Nitroprusside induces melanoma ferroptosis with serum supplementation and prolongs survival under serum depletion or hypoxia

Gomez-Sarosi, Luis; Rieber, Manuel

doi:10.1016/j.bbrc.2020.02.107

Cited by 3 publications

(2 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In order to illuminate whether cancer cells undergo either ferroptosis death or resistance to it, nitroprusside was approved to produce O 2 and H 2 O 2 and then react with iron to mediate ferroptosis of melanoma cells. 162 On this basis, albuminbinding dimeric prodrug nanoparticles (NPs) were constructed with hypoxia-sensitive 2-nitroimidazole-modified carboxymethyl chitosan, which can be applied in combating hypoxiainduced metastasis of lung cancers. 163 These studies suggest that conquering hypoxia by stimulating ferroptosis nanotherapeutics is an effective approach to overcome drug resistance of tumors.…”

Section: Ferroptosis-driven Nanotherapeutics Triggered By Tumor Micro...mentioning

confidence: 99%

Ferroptosis-Driven Nanotherapeutics to Reverse Drug Resistance in Tumor Microenvironment

Zhu

Meng

Wang

et al. 2022

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

Ferroptosis, characterized by iron-dependent lipid reactive oxygen species (ROS) accumulation, is non-apoptotic programmed cell death highly relevant to tumor development. It was found to manipulate oncogenes and resistant mutations of cancer cells via lipid metabolism pathways converging on phospholipid glutathione peroxidase (GPX4) that squanders lipid peroxides (L-OOH) to block the iron-mediated reactions of peroxides, thus rendering resistant cancer cells vulnerable to ferroptotic cell death. By accumulating ROS and lipid peroxidation (LPO) products to lethal levels in tumor microenvironment (TME), ferroptosis-driven nanotherapeutics show a superior ability of eradicating aggressive malignancies than traditional therapeutic modalities, especially for the drug-resistant tumors with high metastasis tendency. Moreover, Fenton reaction, inhibition of GPX-4, and exogenous regulation of LPO are three major therapeutic strategies to induce ferroptosis in cancer cells, which were generally applied in ferroptosis-driven nanotherapeutics. In this review, we elaborate current trends of ferroptosisdriven nanotherapeutics to reverse drug resistance of tumors in anticancer fields at the intersection of cancer biology, materials science, and chemistry. Finally, their challenges and perspectives toward feasible translational studies are spotlighted, which would ignite the hope of anti-resistant cancer treatment.

show abstract

Section: Ferroptosis-driven Nanotherapeutics Triggered By Tumor Micro...mentioning

confidence: 99%

Ferroptosis-Driven Nanotherapeutics to Reverse Drug Resistance in Tumor Microenvironment

Zhu

Meng

Wang

et al. 2022

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

show abstract

“…Its mechanism is that overloaded iron divalent ions in the cell make the cell produce a large number of lipid reactive oxygen species (ROS), which leads to the accumulation of lipid peroxides and induces ferroptosis. Studies have found that ferroptosis is generally inhibited in lung cancer cells, and the molecular mechanisms involved are not fully understood (6)(7)(8). Inducing cell death is considered a viable cancer treatment, and ferroptosis is also considered a potential therapeutic strategy to trigger cancer cell death, especially for malignancies that are resistant to conventional therapies (9).…”

Section: Introductionmentioning

confidence: 99%

Bioinformatics analysis based on ferroptosis-related lncRNAs: construction of a clinical prognostic model for nasopharyngeal carcinoma and correlation analysis

Dai

Zhong

2022

Transl Cancer Res TCR

View full text Add to dashboard Cite

Background: A prognostic model of ferroptosis associated with long non-coding RNAs (lncRNAs) in nasopharyngeal carcinoma was established by using The Cancer Genome Atlas (TCGA) database, and immune correlation analysis was conducted for patients classified into high-and low-risk groups by the model. Nasopharyngeal carcinoma is associated with many lncRNA gene mutations, and tumors are often closely related to metabolism, accompanied by obvious characteristics of immune infiltration.Methods: Gene expression data and clinical data of nasopharyngeal carcinoma tissues and normal tissues were obtained from TCGA database, and differential lncRNAs related to ferroptosis were screened out.Univariate and multivariate Cox risk regression models were used to screen and establish the lncRNA prognostic risk prediction model. Patients were scored according to the model. The immune-related functions of the high-risk and low-risk groups were compared to obtain immune-related differences between the groups. In this study, the prognostic model was constructed by the intersection of genes related to nasopharyngeal cancer prognosis and genes related to iron death metabolism through Cox regression analysis and R-packet screening, and the area under curve (AUC) was further used to predict and verify the model. Results:In this study, a total of 14 differential lncRNAs related to the prognosis of ferroptosis were obtained. Immune correlation analysis showed that the high-and low-risk groups had significant differences in the following factors: dendritic cells, B cells, mast cells, and other immune cells (P=0.0001); anaphasepromoting complex (APC) co-inhibition, chemotactic factor receptor, immune checkpoint, and other immune functions (P=0.002); glutamate cysteine ligase catalytic (GCLC), human endogenous retrovirus-H long terminal repeat-associating protein 2 (HHLA2), cluster of differentiation (CD276), B and T-lymphocyte attenuator (BTLA), and other immune checkpoint related genes (P<0.001). GCLC was highly expressed in NP69/DDP cells (P=0.04). DDP can activate ferroptosis in NP69/DDP cells can inhibit GCLC expression, and the AUC curve (AUC =0.899) indicates that the model has good prediction and accuracy. Conclusions:The prognostic model based on 16 ferroptosis-related lncRNAs can predict the prognosis of nasopharyngeal carcinoma patients, and the ferroptosis-related lncRNAs involved in the construction of the model obtained in this study may be related to the level of immune infiltration, and may even become new targets for immune checkpoint inhibitor therapy.

show abstract

Ferroptosis as a mechanism of non-ferrous metal toxicity

et al. 2022

View full text Add to dashboard Cite

Nitroprusside induces melanoma ferroptosis with serum supplementation and prolongs survival under serum depletion or hypoxia

Cited by 3 publications

References 44 publications

Ferroptosis-Driven Nanotherapeutics to Reverse Drug Resistance in Tumor Microenvironment

Ferroptosis-Driven Nanotherapeutics to Reverse Drug Resistance in Tumor Microenvironment

Bioinformatics analysis based on ferroptosis-related lncRNAs: construction of a clinical prognostic model for nasopharyngeal carcinoma and correlation analysis

Ferroptosis as a mechanism of non-ferrous metal toxicity

Contact Info

Product

Resources

About