No association between periodontitis, preterm birth, or intrauterine growth restriction: experimental study in Wistar rats

Fogacci, Mariana Fampa; Barbirato, Davi da Silva; Amaral, Cristine da Silva Furtado; Silva, Priscilla Gonçalves da; Coelho, Mariana de Oliveira; Bertozi, Giuliana; Carvalho, Denise P.; Leão, Anna Thereza Thomé

doi:10.1016/j.ajog.2015.12.008

Cited by 14 publications

(13 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…So far, most experimental animal models showed APO caused by periodontal diseases; however, Fogacci et al . found no association between periodontitis and PTB and LBW in Wister rats …”

Section: Experimental Animal Modelsmentioning

confidence: 87%

Periodontal diseases and adverse pregnancy outcomes

Komine‐Aizawa

Aizawa

Hayakawa

2018

J of Obstet and Gynaecol

111

View full text Add to dashboard Cite

From last decade of the 20th century, numerous epidemiological studies and intervention trials have attempted to prove the relationships between maternal periodontal diseases and adverse pregnancy outcomes (APO). Periodontal diseases are considered a risk factor for APO, including preterm birth, fetal growth restriction, low birthweight, pre-eclampsia and gestational diabetes. However, the efficacy of periodontal treatment during pregnancy is controversial. Two pathogenic mechanisms might explain the potential effect of periodontal diseases on pregnancy outcomes. First, periodontal bacteria originating in the gingival biofilm directly affect the feto-placental unit subsequent to bacteremia. Second, inflammatory mediators secreted by the subgingival inflammatory site are carried to the feto-placental unit, where they then cause an inflammatory response. To elucidate these mechanisms, many researchers have been investigating the use of experimental animal models and in vitro models. In the present review, we summarize the current literature on the relationship between periodontal diseases and APO from epidemiological studies, animal models studies and in vitro studies, and speculate on the possible mechanism of periodontal diseases affecting pregnancy outcomes.

show abstract

“…So far, most experimental animal models showed APO caused by periodontal diseases; however, Fogacci et al . found no association between periodontitis and PTB and LBW in Wister rats …”

Section: Experimental Animal Modelsmentioning

confidence: 87%

Periodontal diseases and adverse pregnancy outcomes

Komine‐Aizawa

Aizawa

Hayakawa

2018

J of Obstet and Gynaecol

111

View full text Add to dashboard Cite

show abstract

“…To the present moment, no experimental study was conducted to investigate the mechanism-based reasoning linking periodontitis and infertility. The two experimental studies conducted that found such association had infertility as a secondary outcome [16,17]. One of them [17], in the discussion section, exposes two possible biological explanations.…”

Section: Biological Plausibility Of the Possible Association Between mentioning

confidence: 99%

“…The two experimental studies conducted that found such association had infertility as a secondary outcome [16,17]. One of them [17], in the discussion section, exposes two possible biological explanations. As periodontitis causes a systemic inflammation (pointed out in the study results section by the systemic rise of pro-inflammatory cytokines and decrease of anti-inflammatory cytokines) that could interfere with fertility, possibly due to: a) preventing ovulation; b) preventing implantation of the embryo or not sustaining its implantation.…”

Section: Biological Plausibility Of the Possible Association Between mentioning

confidence: 99%

“…Two experimental studies pointed out the infertility problem as secondary outcomes in rodents challenged with periodontitis [16,17]. Despite the different models of experimentally induced periodontitis, both studies found significant lower fecundity rates in the periodontitis groups.…”

Section: Epidemiological Evidencesmentioning

confidence: 99%

“…to be fully read ( Figure 1). There were two epidemiological studies [10,13], one inquiry [14], one editorial [15] and two experimental studies [16,17]. Studies main characteristics are presented in Table 1.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Periodontitis and Infertility: An Evidence-Based Review

Fogacci¹,

Barbirato²,

Rodrigues³

et al. 2016

Glob J Fertil Res

View full text Add to dashboard Cite

The inclusion criteria were epidemiological or clinical studies, experimental / animal model studies, inquiries or editorials on the theme periodontitis and infertility, published until May 2016. Letters to the editor, narrative reviews, and articles bringing out other endocrine or reproductive diseases that were not about infertility were not included. The first selection was conducted after the title and abstract reading, establishing which publications fit inclusion criteria, and could be chosen to take part in the review. References were selected for full-text reading when it was not possible to determine if the inclusion criteria were attended by their title and abstract. Additionally, the reference lists of the publications identified were searched for possible studies that did not come up in the initial search. After the selection, all papers were read in full and then grouped by study design. Main methods, results and conclusions were described for each article. Also, the strength of the evidence was analyzed, according to the Oxford Centre for Evidence-Based Medicine [12], key findings highlighted and limitations listed. Results The initial search retrieved 47 papers, from which 40 were excluded, and one was duplicated. Thus, six publications remained Methods This evidence-based review was conducted to gather results from the majority of the studies published evaluating the subject of periodontitis and infertility issue. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement [11], was consulted for reporting this review.

show abstract

Periodontal and caries status in unexplained female infertility: A case–control study

Telatar

Gürlek

Telatar³

2021

Journal of Periodontology

View full text Add to dashboard Cite

Background: The aim of this study was to investigate the possible association between maternal periodontal disease and dental caries that affect oral health and unexplained infertility. Methods: This cross-sectional case-control study included 50 fertile women and 50 women with unexplained infertility aged 21 to 39 years. Dental and periodontal parameters were examined to evaluate the oral health of the participants. According to the new periodontal disease classification, periodontitis severity was determined. Results: In infertile women, the number of advanced caries lesions, the percentage of bleeding on probing (BOP), gingival index (GI), probing depth (PD), and clinical attachment level (CAL) were higher (P < 0.05). The DMFT and mean plaque index (PI) were not statistically different between the two groups. The PISA and PESA values were higher in women with unexplained infertility than in fertile women (P = 0.005 and P = 0.002, respectively). In multivariate analysis showed that association of DMFT and BOP variables with periodontitis was found to be significant for all women included in the study and for infertile women only (P = 0.000 and P = 0.012 for DMFT, respectively; P = 0.000 and P = 0.016 for BOP, respectively). Conclusion: The chronic inflammatory environment caused by periodontitis and advanced carious lesions in women with unexplained infertility should be of great concern as it may have a role in the etiology of infertility.

show abstract

No association between periodontitis, preterm birth, or intrauterine growth restriction: experimental study in Wistar rats

Cited by 14 publications

References 50 publications

Periodontal diseases and adverse pregnancy outcomes

Periodontal diseases and adverse pregnancy outcomes

Periodontitis and Infertility: An Evidence-Based Review

Periodontal and caries status in unexplained female infertility: A case–control study

Contact Info

Product

Resources

About