No association between IL-1RN VNTR and the risk of duodenal ulcer: A meta-analysis

ObjectiveTo perform a meta-analysis to evaluate studies investigating the association between ATG16L1 gene polymorphism and Crohn’s disease.MethodsPubMed, Embase and Web of Science databases were searched for all studies focusing on the association of ATG16L1 and Crohn’s disease. Combined odds ratios with 95% confidence intervals were calculated for four genetic models (allelic model: G allele versus A allele; additive model: GG versus AA; dominant model: GA + GG versus AA; recessive model: GG versus GA + AA) using either a random effects or fixed effects model.ResultsA total of 47 case–control studies involving 18 638 cases and 30 181 controls were included in the final meta-analysis. There was a significant association between ATG16L1 and Crohn’s disease for all four genetic models. Significant associations were also shown in subgroup analyses when stratified by study design (population- or hospital-based).ConclusionIn this meta-analysis, the ATG16L1 genotype was significantly associated with the risk of developing Crohn’s disease.

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“…In addition, a quality assessment was performed on all included studies using the Newcastle–Ottawa Scale (NOS) as described elsewhere. 8 …”

Section: Methodsmentioning

confidence: 99%

Association between ATG16L1 gene polymorphism and the risk of Crohn’s disease

Zhang

Yang

et al. 2016

J Int Med Res

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“…Quality score assessment was performed using NewcastleOttawa Scale (NOS) as previous described [20]. Briefly, two authors (Yan MS and Liang GY) of this article independently assessed the qualities based on and scored the studies from 0 to 9 points.…”

Section: Quality Score Assessmentmentioning

confidence: 99%

Association of insulin gene variable number of tandem repeats regulatory polymorphism with polycystic ovary syndrome

et al. 2014

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“…pylori related-diseases has been extensively investigated [21–23]. One meta-analysis reported that the short genotype of IL-1RN VNTR significantly increases the risk of gastric cancer [24]; another paper found that IL-1RN VNTR has no association with duodenal ulcer [25]. A number of studies performed on H .…”

Section: Introductionmentioning

confidence: 99%

Association of the IL-1RN variable number of tandem repeat polymorphism and Helicobacter pylori infection: A meta-analysis

Zhang¹,

Sun²,

Wang³

et al. 2017

PLoS ONE

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The aim of this study was to clarify the association of IL-1RN variable number of tandem repeat (VNTR) polymorphism and H. pylori infection. We performed a meta-analysis of studies retrieved by systematic searches of Pubmed, Embase and the Cochrane Library. Data were analyzed with STATA 13.1 using pooled odds ratios (ORs) with 95% confidence intervals (CIs). A total of 18 studies were included in our meta-analysis, and IL-1RN VNTR was found to be significantly associated with H. pylori infection in the comparisons of 22+2L vs. LL (OR = 1.17, 95% CI = 1.02–1.33) and 2 allele vs. L allele (OR = 1.18, 95% CI = 1.00–1.40). Stratified analyses on study designs and ethnicities were also conducted. IL-1RN VNTR was positively correlated with H. pylori infection in Asian subgroup and Hospital-Based subgroup (i.e., study samples obtained from hospital inpatients). In conclusion, our study demonstrated that IL-1RN VNTR polymorphism might increase the risk of H. pylori infection, especially in Asians.

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No association between IL-1RN VNTR and the risk of duodenal ulcer: A meta-analysis

Cited by 4 publications

References 56 publications

Association between ATG16L1 gene polymorphism and the risk of Crohn’s disease

Association between ATG16L1 gene polymorphism and the risk of Crohn’s disease

Association of insulin gene variable number of tandem repeats regulatory polymorphism with polycystic ovary syndrome

Association of the IL-1RN variable number of tandem repeat polymorphism and Helicobacter pylori infection: A meta-analysis

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