No association of<i>TP</i>53 codon 72 SNP with male infertility: a study in a Chinese population and a meta-analysis

Chan, Ying; Jiang, Hongguo; Ma, Lan; Chen, Jinbao; Li, Dongya; Meng, Yushi; Luo, Ying; Tang, Wenru

doi:10.3109/19396368.2015.1017667

Cited by 5 publications

(5 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results were in partial agreement with Huang and colleagues, Lu and colleagues and Ying and colleagues but different from Mashayekhi and Hadiyan and Jin and co-worker who suggested that Arg appears to increase the risk of developing idiopathic male infertility in Iranian and southeast Chinese men (9, 12, 25-27). Only one case-control study by Haung and colleagues has investigated the association of MDM2 SNP 309 T>G with the risk of male infertility but our results do not support their research who reported a statistical association between MDM2 SNP 309 T>G with idiopathic male infertility (25).…”

Section: Discussionsupporting

confidence: 73%

“…Recently, Ying Chan and co-worker performed a meta-analysis based on the data from four currently available studies (9, 25-27) to clarify the association of p53 R72P with male infertility. They also reported no association between rs1042522 and idiopathic male infertility (12).…”

Section: Discussionmentioning

confidence: 99%

“…Numerous attempts have been made to identify single nucleotide polymorphisms (SNPs) affecting male infertility, such as TP53 and MDM2 , but the conclusions of previous studies were inconsistent. Therefore more study is required in order to clarify their association (10-12). Researchers have reported numerous SNPs in the p53 pathway and some of them may change the function of the TP53 protein.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The frequency of TP53 R72P and MDM2 309T>G polymorphisms in Iranian infertile men with spermatogenetic failure: A case-control study

Abadi

Bami

Golzadeh

et al. 2018

IJRM

View full text Add to dashboard Cite

Background:Tumor protein p53 (TP53) is a tumor suppressor transcriptional regulator protein which plays a critical role in the spermatogenesis. One of the most important regulators of p53 is Murine double minute 2 (MDM2), which acts as a negative regulator of the p53 pathway. Based on the key role of p53 and MDM2 in germ cell apoptosis, polymorphisms that cause a change in their function might affect germ cell apoptosis and the risk of male infertility.Objective:This study was designed to examine associations of TP53 72 Arg>Pro (rs1042522), and MDM2 309 T>G (rs937283) polymorphisms with spermatogenetic failure in Iranian population.Materials and Methods:A case-control study was conducted with 150 nonobstructive azoospermia or severe oligozoospermia and 150 fertile controls. The two polymorphisms, 72 Arg>Pro in TP53 and 309 T>G in MDM2, were genotyped using PCR-RFLP and ARMS-PCR respectively. Results:Our analyses revealed that the allele and genotype frequencies of the TP53 R72P polymorphism were not significantly different between the cases and controls (p=0.41, p=0.40 respectively). Also, no significant differences were found in the allelic (p=0.46) and genotypic (p=0.78) distribution of MDM2 309 T>G polymorphism between patients and controls.Conclusion:The results of this study indicate that polymorphisms of TP53 and MDM2 genes are unlikely to contribute to the pathogenesis of male infertility with spermatogenetic failure.

show abstract

Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The frequency of TP53 R72P and MDM2 309T>G polymorphisms in Iranian infertile men with spermatogenetic failure: A case-control study

Abadi

Bami

Golzadeh

et al. 2018

IJRM

View full text Add to dashboard Cite

show abstract

“…A recent meta-analysis by Chan et al also did not observe any significant association of the p53 polymorphism Arg allele with azoospermic males. 22 Similar studies that were conducted on infertile men did not find any association with azoospermic men 20,21 as all the above three studies were not subgrouped and thus no clear association of TP53 codon 72 polymorphism with idiopathic infertility.…”

Section: Discussionmentioning

confidence: 69%

Role of TP53 Gene Polymorphism in Male Infertility

Govindhasamy¹,

Govindhasamy²,

Vanga³

et al. 2021

International Journal of Infertility &Amp; Fetal Medicine

View full text Add to dashboard Cite

Introduction:The TP53 gene is located on chromosome 17p13.1.P53 gene considered as the guardian of the genome belongs to a threemembered gene family p53, p63, and p73. 1 p53 plays a vital role in human cancer and whose mutation was observed in nearly 50% of cancer all around the world. In the present study, genotype distribution was assessed in 147 infertile males, fertile males, and the associations of TP53 Arg72Pro polymorphism with hormonal and seminal parameters were investigated. Materials and methods: A total of 147 infertility men and 150 fertile men were taken for the study. Polymerase chain reaction (PCR) was carried out to amplify the exon 4 of the human p53 CODON 72 genotyping was performed by restriction fragments length polymorphism (RFLP). Results: In summary, the AA genotype and the A allele are significantly associated with azoospermic men when compared to fertile men. Conclusion:The study found preliminary evidence demonstrated that the TP53 gene Arg72 Pro polymorphism contributes significant association to male infertility. Aim and objective: To analyze the association of p53 gene polymorphism in male infertility cases in the study population.

show abstract

“…Researchers have found that women carrying BRCA1 pathogenic mutations demonstrated poorer ovarian responses to controlled ovarian stimulation protocols and lower anti-Müllerian hormone (AMH) levels compared to healthy controls [20][21][22]. Other studies focusing on TP53 (P53) have failed to show an association with infertility in both females and males [23][24][25][26][27]. Thus, while there seems to be a clear connection between TSGs and infertility in model systems, it has yet to be rigorously addressed in humans.…”

Section: Introductionmentioning

confidence: 99%

The potential impact of tumor suppressor genes on human gametogenesis: a case-control study

Hershlag

Peyser

Bristow

et al. 2019

J Assist Reprod Genet

View full text Add to dashboard Cite

Purpose To study the incidence of tumor suppressor gene (TSG) mutations in men and women with impaired gametogenesis. Methods Gene association analyses were performed on blood samples in two distinct patient populations: males with idiopathic male infertility and females with unexplained diminished ovarian reserve (DOR). The male study group consisted of men with idiopathic azoospermia, oligozoospermia, asthenozoospermia, or teratozoospermia. Age-matched controls were men with normal semen analyses. The female study group consisted of women with unexplained DOR with anti-Müllerian hormone levels ≤ 1.1 ng/mL. Controls were age-matched women with normal ovarian reserve (> 1.1 ng/mL). Results Fifty-seven male cases (mean age = 38.4; mean sperm count = 15.7 ± 12.1; mean motility = 38.2 ± 24.7) and 37 agematched controls (mean age = 38.0; mean sperm count = 89.6 ± 37.5; mean motility = 56.2 ± 14.3) were compared. Variants observed in CHD5 were found to be enriched in the study group (p = 0.000107). The incidence of CHD5 mutation c.*3198_*3199insT in the 3′UTR (rs538186680) was significantly higher in cases compared to controls (p = 0.0255). 72 DOR cases (mean age = 38.7; mean AMH = 0.5 ± 0.3; mean FSH = 11.7 ± 12.5) and 48 age-matched controls (mean age = 37.6; mean AMH = 4.1 ± 3.0; mean FSH = 7.1 ± 2.2) were compared. Mutations in CHD5 (c.-140A>C), RB1 (c.1422-18delT, rs70651121), and TP53 (c.376-161A>G, rs75821853) were found at significantly higher frequencies in DOR cases compared to controls (p ≤ 0.05). In addition, 363 variants detected in the DOR patients were not present in the control group. Conclusion Unexplained impaired gametogenesis in both males and females may be associated with genetic variation in TSGs. TSGs, which play cardinal roles in cell-cycle control, might also be critical for normal spermatogenesis and oogenesis. If validated in larger prospective studies, it is possible that TSGs provide an etiological basis for some patients with impaired gametogenesis.

show abstract

No association ofTP53 codon 72 SNP with male infertility: a study in a Chinese population and a meta-analysis

Cited by 5 publications

References 24 publications

The frequency of TP53 R72P and MDM2 309T>G polymorphisms in Iranian infertile men with spermatogenetic failure: A case-control study

The frequency of TP53 R72P and MDM2 309T>G polymorphisms in Iranian infertile men with spermatogenetic failure: A case-control study

Role of TP53 Gene Polymorphism in Male Infertility

The potential impact of tumor suppressor genes on human gametogenesis: a case-control study

Contact Info

Product

Resources

About