No association between severe constipation with related drug treatment in pregnant women and congenital abnormalities in their offspring: A population‐based case‐control study

Ács, Nándor; Bánhidy, Ferenc; Puhó, Erzsébet; Czeizel, Andr̀ew E.

doi:10.1111/j.1741-4520.2009.00252.x

Cited by 14 publications

(6 citation statements)

References 19 publications

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“…Although some researches of Senna have found that it is effective in a short-term usage of constipation treatment in pregnancy [258][259][260] and does not have the teratogenic potential [261], intake of Senna during the pregnancy is allowed only in some countries like the USA.…”

Section: Sennamentioning

confidence: 99%

A Review of Recent Studies on the Antioxidant and Anti-Infectious Properties of Senna Plants

Alshehri

Quispe

Herrera‐Bravo

et al. 2022

Oxidative Medicine and Cellular Longevity

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The use of phytochemicals is gaining interest for the treatment of metabolic syndromes over the synthetic formulation of drugs. Senna is evolving as one of the important plants which have been vastly studied for its beneficial effects. Various parts of Senna species including the root, stem, leaves, and flower are found rich in numerous phytochemicals. In vitro, in vivo, and clinical experiments established that extracts from Senna plants have diverse beneficial effects by acting as a strong antioxidant and antimicrobial agent. In this review, Senna genus is comprehensively discussed in terms of its botanical characteristics, traditional use, geographic presence, and phytochemical profile. The bioactive compound richness contributes to the biological activity of Senna plant extracts. The review emphasizes on the in vivo and in vitro antioxidant and anti-infectious properties of the Senna plant. Preclinical studies confirmed the beneficial effects of the Senna plant extracts and its bioactive components in regard to the health-promoting activities. The safety, side effects, and therapeutic limitations of the Senna plant are also discussed in this review. Additional research is necessary to utilize the phenolic compounds towards its use as an alternative to pharmacological treatments and even as an ingredient in functional foods.

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Section: Sennamentioning

confidence: 99%

A Review of Recent Studies on the Antioxidant and Anti-Infectious Properties of Senna Plants

Alshehri

Quispe

Herrera‐Bravo

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…No study has specifically addressed the teratogenic effects of cathartics; however, no congenital anomalies were seen among 22843 pregnant women treated with laxatives[95]. The FDA reclassified cathartics and laxative agents from category B to category X. Cathartics are associated with a risk of dehydration and electrolyte imbalance.…”

Section: Medical Treatmentmentioning

confidence: 99%

Treatment of pregnant women with a diagnosis of inflammatory bowel disease

Poturoğlu¹,

Örmeci²,

Duman³

2016

WJGPT

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The frequency of diagnosis of inflammatory bowel disease (IBD) has increased in younger populations. For this reason, pregnancy in patients with IBD is a topic of interest, warranting additional focus on disease management during this period. The main objective of this article is to summarize the latest findings and guidelines on the management of potential problems from pregnancy to the breastfeeding stage. Fertility is decreased in patients with active IBD. Disease remission prior to conception will likely decrease the rate of pregnancy-related complications. Most of the drugs used for IBD treatment are safe during both pregnancy and breastfeeding. Two exceptions are methotrexate and thalidomide, which are contraindicated in pregnancy. Anti-tumor necrosis factor agents are not advised during the third trimester as they exhibit increased transplacental transmission and potentially cause immunosuppression in the fetus. Radiological and endoscopic examinations and surgical interventions should be performed only when absolutely necessary. Surgery increases the fetal mortality rate. The delivery method should be determined with consideration of the disease site and presence of progression or flare up. Treatment planning should be a collaborative effort among the gastroenterologist, obstetrician, colorectal surgeon and patient.

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“…In Japan, magnesium oxide (MgO) is used as an osmotic laxative ( Morishita et al, 2021 ). The second-line therapy is based on stimulant laxatives, mainly senna ( Ford, 2008 ; Ács et al, 2010 ). Stimulant laxatives include sennosides and senna glycosides (SG).…”

Section: Introductionmentioning

confidence: 99%

No association between major congenital malformations and exposure to Kampo medicines containing rhubarb rhizome: A Japanese database study

Suzuki

Obara²,

Ishikawa³

et al. 2023

Front. Pharmacol.

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Traditional Japanese (Kampo) medicines containing rhubarb rhizome are prescribed for constipation during pregnancy; however, detailed safety information of their use for pregnant women is lacking. The aim of current study was to clarify the association between prescription Kampo-containing rhubarb rhizome (KRR) in the first trimester of pregnancy and congenital malformations in newborns. Using a large Japanese health insurance claims database, we included pregnant women who enrolled the same health insurance society from 3 months before pregnancy to the delivery date, who gave birth between 2010 and 2019, and those with data related to their infants. Pregnant women who were prescribed magnesium oxide (MgO), commonly used for constipation, during the first trimester of pregnancy and their infants were extracted as controls. Associations between KRR prescribed in the first pregnancy trimester and major congenital malformations (MCM) in the infants were examined using multivariate logistic regression analysis. Of 75,398 infants, 4,607 (6.1%) were diagnosed with MCMs within the first year after birth. Furthermore, 9,852 infants were born to women prescribed MgO, among whom 680 (6.9%) had MCMs; 450 infants were born to women prescribed KRR, among whom 28 (6.2%) had MCMs. Multivariate logistic regression analysis identified no difference in MCM risk between the two types of prescriptions [crude odds ratio (OR) 0.895, 95% confidence interval (CI) 0.606–1.322, adjusted OR 0.889, 95% CI 0.599–1.320]. In conclusion, the risk of MCMs did not differ between those prescribed KRR or MgO in the first trimester of pregnancy.

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No association between severe constipation with related drug treatment in pregnant women and congenital abnormalities in their offspring: A population‐based case‐control study

Cited by 14 publications

References 19 publications

A Review of Recent Studies on the Antioxidant and Anti-Infectious Properties of Senna Plants

A Review of Recent Studies on the Antioxidant and Anti-Infectious Properties of Senna Plants

Treatment of pregnant women with a diagnosis of inflammatory bowel disease

No association between major congenital malformations and exposure to Kampo medicines containing rhubarb rhizome: A Japanese database study

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