2005
DOI: 10.1002/cbf.1274
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No association between methylenetetrahydrofolate reductase C677T polymorphism and breast cancer

Abstract: Methylenetetrahydrofolate reductase (MTHFR) is an enzyme (EC 1.5.1.20), that reduces 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a carbon donor for the homocysteine to methionine conversion. MTHFR is a key enzyme that regulates folate metabolism which has an important role in DNA synthesis, DNA repair and methylation. The association between MTHFR C677T polymorphism and breast cancer has been investigated in several previous studies. Some researchers have shown an association between C677T poly… Show more

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Cited by 37 publications
(34 citation statements)
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“…13,14,[23][24][25][26][27] Many meta-analysis studies have also supported this conclusion. 11,15 On the other hand, no association between MTHFR genotypes and the risk of breast cancer was noted in other studies [28][29][30][31][32] and two meta-analyses. 12,33 The reasons for these inconsistent results are not clear, but clearly variation with ethnicity and environment could contribute to differences in influence on the development of breast cancer.…”
Section: Discussionmentioning
confidence: 89%
“…13,14,[23][24][25][26][27] Many meta-analysis studies have also supported this conclusion. 11,15 On the other hand, no association between MTHFR genotypes and the risk of breast cancer was noted in other studies [28][29][30][31][32] and two meta-analyses. 12,33 The reasons for these inconsistent results are not clear, but clearly variation with ethnicity and environment could contribute to differences in influence on the development of breast cancer.…”
Section: Discussionmentioning
confidence: 89%
“…There are some studies in favor of this argument (43), most of them in people from Turkey and oriental countries (44,45). This hypothesis is refuted by different authors in different populations (46,47). Moreover, there are studies that support a possible benefit of this polymorphism in the prevention of breast cancer (48).…”
Section: Discussionmentioning
confidence: 99%
“…A meta-analysis including data from this study and 21 previously published studies [5][6][7][8][9][10][11][12][13][14][27][28][29][30][31][32][33] showed no association between variant vs. common homozygote genotypes for MTHFR A222V and breast cancer risk [summary OR (95% CI) 5 0.99 (0.86-1.15), based on 8,330 cases and 10,825 controls]. Similarly, a meta-analysis including data from our study and 12 previously published studies 5,6,8,9,13,14,27,28 showed no evidence for an overall association for MTHFR E429A (summary OR 5 1.00; 95% CI 0.85-1.17 based on 6,521 cases and 8,515 controls; Table III).…”
Section: Meta-analysesmentioning
confidence: 99%