No association of maternal vitamin E intake with higher risk of cardiovascular malformations in children: a population-based case–control study

Szilasi, Mária; Bártfai, Liza; Bártfai, Zoltán; Bánhidy, Ferenc; Czeizel, Andr̀ew E.

doi:10.1177/2042098611406946

Cited by 5 publications

(5 citation statements)

References 29 publications

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“…The doses far exceeding the RDA have not proved to be harmful in previous studies [21], though recently a higher risk of cardiovascular malformations was reported after the high dose of VET in early pregnancy [22]. However, this finding was not confirmed in the population-based Hungarian case-control study [23].…”

Section: Discussioncontrasting

confidence: 53%

Birth Outcomes of Pre-Eclamptic Pregnant Women With Vitamin E Supplementation A Population-Based Study

Bártfai¹,

Czeizel²,

Bánhidy³

2011

Open Drug Saf J

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Abstract:Objectives. To study the efficacy of vitamin E supplementation for the reduction of preterm birth/low birthweight newborns in pre-eclamptic pregnant women. Design. Comparison of the rate of preterm birth and low birthweight in pre-eclamptic pregnant women with or without vitamin E treatment. Setting. Hungarian Case-Control Surveillance System of Congenital Abnormalities, 1980Abnormalities, -1996. Population. Newborn infants in Hungarian population. Methods. Medically recorded pre-eclampsia and birth outcomes of pregnant women were evaluated. Main outcome measures. Preterm birth, low birthweight. Results. There was no lower incidence of pre-eclampsia after vitamin E treatment. Pregnant women with pre-eclampsia and without vitamin E treatment had a higher rate of preterm births (10.4% vs. 9.3%) and low birthweight newborns (7.8% vs. 5.6%) than the reference sample of 34,928 pregnant women without pre-eclampsia and without vitamin E treatment. The newborns of 936 pregnant women with pre-eclampsia and without vitamin E treatment had higher rate of preterm birth (10.4% vs. 8.6%; OR with 95% CI: 0.8, 0.7-0.9) than 81 pregnant women with pre-eclampsia but with vitamin E treatment. However, the rate of low birthweight newborns was somewhat but not significantly higher (8.6% vs. 7.8%; OR with 95 CI: 1.1, 0.8-1.4) in pregnant women with pre-eclampsia and with vitamin E treatment. There was very high rate of threatened abortion (45.7% vs. 15.3%) and threatened preterm delivery (27.2% vs. 13.5%) in 81 preeclamptic pregnant women with vitamin E treatment compared to the reference group. Conclusions. Vitamin E treatment reduced the rate of preterm birth in pregnant women with pre-eclampsia but not the rate of low birthweight newborns.

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Section: Discussioncontrasting

confidence: 53%

Birth Outcomes of Pre-Eclamptic Pregnant Women With Vitamin E Supplementation A Population-Based Study

Bártfai¹,

Czeizel²,

Bánhidy³

2011

Open Drug Saf J

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“…In the scientific literatures, there appears to be some conflicting information regarding the safety of multivitamin use in pregnancy. For instance, one study reports that maternal periconceptional intake of vitamin E is associated with congenital heart defects (CHDs), while another study reports that Vitamin E intake during pregnancy does not carry any risk of birth abnormalities . Also, it has been reported that women with excessive serum copper concentrations have a significantly increased risk of having offspring with a CHD, whereas, a low maternal zinc status might have a correlation with CHD .…”

Section: Discussionmentioning

confidence: 99%

“…For instance, one study reports that maternal periconceptional intake of vitamin E is associated with congenital heart defects (CHDs), 29 while another study reports that Vitamin E intake during pregnancy does not carry any risk of birth abnormalities. 30 Also, it has been reported that women with excessive serum copper concentrations have a significantly increased risk of having offspring with a CHD, whereas, a low maternal zinc status might have a correlation with CHD. 31 In a similar report, it was stated that within the normal range of maternal serum zinc and copper concentrations, there is no variation in risk of neural tube defects but women with very high serum zinc levels may have an increased risk of neural tube defects.…”

Section: The Impact Of Low Iron Intake During Pregnancy and Poor Compmentioning

confidence: 99%

Drug‐related teratogenic and pathologic causes of birth defects in a tertiary hospital in Southwestern Nigeria

Offor

Awodele

Oshikoya

2019

Pharmacology Res & Perspec

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Birth defects are important causes of neonatal morbidity and mortality. A good understanding of the etiology is a vital step toward developing improved treatment and preventive strategies. We conducted an audit of medical records of newborns with birth abnormalities in a tertiary hospital over a 10‐year period, using a Pro forma designed to collect information on obstetric history, antenatal history, sociodemographics of parents, and the type of birth abnormality. Of the 180 medical records reviewed, female babies were 92 (51.1%) and male babies were 86 (47.8%). The mean age of the fathers was 38.2 + 6.2, and mothers 31.8 + 4.9. Majority 115 (63.9%) of the mothers had records of acute illnesses, and 23 (12.8%) chronic illnesses during pregnancy. Unspecified febrile illness 44 (38.3%), malaria 40 (34.8%), typhoid 8 (6.9%), hypertension 13 (56.5%), pregestational diabetes 4 (17.4%), and HIV 3 (13.0%) were the commonest maternal pathologies. Most of the documented birth abnormalities were Down's syndrome 34 (15.2%); congenital hydrocephalus 32 (14.3%); acyanotic congenital heart defect 30 (13.4%); deformity of the digits 26 (11.6%); and ventricular septal defect 20 (8.9%). The prevalence of maternal pathologies calls for concern, as these may be implicated in birth defects, therefore should be further investigated in future studies.

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“…e use of vitamin E, although generally considered "healthy," may be harmful to the pregnancy outcome by disrupting the physiological oxidative gestational state and is consequently not recommended to prevent preeclampsia [157]. In a placebo-controlled, doubleblind trial, women diagnosed with chronic hypertension or who had a prior history of preeclampsia who received daily doses of vitamin E (400 IU) and vitamin C (1000 mg) had an increased risk of premature rupture of membranes [203], while another study did not confirm the teratogenic effects of the relatively high-dose vitamin E intake in pregnant women [204]. Further studies are needed on the effect and safety of vitamin E for threatened miscarriage and during early pregnancy.…”

Section: Vitamin Supplementsmentioning

confidence: 99%

Complementary and Alternative Medicine for Threatened Miscarriage: Advantages and Risks

Zhou

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Threatened miscarriage is one of the most common complications causing pregnancy loss, and it affects approximately 20% of confirmed pregnancies. More and more women are seeking treatment with complementary and alternative medicine (CAM) for this common complication, and it has been reported that women have had successful pregnancies after threatened miscarriage when being treated with CAM, which mainly includes Chinese herbal medicines, acupuncture, and nutritional supplements as well as psychological interventions and other approaches. However, many experts are concerned about the safety and adverse events of certain CAM approaches in women with threatened miscarriage. Therefore, this review focuses on the status of CAM for threatened miscarriage and presents the potential therapeutic efficacy and safety of CAM based on some clinical and experimental studies. We thus hope to provide some instructive suggestions for the application of CAM for treating threatened miscarriage in the future.

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No association of maternal vitamin E intake with higher risk of cardiovascular malformations in children: a population-based case–control study

Cited by 5 publications

References 29 publications

Birth Outcomes of Pre-Eclamptic Pregnant Women With Vitamin E Supplementation A Population-Based Study

Birth Outcomes of Pre-Eclamptic Pregnant Women With Vitamin E Supplementation A Population-Based Study

Drug‐related teratogenic and pathologic causes of birth defects in a tertiary hospital in Southwestern Nigeria

Complementary and Alternative Medicine for Threatened Miscarriage: Advantages and Risks

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