Nivolumab-induced and radiation recall pneumonitis in patients with non-small cell lung cancer: A multicenter real world analysis of 669 patients

Mamesaya, Nobuaki; Narita, Shintaro; Naito, Tomoyuki; Udagawa, Hibiki; Goto, Kōichi; Miyawaki, Taichi; Nakashima, Kazuhisa; Kenmotsu, Hirotsugu; Shimokawaji, Tadasuke; Kato, Terufumi; Hakozaki, Taiki; Okuma, Yusuke; Nakayama, Yuko; Kusumoto, Masahiko; Ohe, Yui; Horinouchi, Hidehito

doi:10.1093/annonc/mdz260.029

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“…Numerous studies have shown that age is a risk factor that results in susceptibility to infection after surgical treatment (7,8). Secondly, the relationship between postoperative infection and length of hospitalization could be attributable to the fact that patients with a longer hospitalization time have more serious illnesses, are in contact with other patients during hospitalization, and undergo an increased number of invasive operations, which can easily lead to nosocomial infection (9). Thirdly, the relationship between postoperative infection and comorbid diseases could be due to the fact that patients with underlying diseases typically have lower physical fitness and are more likely to develop infections after surgical treatment.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the pathogenic bacteria, drug resistance, and risk factors of postoperative infection in patients with non-small cell lung cancer

Chen¹,

Wen²,

Chen³

et al. 2021

Ann Palliat Med

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Background:To analyze the pathogenic bacteria, drug resistance, and risk factors of postoperative infection in patients with non-small cell lung cancer (NSCLC).Methods: A total of 119 patients with NSCLC who were admitted to our hospital from January 2017 to March 2020 were selected. The patients' clinical data were collected to evaluate the postoperative infection.The pathogenic bacteria, drug resistance, and risk factors of postoperative infections in patients with NSCLC were analyzed.Results: Among 119 patients, 33 cases (27.73%) had postoperative infection, and 86 cases (72.28%) had no infection. In total, 81 pathogens were isolated from the secretions via bacterial culture from the infected sites of the 33 patients. Of these, 43 (53.09%) were gram-negative bacteria, 34 (41.98%) were Grampositive bacteria, and four (4.94%) were fungi. Postoperative gram-negative infection showed the highest resistance rate to ciprofloxacin (81.39%), and the drug resistance rate to imipenem and meropenem was low (9.30% and 4.65%, respectively). Postoperative gram-positive infection exhibited the highest resistance rate to erythromycin (82.35%), and the drug resistance rate to vancomycin was low (5.88%). According to the univariate analysis, there were differences between the two groups in age, length of hospitalization, combined diseases, operation time, invasive procedures, hemoglobin, and serum albumin (P<0.05). However, there were no differences in terms of gender, TNM staging, and pathological classification (P<0.05). Based on the unconditional multivariate logistic regression model analysis, age ≥60 years, hospitalization time >30 d, combined diseases, operation time ≥3 h, hospitalization time >30 d, invasive operation, hemoglobin ≤90 g/L, and serum albumin ≤30 g/L were independent risk factors leading to postoperative infection in patients with NSCLC (P<0.05). Conclusions:The postoperative infection rate of patients with NSCLC is high. gram-negative bacteria infection is the primary infection in patients. There are many factors that cause postoperative infections in patients, and it is necessary to strictly control these risk factors in clinical practice, which is an effective means to prevent postoperative infection. 2 Chen et al. Analysis of postoperative infection in patients with NSCLC

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Section: Discussionmentioning

confidence: 99%