Nitrogen Atmospheric Pressure Post Discharges for Surface Biological Decontamination inside Small Diameter Tubes

Pointu, A. M.; Ricard, A.; Odic, Emmanuel; Ganciu, M.

doi:10.1002/ppap.200800016

Cited by 41 publications

(53 citation statements)

References 19 publications

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“…While one of the main directions pursued for the application of nonthermal plasma technologies is the sterilization of heatsensitive medical equipment, such as catheters [4], [47], [91], [92], another one is the reduction of bacterial loads or even the complete decontamination of wounds [66], [93]- [99]. With the ability of operation using ambient air, the microhollow cathodebased plasma jet holds particular appeal for use in environments where resources are scarce.…”

Section: Introductionmentioning

confidence: 99%

Cold DC-Operated Air Plasma Jet for the Inactivation of Infectious Microorganisms

Kolb

Mattson

Edelblute

et al. 2012

IEEE Trans. Plasma Sci.

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We evaluated a nonthermal plasma jet for a respective use to prevent infections from bacteria and yeasts. The plasma jet is generated from the flow of ambient air with 8 slm through a microhollow cathode discharge assembly that is operated with a direct current of 30 mA. With these parameters, the temperature in the jet reaches 43 • C at 10 mm from the discharge. Agar plates that were inoculated with Staphylococcus aureus, Pseudomonas aeruginosa, Acinetobacter baumannii, and Candida kefyr were treated at this distance, moving the plates through the jet in a meander that covered a 2 cm by 2 cm area. Different exposure times were realized by changing the speed of the movement and adjusting the distance between consecutive passes. S. aureus was most responsive to the exposure with a reduction in the number of colony forming units of 5.5 log steps in 40 s. All other microorganisms show a more gradual inactivation with exposure times. For all bacteria, a clearing of the treated area is achieved in about 2.5-3.5 min, corresponding to log-reduction factors of 5.5-6.5. Complete inactivation of the yeast requires about 7 min. Both S. aureus and C. kefyr show considerable inactivation also outside the immediate treatment area, while P. aeruginosa and A. baumannii do not. We conclude that differences in the morphologies of the membrane structures are responsible for the diverging results, together with a targeted response to different agents provided with the plasma jet. For the gram negative bacteria, we hold short-lived agents, acting across a short range, responsible, while for the other microorganisms, longer lived species seem more important. Our measurements show that neither heat, ultraviolet radiation, nor the generation of ozone can be responsible for the observed results. The most prominent long lived reaction product found is nitric oxide, which, by itself or through induced chemical reactions, might affect cell viability.

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Section: Introductionmentioning

confidence: 99%

Cold DC-Operated Air Plasma Jet for the Inactivation of Infectious Microorganisms

Kolb

Mattson

Edelblute

et al. 2012

IEEE Trans. Plasma Sci.

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“…Since polyethylene tubes are very important and widespread products in everyday life, the interest to improve the surface characteristics of these tubes is significantly growing. An increasing amount of articles is currently being published dealing with the problem of inner tube sterilization for medical applications . As an example, Polak et al have shown that a DBD set‐up placed around a tube can provide a significant plasma penetration inside tubes of 5 m .…”

Section: Introductionmentioning

confidence: 99%

Atmospheric Pressure Plasma Penetration inside Flexible Polymeric Tubes

Onyshchenko

Nikiforov

Morent

2015

Plasma Process. Polym.

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An atmospheric argon plasma jet has been used to explore the plasma penetration inside tubes of small diameter and the plasma treatment effect on the inner tube surface. The goal of this paper is to show how the tube size can influence the plasma jet penetration and the resulting surface effects on polyethylene tubes with diameters varying between 0.28 mm and 3.00 mm. Optical emission spectroscopy and light emission images have been used to investigate the distribution of active species along the tube length. To examine the plasma treatment effect on the inner tube surface, capillary action, water contact angle measurements and XPS analysis have been used. The results presented in this paper will clearly demonstrate the great potential of atmospheric pressure plasma jets for inner tube surface modification.

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“…Cold atmospheric pressure plasmas have a huge potential for the sterilization of such complex medical devices and therefore are of great scientific and hygienic interest 7. Typically, endoscope biopsy channels are made of polytetrafluoroethylene (PTFE) or fluorinated ethylene propylene (FEP) and have inner diameters within the range of 1–2 mm, whereas the tube length is mostly longer than 1 m. Several concepts for plasma ignition in long and narrow tubes are discovered in the last few years, ranging from the ignition of a dielectric barrier discharge (DBD) by means of an outer and an inner‐tube electrode up to the usage of afterglow plasmas or plasma bullets 8–10…”

Section: Introductionmentioning

confidence: 99%

Innovative Plasma Generation in Flexible Biopsy Channels for Inner‐Tube Decontamination and Medical Applications

Polák¹,

Winter

Schnabel

et al. 2011

Plasma Processes & Polymers

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An innovative device capable of generating a cold atmospheric pressure plasma inside a 5 m long flexible tube with 2 mm inner diameter is presented. In order to analyze the inner‐tube plasma, optical emission spectroscopy in the (vacuum) ultraviolet spectral range and Fourier transformed infrared spectroscopy were performed. By admixing small concentrations of nitrogen and oxygen to the standard argon gas flow rate of 1.5 slm, a drastically change in the plasma composition was observed. Additionally, it is possible to form a jet‐like plasma at the end of the tube. The microbicidal efficacy of the inner‐tube plasma and the jet‐like plasma was shown for Bacillus atrophaeus spores.

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Nitrogen Atmospheric Pressure Post Discharges for Surface Biological Decontamination inside Small Diameter Tubes

Cited by 41 publications

References 19 publications

Cold DC-Operated Air Plasma Jet for the Inactivation of Infectious Microorganisms

Cold DC-Operated Air Plasma Jet for the Inactivation of Infectious Microorganisms

Atmospheric Pressure Plasma Penetration inside Flexible Polymeric Tubes

Innovative Plasma Generation in Flexible Biopsy Channels for Inner‐Tube Decontamination and Medical Applications

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