NMR Studies of Host–Guest Complexes of Anionic Cyclophanes with Dopamine and Its Analogues in Aqueous Media

Virués, Claudia; Velázquez, Enrique F.; Inoue, Michiko; Inoue, Motomichi

doi:10.1023/b:jiph.0000022521.83082.b0

Cited by 15 publications

(6 citation statements)

References 15 publications

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“…A variety of groups, such as pyridinium,73, 74 ammonium,75, 76 carboxylic,77 phosphonic moieties, and saccharides, have been used to solubilize cyclophane scaffolds in water. The presence of adamantyl substituents and subsequent complexation with β‐cyclodextrins also significantly increases the solubility of cyclophanes in water 78.…”

Section: Cyclophanesmentioning

confidence: 99%

Supramolecular Chemistry in Water

2007

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Supramolecular chemistry in water is a constantly growing research area because noncovalent interactions in aqueous media are important for obtaining a better understanding and control of the major processes in nature. This Review offers an overview of recent advances in the area of water-soluble synthetic receptors as well as self-assembly and molecular recognition in water, through consideration of the functionalities that are used to increase the water solubility, as well as the supramolecular interactions and approaches used for effective recognition of a guest and self-assembly in water. The special features and applications of supramolecular entities in aqueous media are also described.

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Section: Cyclophanesmentioning

confidence: 99%

Supramolecular Chemistry in Water

2007

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“…The macrocyclic compound 148 could easily include aromatic amine guests such as dopamine, tyramine and phenyl ethylamine [276] . In order to improve its selectivity, considering the hydrophobicity of cavity and steric conformational restriction, the substituent groups R 1 and R 2 of 148 were changed to afford their corresponding derivatives with better selectivity to dopamine.…”

Section: Supermolecules As Other Pharmaceutical Agentsmentioning

confidence: 99%

Review on supermolecules as chemical drugs

Zhou

Gan

Zhang

et al. 2009

Sci. China Ser. B-Chem.

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Supramolecular medicinal chemistry field has been a quite rapidly developing, increasingly active and newly rising interdiscipline which is the new expansion of supramolecular chemistry in pharmaceutical sciences, and is gradually becoming a relatively independent scientific area. Supramolecular drugs could be defined as medicinal supermolecules formed by two or more molecules through noncovalent bonds. So far a lot of supermolecules as chemical drugs have been widely used in clinics. Supermolecules as chemical drugs, i.e. supramolecular chemical drugs or supramolecular drugs, which might have the excellences of lower cost, shorter period, higher potential as clinical drugs for their successful research and development, may possess higher bioavailability, better biocompatibility and drug-targeting, fewer multidrug-resistances, lower toxicity, less adverse effect, and better curative effects as well as safety, and therefore exhibit wide potential application. These overwhelming advantages have drawn enormous special attention. This paper gives the definition of supramolecular drugs, proposes the concept of supramolecular chemical drugs, and systematically reviews the recent advances in the research and development of supermolecules, including organic and inorganic complex ones as chemical drugs in the area of antitumor, anti-inflammatory, analgesic, antimalarial, antibacterial, antifungal, antivirus, anti-epileptic, cardiovascular agents and magnetic resonance imaging agents and so on. The perspectives of the foreseeable future and potential application of supramolecules as chemical drugs are also presented.

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“…Um wasserlösliche Cyclophane zu erhalten, wurden unterschiedliche Gruppen eingeführt, unter anderem Pyridinium-, [73,74] Ammonium-, [75,76] Carboxy- [77] und Phosphonogruppen sowie Saccharide. Auch die Einführung von Adamantylsubstituenten und die anschließende Komplexbildung mit b-Cyclodextrinen erhöht die Löslichkeit von Cyclophanen in Wasser erheblich.…”

Section: Cyclophane Mit Mehreren (Hetero-)areneinheiten Und Unterschiunclassified

Supramolekulare Chemie in Wasser

2007

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Die supramolekulare Chemie in Wasser ist ein ständig wachsendes Forschungsgebiet, da nichtkovalente Wechselwirkungen in wässrigen Medien entscheidend für ein besseres Verständnis und die Kontrolle grundlegender Prozesse in der Natur sind. Dieser Aufsatz bietet einen Überblick über aktuelle Entwicklungen auf den Gebieten der wasserlöslichen synthetischen Rezeptoren, der Selbstorganisation und der molekularen Erkennung in Wasser unter Berücksichtigung von Funktionalitäten, die zur Verbesserung der Wasserlöslichkeit eingeführt werden, sowie der supramolekularen Wechselwirkungen und der Methoden, die für eine effiziente Gasterkennung und Selbstorganisation in Wasser eingesetzt werden. Zudem beschreibt er die besonderen Eigenschaften und Anwendungsmöglichkeiten supramolekularer Einheiten in wässrigen Medien.

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NMR Studies of Host–Guest Complexes of Anionic Cyclophanes with Dopamine and Its Analogues in Aqueous Media

Cited by 15 publications

References 15 publications

Supramolecular Chemistry in Water

Supramolecular Chemistry in Water

Review on supermolecules as chemical drugs

Supramolekulare Chemie in Wasser

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