NK cells at the interface between innate and adaptive immunity

NK Cells Influence Both Innate and Adaptive Immune Responses after Mucosal Immunization with Antigen and Mucosal Adjuvant

“…Another study has highlighted the importance of NK-DC cellular interactions in vivo within the lymph nodes of mice infected with Leishmania major and the consequent activation of CD4 + T cells (27). Other evidence indicates that early IFN-g production by NK cells can affect the characteristics of Ag-specific immune response, particularly by driving T H 1 polarization (28)(29)(30)(31).…”

Dendritic cells in cancer immunotherapy

“…At this point, many factors remain to be systemically tested, including the dose, frequency, and route of DC vaccine administration, let alone the many ideas and possibilities arising from DC biology. DC, depending on their subset and maturation status, can induce and activate all kinds of T cells (including Treg), B cells, and antibodies [36], NKT [47,48] and NK cells [49][50][51][52], in principle allowing a broad ''coordinated antitumor response'' [53]. With respect to clinical testing, one priority is the induction of strong T-cell responses, which in my view has yet to be achieved.…”

The anti-tumoral drug enzastaurin inhibits natural killer cell cytotoxicity via activation of glycogen synthase kinase-3β

“…1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 4 armed with an array of activating receptors that trigger cytolytic granules and cytokine production. Besides expression of several receptors that mediate natural cytotoxicity, NK cells also express CD16 which mediates antibody-dependent cellular cytotoxicity (ADCC) against IgG-coated target cells [10][11][12][13]. While NK cell activating receptors like NKp30, NKp44, NKp46, and CD16 associate with the transmembrane adaptors CD3δ, FcRγ, or DAP12 that contain a cytoplasmic immunoreceptor tyrosine-based activation motif (ITAM) [14], NKG2D associates with the adaptor protein DAP10 which contains a cytoplasmic YINM motif [15][16][17][18][19].…”