NLK, a novel target of miR-199a-3p, functions as a tumor suppressor in colorectal cancer

Han, Yongtao; Kuang, Yuting; Xue, Xiaofeng; Guo, Xinfeng; Li, Pu; Wang, Xu; Guo, Xingpo; Yuan, Bin; Zhi, Qiaoming; Zhao, Hong

doi:10.1016/j.biopha.2014.05.003

Cited by 33 publications

(27 citation statements)

References 27 publications

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“…The only unconfirmed miRNA was hsa-mir-199a. As a matter of fact, evidences have demonstrated that hsa-mir-199a plays a critical role in the cell biological behaviors of colorectal cancer through its target genes[59]. Our prediction results were consistent with existing findings and provided computational evidence for its association with CN.…”

Section: Resultssupporting

confidence: 88%

GLNMDA: a novel method for miRNA-disease association prediction based on global linear neighborhoods

Liang

Xiao

et al. 2018

RNA Biology

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Recently, increasing studies have shown that miRNAs are involved in the development and progression of various complex diseases. Consequently, predicting potential miRNA-disease associations makes an important contribution to understanding the pathogenesis of diseases, developing new drugs as well as designing individualized diagnostic and therapeutic approaches for different human diseases. Nonetheless, the inherent noise and incompleteness in the existing biological datasets have limited the prediction accuracy of current computational models. To solve this issue, in this paper, we propose a novel method for miRNA-disease association prediction based on global linear neighborhoods (GLNMDA). Specifically, our method obtains a new miRNA/disease similarity matrix by linearly reconstructing each miRNA/disease according to the known experimentally verified miRNA-disease associations. We then adopt label propagation to infer the potential associations between miRNAs and diseases. As a result, GLNMDA achieved reliable performance in the frameworks of both local and global LOOCV (AUCs of 0.867 and 0.929, respectively) and 5-fold cross validation (average AUC of 0.926). Case studies on five common human diseases further confirmed the utility of our method in discovering latent miRNA-disease pairs. Taken together, GLNMDA could serve as a reliable computational tool for miRNA-disease association prediction.

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Section: Resultssupporting

confidence: 88%

GLNMDA: a novel method for miRNA-disease association prediction based on global linear neighborhoods

Liang

Xiao

et al. 2018

RNA Biology

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“…For instance, in human colon cancer overexpression of NLK in DLD-1 human colon cancer cell line could induce apoptosis and inhibit cell growth [9]. Moreover, NLK expression was significantly downregulated in colorectal cancer (CRC) tumor tissues than adjacent nontumor tissues [16]. Overexpression of NLK could induce apoptosis and inhibit androgen receptor-mediated transcription in human prostate cancer cells [17].…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of Nemo-like kinase expression in patients with hepatocellular carcinoma

Chen

Qiao

et al. 2015

Tumor Biol.

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Nemo-like kinase (NLK) is an evolutionarily conserved serine/threonine protein kinase and belongs to the extracellular signal-regulated kinases/microtubule-associated protein kinase families (Erks/MAPKs). Previous studies have indicated that abnormal expressions of NLK played critical roles in various types of human cancers. Recent studies suggested that NLK expression was significantly upregulated in the hepatocellular carcinoma (HCC) specimens. However, the clinical significance of NLK expression in HCC remains largely unknown. In this study, we focused on the clinical significance of NLK in HCC and found that high expression of NLK was significantly associated with Edmondson-Steiner grade (P = 0.002), tumor size (P = 0.022), and no. of tumor nodules (P < 0.001), and NLK was positively correlated with proliferation marker Ki-67 (P < 0.01). Univariate analysis suggested that NLK expression was associated with poor prognosis (P < 0.001). Multivariate analysis indicated that NLK expression was an independent prognostic indicator for HCC (P = 0.0370). In conclusion, NLK overexpression is associated with poor overall survival in patients with HCC, it might be an independent poor prognostic marker for HCC.

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“…Ectopic overexpression of miR-101 represses cell growth and proliferation and imitates NLK knockdown effect on HCC cells [28]. NLK is confirmed as a target of miR-199a-3p, and downregulated NLK amplifies proliferation, migration, and invasion and prevents apoptosis in CRC cells [18]. miR-197 can promote Taxol resistance, cell proliferation, and invasion of ovarian cancer cells by regulating NLK expression [29].…”

Section: Upstream Regulators Of Nlk In Cancersmentioning

confidence: 96%

“…A significant decrease of NLK mRNA level evaluated by quantitative real-time polymerase chain reaction (qRT-PCR) is observed in colorectal cancer (CRC) patients with a median change by about 0.56-fold compared with the non-tumor tissues, and the low NLK expression group has a significantly shorter overall survival rate than that of the high NLK expression group [18]. However, conflicting findings are reported by Chen et al recently.…”

Section: Altered Expression Of Nlk In Cancersmentioning

confidence: 99%

The emerging role of Nemo-like kinase (NLK) in the regulation of cancers

Huang

Yang

et al. 2015

Tumor Biol.

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Nemo-like kinase (NLK) is an evolutionarily conserved mitogen-activated protein (MAP) kinase-related kinase that is highly expressed in neural tissues and minimally detected in others. Accumulating evidence demonstrates that NLK exerts a pivotal role in cell proliferation, migration, invasion, and apoptosis via regulation of a variety of transcriptional molecules. The results of recent studies have shown that aberrant expression of NLK is significantly associated with the initiation and progression of various types of human cancers, as well as clinicopathologic features and survival rate. NLK is gradually considered as a potential tumor suppressor or an oncogene depending on the tumor system, and silencing or upregulating of NLK may provide an effective therapeutic approach against tumors. In this review, we will make a summary on the comprehensive roles of NLK in the regulation of various cancers.

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NLK, a novel target of miR-199a-3p, functions as a tumor suppressor in colorectal cancer

Cited by 33 publications

References 27 publications

GLNMDA: a novel method for miRNA-disease association prediction based on global linear neighborhoods

GLNMDA: a novel method for miRNA-disease association prediction based on global linear neighborhoods

Prognostic significance of Nemo-like kinase expression in patients with hepatocellular carcinoma

The emerging role of Nemo-like kinase (NLK) in the regulation of cancers

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