No Association between Catalase Gene Polymorphism and Gastric Carcinoma and Hepatocellular Carcinoma in Koreans

Abstract

To address the possible contribution of oxidative stresses to the pathogenesis of gastric and hepatocellular carcinomas, the associations between the catalase gene polymorphism and GC and HCC susceptibilities were studied. As a result, the catalase gene polymorphism was found not to be determinant of GC and HCC susceptibilities. Further studies are required on various other oxidative stress related genes to elucidate the mechanisms of GC and HCC.

Association Between Catalase Gene Polymorphisms and Risk of Chronic Hepatitis B, Hepatitis B Virus-Related Liver Cirrhosis and Hepatocellular Carcinoma in Guangxi Population

“… 25 , 26 The first association between CAT polymorphisms and HCC risk was reported by Lee et al in 2002. 27 They included 106 patients with HCC, but found no associations between CAT gene rs7943316 polymorphism and HCC risk. In 2009, Nahon et al 25 assessed 190 HCC patients with alcoholic cirrhosis but also found no associations between CAT gene rs1001179 polymorphisms and HCC risk.…”

“… 25 Another study, assessing 106 Korean patients with HCC, also found nonsignificant association between CAT gene polymorphisms and HCC risk. 27 However, the sample sizes of these 3 studies were very limited, and only 1 SNP (rs1001179 or rs7943316) of the CAT gene was investigated. In addition, the genotype distributions of the CAT polymorphisms vary with ethnicity, and until now no study has been carried out on the association between the CAT polymorphisms and HCC risk in the Chinese population.…”

Two common functional catalase gene polymorphisms (rs1001179 and rs794316) and cancer susceptibility: evidence from 14,942 cancer cases and 43,285 controls

“…The eligible studies presented data for several different cancer types, including prostate cancer, hepatocellular carcinoma, breast cancer, and colorectal cancer. Among these studies, 10 were based on Asian populations [ 9 , 13 , 15 – 17 , 20 – 22 ], 20 on Caucasian populations [ 7 , 10 , 11 , 14 , 18 , 23 – 33 ], 1 on an African population [ 14 ], and 6 on mixed-ethnicity populations [ 12 , 19 , 31 , 34 – 36 ]. Furthermore, in 3 studies, the genotype distributions of the control groups departed from Hardy-Weinberg equilibrium (HWE) [ 7 , 10 , 20 ].…”

“…A previous meta-analysis including 9,777 cancer patients and 12,223 controls showed significant association between rs1001179 polymorphism and cancer risk in the recessive model [ 39 ]. Compared with that meta-analysis, our meta-analysis included 11 new independent studies of hepatocellular carcinoma [ 16 , 17 , 22 , 34 ], chronic myeloid leukemia [ 24 ], laryngeal cancer [ 25 ], colorectal cancer [ 20 ], and oral cavity cancer [ 9 ]. Different from the previous result, we observed an association between the rs1001179 polymorphism and an increased cancer risk in the homozygote model.…”

Association of Antioxidative Enzymes Polymorphisms with Efficacy of Platin and Fluorouracil-Based Adjuvant Therapy in Gastric Cancer

“…Two common CAT SNPs, rs1001179 and rs794316, were found to be associated with prostate cancer risk and survival [42,43]. So far, there is no riskrelated CAT polymorphisms identified in gastric cancer [44,45]. Rs769218, an intronic SNP in CAT, was found associated with breast overall survival in patients who did not received radiotherapy [46].…”