No Association Between Helicobacter pylori Infection or CagA-bearing Strains and Glaucoma

Kurtz, Shimon; Regenbogen, Michael; Goldiner, Ilana; Horowitz, Noya; Moshkowitz, Menachem

doi:10.1097/ijg.0b013e31815a34ac

Cited by 48 publications

(41 citation statements)

References 22 publications

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“…In 2 subsequent studies, we reported: (1) a beneficial effect of H. pylori eradication on glaucoma progression, suggesting a possible causal link between the bacterium and glaucoma [5] , and (2) increased H. pylori-specific IgG antibody concentration in the aqueous humor of POAG patients, the concentration of which correlated with the degree of vertical cupping, possibly indicating the severity of glaucomatous damage [6] . Reports from other ethnic populations have also shown a relationship between glaucoma and H. pylori infection [7,8] , although this has not been confirmed by all the relevant studies published so far [9,10] , and thus this association may only apply to a limited subpopulation of glaucoma patients. Similar observations have been made in Korea, China, India, Turkey and Iran [8,11] .…”

Section: Introductionmentioning

confidence: 77%

Histological Presence of <i>Helicobacter pylori</i> Bacteria in the Trabeculum and Iris of Patients with Primary Open-Angle Glaucoma

et al. 2011

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Purpose: To investigate the role of Helicobacter pylori in primary open-angle glaucoma (POAG) pathophysiology by detecting its presence in eye biopsies of POAG patients during trabeculectomy. Patients and Methods: Fifty-one consecutive patients who underwent trabeculectomy for POAG not responsive to antiglaucoma therapy, and 35 consecutive anemic controls were examined for H. pylori presence mainly by gastric mucosa histology. In POAG patients, eye biopsies were also obtained and stained for H. pylori presence in situ. Results: Forty-three of 51 (84.3%) POAG patients and 17 of 35 (48.6%) controls were tested H. pylori positive (p = 0.0004). In 5 H. pylori-positive POAG patients, H. pylori bacteria were identified in the trabeculum and iris specimens. Conclusion: For the first time, H. pylori bacteria have been detected histologically in eye biopsies of POAG patients.

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Section: Introductionmentioning

confidence: 77%

Histological Presence of <i>Helicobacter pylori</i> Bacteria in the Trabeculum and Iris of Patients with Primary Open-Angle Glaucoma

et al. 2011

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“…In another study using the same method, Galloway et al found no relationship between H. pylori infection positivity and glaucoma (24) . Similarly, no relationship was found between glaucoma and H. pylori infection positivity in a study by Kurtz et al, in which serology and cytotoxin-associated geneA (CagA) seropositivity were evaluated (25) . Handa et al reported that the CagA gene may be associated with apoptosis, irregular gastric cell activity, and carcinogenesis (26) .…”

Section: Discussionmentioning

confidence: 99%

Investigation of the association between glaucoma andHelicobacter pyloriinfection using the¹⁴C-urea breath test

Tuzcu¹,

Aydogan²,

Motor³

et al. 2015

Arquivos Brasileiros De Oftalmologia

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Purpose: To investigate the association between glaucoma and Helicobacter pylori infection by evaluating for the presence of H. pylori infection in patients with glaucoma using the 14 C-urea breath test (14C-UBT). Methods: Using 14C-UBT, H. pylori infection positivity was compared between a group of patients with primary open-angle glaucoma and a control group with normal intraocular pressure and a normal optic disc or normal perimetry. Results: The 14C-UBT was positive in 18 (51.42%) out of 35 patients in the glaucoma group and in 15 (42.85%) out of 35 patients in the control group. H. pylori infection positivity rates were similar between the glaucoma and control groups (p>0.05). Conclusion: According to the 14C-UBT, there is no association between primary open-angle glaucoma and H. pylori infection.

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“…Neither H. pylori infection nor seropositivity for virulent CagA-bearing H. pylori strains has significant association with the occurrence of glaucoma of any type (Kurtz et al, 2008). Eye color is one of the major racial and diagnostic features in anthropological studies and it is used to characterize differences between populations where certain authors have shown some associations between eye color *Corresponding author.…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori and eye diseases in an Iranian hospital

Yaghoobi¹,

Rezvani²,

Heidari³

2013

Afr. J. Microbiol. Res.

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There is evidence of Helicobacter pylori infection that induces eye diseases. This study was done to find if there is any association between H. Pylori and ocular diseases, and if there is any difference in color of eye among them. Of all the 35 patients tested for biopsy with positive H. pylori, 23 (65.7%) were females and 12 (34.3%), males. The mean age of patients was 39.65±18.55 years. 20 (57.1%) patients were below 40 years old; 8 (22.9%) patients, 40 to 60 years and only 7 patients were more than 60 years old. Most of the patients were 20 years old and had no ophthalmic or systemic diseases in juvenile age group; most of them with the best correct vision were within normal measure, except the old patients who had normal tension glaucoma and two cataract cases. Brown eyes were the commonest but blue color was the least without any risk of ocular diseases or H. Pylori associated with more prevalent brown iris color in study group. Ophthalmic extragastric diseases do not show any association between eye diseases and H. pylori infection in juvenile age groups. Pesudoexfolitive glaucoma and two cases of cataract were among the old age related diseases which may be due to the late appearance of H. pylori effect. Best visual acuity, cup/disc character and brown color were the most associated finding.

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No Association Between Helicobacter pylori Infection or CagA-bearing Strains and Glaucoma

Abstract: Neither H. pylori infection nor seropositivity for virulent CagA-bearing H. pylori strains have significant association with the occurrence of glaucoma of any type.

Cited by 48 publications

References 22 publications

Histological Presence of <i>Helicobacter pylori</i> Bacteria in the Trabeculum and Iris of Patients with Primary Open-Angle Glaucoma

Histological Presence of <i>Helicobacter pylori</i> Bacteria in the Trabeculum and Iris of Patients with Primary Open-Angle Glaucoma

Investigation of the association between glaucoma andHelicobacter pyloriinfection using the¹⁴C-urea breath test

Helicobacter pylori and eye diseases in an Iranian hospital

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No Association Between Helicobacter pylori Infection or CagA-bearing Strains and Glaucoma

Abstract: Neither H. pylori infection nor seropositivity for virulent CagA-bearing H. pylori strains have significant association with the occurrence of glaucoma of any type.

Cited by 48 publications

References 22 publications

Histological Presence of <i>Helicobacter pylori</i> Bacteria in the Trabeculum and Iris of Patients with Primary Open-Angle Glaucoma

Histological Presence of <i>Helicobacter pylori</i> Bacteria in the Trabeculum and Iris of Patients with Primary Open-Angle Glaucoma

Investigation of the association between glaucoma andHelicobacter pyloriinfection using the14C-urea breath test

Helicobacter pylori and eye diseases in an Iranian hospital

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Product

Resources

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Investigation of the association between glaucoma andHelicobacter pyloriinfection using the¹⁴C-urea breath test