Nitrous oxide use in first-year students at Auckland University

Ng, Jennifer; O’Grady, Gregory; Pettit, Tristan; Frith, Richard

doi:10.1016/s0140-6736(03)13045-0

Cited by 64 publications

(47 citation statements)

References 2 publications

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“…8 In 2004, an estimated 400 000 Australians reported ever having used inhalants and 1 in 250 reported using in the previous 12 months. 9 Ng et al 10 recently reported that 12% of students from engineering, law and health degrees at Auckland University inhaled N 2 O for recreational purposes.…”

Section: Discussionmentioning

confidence: 99%

A case of unusual substance abuse causing myeloneuropathy

2006

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Section: Discussionmentioning

confidence: 99%

A case of unusual substance abuse causing myeloneuropathy

2006

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“…70 Repeated exposure can produce severe neuropsychiatric damage regardless of preexisting cobalamin status. 71 …”

Section: Cobalamin Prophylaxis In Clinical Practicementioning

confidence: 99%

How I treat cobalamin (vitamin B12) deficiency

Carmel

2008

Blood

291

233

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The challenges in medical management of cobalamin deficiency lie in attention to the unique pathophysiology that underlies cobalamin deficiency, more than in the mechanics of therapy. The central physiologic principles are that clinically important deficiency is more likely to occur (and progress) when intrinsic factor-driven absorption fails than when diet is poor and that most causes take years to produce clinically obvious deficiency. Transient defects have little clinical impact. The key management principle is the importance of follow-up, which also requires knowing how the deficiency arose. The virtues of these principles are not always fully appreciated. Recent developments have made diagnosis and management more difficult by diminishing the ability to determine cobalamin absorption status. Clinicians must also grapple with premature medicalization of isolated, mild biochemical changes that added many asymptomatic cases of still undetermined medical relevance to their caseload, often expanded by inflated cobalamin level criteria. The potential for misattribution of cobalamin-unrelated presentations to nongermane cobalamin and metabolite abnormalities has grown. Pathophysiologically based management requires systematic attention to each of its individual components: correctly diagnosing cobalamin deficiency, reversing it, defining its underlying cause, preventing relapse, managing the underlying disorder and its complications, and educating the patient. (Blood. 2008;112: 2214-2221)

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“…The inhalation results in oxygen depletion in the body which can lead to lethal intoxication via asphyxiation. Regularly referred to as 'laughing gas', it's increasing abuse has led to hospitalization and deaths described in published case reports after accidental inhalation [1], occupational exposure [2][3][4], post-operative effects [5][6][7][8] and inhalation abuse [9][10][11][12][13]. It is understood that the toxic effects associated with N 2 O are caused by the interaction with vitamin B 12 or the B 12 coenzyme.…”

Section: Introductionmentioning

confidence: 99%