscope manometry about different drugs on the Sphincter of Oddi

Kong

Wu²,

Zhang³

et al. 2008

WJG

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AIM: To assess the effects of H 2 -receptor blocking pharmacon, protease inhibitor, and gastro kinetic agents on the human Sphincter of Oddi (SO) motility by choledochoscope manometry. METHODS: One hundred and seventy-five patients with T tube installed after cholecystectomy and choledochotomy were assessed by choledochoscope manometry. They were randomly assigned into groups of H 2 -receptor blocking pharmacon, protease inhibitor, and gastro kinetic agents. The Sphincter of Oddi basal pressure (SOBP), amplitude (SOCA), frequency of contractions (SOF), duodenal pressure (DP), and common bile duct pressure (CBDP) were scored and analyzed. RESULTS: S O B P a n d S O C A w e r e s i g n i f i c a n t l y decreased after Cimetidine administration, and no statistical difference was seen in the Famotidine group. In the Gabexate mesilate group, SOBP had decreased significantly. In the Ulinastatin group, SOCA decreased when Ulinastatin was given at the rate of 2500 U/min; when Ulinastatin administration was raised to 5000 U/ min, SOBP, SOF and SOCA all experienced a fall. SOBP and SOCA for Domperidone and SOCA for Mosapride groups all decreased distinctly after administration. CONCLUSION: The regular dosage of Cimetidine showed an inhibitory effect on the motility of SO, while Famotidine had no obvious effects otherwise. Gabnexata mesilate, Ulinastatin and gastro kinetic agents also showed inhibitory effects on the SO motility.

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Nitroester drug’s effects and their antagonistic effects against morphine on human sphincter of Oddi motility

Abstract: The regular dose of GTN, ISDN and PTN showed inhibitory effect on SO motility, morphine showed excitatory effect on SO while GTN, ISDN and PTN could antagonize the effect of morphine. Among the three nitroester drugs, the effect of ISDN on SO was most significant.

Cited by 14 publications

References 31 publications

A Randomized, Clinical Trial Involving Different Surgical Methods Affecting the Sphincter of Oddi in Patients With Choledocholithiasis

A Randomized, Clinical Trial Involving Different Surgical Methods Affecting the Sphincter of Oddi in Patients With Choledocholithiasis

Cleaning of occluded biliary endoprostheses: Is shockwave application an alternative to regular stent exchange?

Choledochoscope manometry about different drugs on the Sphincter of Oddi

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