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Moschos, Michael; Apostolopoulos, Michael; Ladas, John G.; Theodossiadis, P. G.; Malias, John; Moschou, Marilita; Papaspirou, Alexis; Theodossiadis, George

doi:10.1023/a:1017507220510

Cited by 21 publications

(6 citation statements)

References 12 publications

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“…Previous studies in the use of mfERG in assessing macular hole have found that the first-order mfERG response amplitudes were reduced in the areas corresponding to the macular hole and the mfERG abnormalities were mostly localized to the central macula [10][11][12]. Consistent with previous studies, our results demonstrated that the firstorder mfERG N1 and P1 amplitudes were limited to the central two rings.…”

Section: Discussionsupporting

confidence: 91%

“…On the other hand, mfERG can provide objective functional assessment of eyes with macular hole and it can demonstrate the extent of macular dysfunction topographically with reduced response amplitudes at the central macula [7]. Several studies have demonstrated that reductions in first-order mfERG response amplitudes are mostly localized to the central macula [8][9][10]. However, previous mfERG studies that evaluated patients with macular hole mainly focused on the assessment of the first-order mfERG responses, and the second-order mfERG responses have not been assessed.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Changes in first- and second-order multifocal electroretinography in idiopathic macular hole and their correlations with macular hole diameter and visual acuity

Yip

Fok

Ngai

et al. 2009

Graefes Arch Clin Exp Ophthalmol

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Changes in first- and second-order multifocal electroretinography in idiopathic macular hole and their correlations with macular hole diameter and visual acuity

Yip

Fok

Ngai

et al. 2009

Graefes Arch Clin Exp Ophthalmol

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“…Although both BCVA and mfERG responses improved incrementally after surgery [ Figure 4 ], they were not found to be statistically correlated at each evaluation time point of our short-term observation [ Figure 5 ] as well as in previous longer term studies concerning conventional surgical technique (just ILM peeling but without inverting) in treatment of MHs. [ 21 22 23 ] The lack of correlation between BCVA and mfERG responses suggested that these two functional evaluation modalities could not adequately represent, but might be supplemental to, each other in the clinical setting of MHs, and might be explained by the following differences between them: BCVA is a subjective measurement and only measure the function of the fixation point under optimal condition, while mfERG is an objective measurement and provides a topographic electrophysiological mapping of the central retina. Further studies combining BCVA, OCT, mfERG, and subjective functional mapping of the central retina, such as microperimetry, might provide a more comprehensive evaluation of the patients with MHs.…”

Section: Discussionmentioning

confidence: 99%

Inverted Internal Limiting Membrane Flap Technique for Repair of Large Macular Holes

Chen

Zhao

et al. 2016

Chinese Medical Journal

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Background:Inverted internal limiting membrane (ILM) flap technique has recently been reported in a limited number of studies as an effective surgical technique for the management of large macular holes (MHs) with fair MH closure rates as well as gains in visual acuity. In the current study, longitudinal changes in multi-focal electroretinogram (mfERG) responses, best-corrected visual acuity (BCVA) and spectral-domain optical coherence tomography (SD-OCT) were evaluated in eyes with large MHs managed by this technique.Methods:A prospective noncontrolled interventional study of eight patients (eight eyes) with large MHs (minimum diameter >400 μm) was conducted. All MHs were treated with pars plana vitrectomy and indocyanine green-assisted inverted ILM flap technique. SD-OCT images were used to assess the anatomical outcomes of surgery while BCVA and mfERG were used to evaluate the functional outcomes during a 3-month follow-up.Results:All patients underwent successful intended manipulation and translocation of the ILM flap without flap dislocation and achieved complete anatomical closure. Partial microstructural reconstruction, demonstrated on SD-OCT as restoration of the external limiting membrane and the ellipsoid zone, was observed in all cases as early as 1 month after surgery. Functionally, as compared to baseline, all patients showed improvements in BCVA and all but one in mfERG response during follow-up. However, Pearson's test revealed no significant correlations between BCVA and mfERG responses of the fovea and of the macular area at each evaluation time point.Conclusions:Inverted ILM flap technique appeares to be a safe and effective approach for the management of large idiopathic MHs with favorable short-term anatomical and functional results. Postoperative reconstruction of the microstructure generally shows good consistency with improvements in both BCVA and mfERG response, of which the latter might be a supplement for the former in postoperative functional follow-up.

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“…Previous authors have reported varied results about the role of mfERG in macular hole. A positive correlation was seen between the postoperative visual acuity and mfERG amplitudes, however, the amplitudes tended to vary greatly even in patients with the same level of acuity (Si et al, 1999;Moschos et al, 2001). Conversely, improvement in ERG amplitudes were noted even with unchanged visual acuities after macular hole closure (Si et al, 1999).…”

Section: Discussionmentioning

confidence: 88%

Macular function assessment by multifocal electroretinogram and microperimetry in macular hole and correlation with visual acuity

et al. 2020

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Background: Functional outcome of macular hole (MH) surgery can be better assessed with multifocal electroretinogram (mfERG) and microperimetry (MP). It might provide better assessment than the Snellen visual acuity alone. Objectives: To evaluate macular function with mfERG and microperimetry, and assess their correlation with visual acuity in MH. Materials and Methods: A prospective study was done in patients with unilateral,idiopathic full thickness MH. Standard surgery with vitrectomy, internal limiting membrane peeling and gas tamponade was done. Snellen and logMAR visual acuity, mfERG, microperimetry and optical coherence tomography were done pre and postoperatively. Results: Twenty six patients with unilateral macular hole and twenty five age matched controls were included. The mean age of patients was 59.92±9.39 years (range: 40 to 74 years). All the holes were closed after surgery (two required second surgery). The mean visual acuity improved from 0.77±0.34 logMAR to 0.43±0.36 (p =0.03). The mfERG amplitudes differed ring wise, but the average amplitude changed from 26.31±8.82 to 20.52±7.11 (p =0.03). The mean retinal sensitivity changed from 12.98±2.59 to 13.42±2.53 (p =0.11). There was significant correlation between visual acuity and mfERG amplitudes and retinal sensitivity. Regression equations to predict visual outcome could be derived. Conclusions: In MH, mfERG and microperimetry show reduced responses, delay in recovery of function. They show a strong correlation with visual acuity. It is possible to predict vision after surgery with the help of mfERG and MP. Improved ability to predict visual outcome can increase the utility of anatomic success predictors.

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Untitled

Cited by 21 publications

References 12 publications

Changes in first- and second-order multifocal electroretinography in idiopathic macular hole and their correlations with macular hole diameter and visual acuity

Changes in first- and second-order multifocal electroretinography in idiopathic macular hole and their correlations with macular hole diameter and visual acuity

Inverted Internal Limiting Membrane Flap Technique for Repair of Large Macular Holes

Macular function assessment by multifocal electroretinogram and microperimetry in macular hole and correlation with visual acuity

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