The reported effects of nitrogen (N) fertilizer on wheat yield and nitrogen use efficiency (NUE) vary greatly, due to differences in climate, soil factors, and N management practices in different regions of China. We collected literature published during 1950-2017 that reported the yield and NUE for wheat in China, under N application and control treatments, and analyzed the data therein. A significant increase in yield was observed with N application, and varied with climate, soil factors, and N management practices in different regions. A larger increase in yield was observed under an average annual temperature of 13-15 • C, an average annual precipitation of >800 mm, respectively. Greater yield-increasing effects were observed in soil with a coarse soil texture, lower soil total N, available N, and a soil pH of ≤7 and >8, respectively. In Northwest China, the yield increase was greater under multiple coated urea applications after anthesis, while the higher NUE was observed under single coated urea application before anthesis. In North China, the yield and NUE were greater under multiple coated urea applications before anthesis. In South China, the yield and NUE were greater under multiple N applications. Consequently, to improve wheat yield and NUE, site-specific N management practices should be adopted.