Untitled

Ha, Suk-Woo; Kirch, M; Birchler, F; Eckert, K.-L.; Mayer, Joerg; Wintermantel, E.; Sittig, C; Pfund-Klingenfuss, I; Textor, Marcus; Spencer, N. D.; Guecheva, M.; Vonmont, Heinz

doi:10.1023/a:1018535923173

Cited by 123 publications

(60 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[49] Indeed, control films that were not pre-treated with NaOH showed no apatite deposition even after 30 days in 1.5 SBF, as also observed by others. [36,50] Therefore, our observations are in agreement with various groups, who have demonstrated the need of NaOH pretreatment for apatite formation. Jonasova et al (2002), [46] e.g., used SBF to form an apatite layer on the surface of NaOH-treated titanium.…”

Section: Discussionsupporting

confidence: 92%

Apatite Deposition on NaOH‐Treated PEEK and UHMWPE Films for Sclera Materials in Artificial Cornea Implants

et al. 2010

View full text Add to dashboard Cite

Cornea implants consist of a clear optic portion with a surrounding ring known as the skirt, which needs to integrate with the sclera. However, currently used skirt materials lead to poor tissue integration. Improvements in this respect may be achieved by using a bioactive skirt material that adapts to the metabolic activity of the cornea. Polyether etherketone (PEEK) and ultra‐high molecular weight polyethylene (UHMWPE) might provide interesting alternatives, if they can be rendered bioactive. We, therefore, investigated the potential of surface‐modifying PEEK and UHMWPE films through the use of a two‐step treatment. This process involved a suitable chemical surface modification (via immersion in NaOH), with subsequent formation of apatite layers on the polymers' surfaces through exposure to supersaturated simulated body fluid (1.5 SBF). In the present work the effect of 5 and 10 M NaOH on formation of the apatite layer has been investigated with regard to wettability and topography features. In addition, the chemical stability of the apatite layer formed has been analyzed. Our data demonstrate that with an increase in NaOH concentration the wettability of the polymer increased, whilst some changes to the polymer film topography (increase/decrease in roughness) were observed. Most beneficially, the apatite layer that subsequently was grown on pre‐treated PEEK and UHMWPE films through immersion in 1.5 SBF contained phosphate and carbonate ions, in similar ratios to those found in the apatite in dentine, thus, promising good in vivo bioactivity of these polymer films—a necessity if they are to be integrated into artificial cornea.

show abstract

Section: Discussionsupporting

confidence: 92%

Apatite Deposition on NaOH‐Treated PEEK and UHMWPE Films for Sclera Materials in Artificial Cornea Implants

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Surface modifications such as plasma or chemical etching [10–12], addition of bioactive coatings [13, 14], and PEEK composites have performed well in vitro and in vivo [15], yet their clinical success may be limited due to their potential instability and delamination in physiological or surgical environments [16, 17]. Introducing bulk porosity throughout PEEK implants via powder sintering (or compression molding) aims to increase implant fixation by encouraging the migration and proliferation of various cell types to enhance vascular and bone tissue ingrowth [3, 18].…”

Section: Introductionmentioning

confidence: 99%

High-strength, surface-porous polyether-ether-ketone for load-bearing orthopedic implants

Evans

Torstrick

Lee³

et al. 2015

Acta Biomaterialia

177

140

View full text Add to dashboard Cite

Despite its widespread clinical use in load-bearing orthopaedic implants, polyether-ether-ketone (PEEK) is often associated with poor osseointegration. In this study, a surface porous PEEK material (PEEK-SP) was created using a melt extrusion technique. The porous layer thickness was 399.6±63.3 µm and possessed a mean pore size of 279.9±31.6 µm, strut spacing of 186.8±55.5 µm, porosity of 67.3±3.1%, and interconnectivity of 99.9±0.1%. Monotonic tensile tests showed that PEEK-SP preserved 73.9% of the strength (71.06±2.17 MPa) and 73.4% of the elastic modulus (2.45±0.31 GPa) of as-received, injection molded PEEK. PEEK-SP further demonstrated a fatigue strength of 60.0 MPa at one million cycles, preserving 73.4% of the fatigue resistance of injection molded PEEK. Interfacial shear testing showed the pore layer shear strength to be 23.96±2.26 MPa. An osseointegration model in the rat revealed substantial bone formation within the pore layer at 6 and 12 weeks via µCT and histological evaluation. Ingrown bone was more closely apposed to the pore wall and fibrous tissue growth was reduced in PEEK-SP when compared to non-porous PEEK controls. These results indicate that PEEK-SP could provide improved osseointegration while maintaining the structural integrity necessary for load-bearing orthopaedic applications.

show abstract

“…The contact angle of PEEK substrate (=88.8°) is consistent to the value reported elsewhere (=85°). 18) As the AFM results indicate, no significant difference in surface roughness was observed, regardless of the changes in the distance of the lamp to the PEEK substrate and irradiation time. On the basis of the present data, the surface modification conditions can be optimized by the selection of irradiation distance and time being 1 mm and 120 min, respectively.…”

Section: ¹1mentioning

confidence: 76%

Rapid formation of hydroxyapatite layer on polyetheretherketone by vacuum ultraviolet irradiation and microwave heating techniques

Suzuki

Umeda

Sumi

et al. 2016

J. Ceram. Soc. Japan

View full text Add to dashboard Cite

Rapid formation of hydroxyapatite [Ca 10 (PO 4 ) 6 (OH) 2 ; HAp] layer on the polyetheretherketone (PEEK) substrate was examined by the combined techniques of vacuum ultraviolet (VUV) irradiation and microwave heating. The surface properties of PEEK substrate were modified by the formation of carboxyl group due to the VUV irradiation at room temperature in air, whereas the formation of HAp layer was encouraged by the microwave heating of surface-modified PEEK substrate in the HAp-dissolved solution. The optimization of the fabrication conditions was conducted by checking (i) the distance of VUV lamp to PEEK substrate (112 mm) and VUV irradiation time (0120 min) for the surface modification of PEEK substrate, and (ii) the microwave heating temperatures (100 and 140°C) for the rapid formation of HAp layer on the PEEK substrate. When the PEEK substrate was surface-modified by the VUV irradiation for 120 min with the distance of VUV lamp to PEEK substrate kept being 1 mm, and then was microwave-heated in the HAp-dissolved solution at 140°C for 10 min, the thickness of the HAp layer on the PEEK substrate attained approximately 10¯m.

show abstract

Untitled

Cited by 123 publications

References 9 publications

Apatite Deposition on NaOH‐Treated PEEK and UHMWPE Films for Sclera Materials in Artificial Cornea Implants

Apatite Deposition on NaOH‐Treated PEEK and UHMWPE Films for Sclera Materials in Artificial Cornea Implants

High-strength, surface-porous polyether-ether-ketone for load-bearing orthopedic implants

Rapid formation of hydroxyapatite layer on polyetheretherketone by vacuum ultraviolet irradiation and microwave heating techniques

Contact Info

Product

Resources

About