No causal relationship between <i>Yersinia enterocolitica</i> infection and autoimmune thyroid disease: evidence from a prospective study

Effraimidis, Grigoris; Tijssen, Jan G.P.; Strieder, Thea G. A.; Wiersinga, W.M.

doi:10.1111/j.1365-2249.2011.04399.x

Cited by 24 publications

(10 citation statements)

References 17 publications

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“…Nevertheless, these sera are very useful tools to analyze NGT-type cytoplasmic N-linked protein glycosylation systems. Whether or not N-linked glucose represents the primary antigen that led to these specific (31), and depending on sample and assay method, between 20 and over 90% of subjects showed antibody reactivity against Y. enterocolitica epitopes (32)(33)(34)(35).…”

Section: Discussionmentioning

confidence: 99%

Molecular Analysis of an Alternative N-Glycosylation Machinery by Functional Transfer from Actinobacillus pleuropneumoniae to Escherichia coli

Naegeli

Neupert

Fan

et al. 2014

Journal of Biological Chemistry

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Background: Actinobacillus pleuropneumoniae N-glycosyltransferase is a cytoplasmic glycosyltransferase catalyzing N-glycosylation of polypeptides. Results: In depth analysis of a reconstituted A. pleuropneumoniae glycosylation system in Escherichia coli showed a surprisingly relaxed peptide substrate specificity of N-glycosyltransferase. Conclusion: N-Glycosyltransferase constitutes a general glycosylation system with a preference for autotransporters. Significance: Our study could provide the basis for a novel route for the engineering of N-glycoproteins in bacteria.

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Section: Discussionmentioning

confidence: 99%

Molecular Analysis of an Alternative N-Glycosylation Machinery by Functional Transfer from Actinobacillus pleuropneumoniae to Escherichia coli

Naegeli

Neupert

Fan

et al. 2014

Journal of Biological Chemistry

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“…GH, Graves' hyperthyroidism; HH, Hashimoto's hypothyroidism. (85). Hepatitis C virus (HCV) might be 'the only infectious agent that is clearly associated with an increased risk for autoimmune thyroiditis' (86).…”

Section: Stressmentioning

confidence: 99%

MECHANISMS IN ENDOCRINOLOGY: Autoimmune thyroid disease: old and new players

Effraimidis

Wiersinga

2014

European Journal of Endocrinology

289

196

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The last 10 years have seen some progress in understanding the etiology of autoimmune thyroid disease (AITD). The female preponderance can now be explained -at least in part -by fetal microchimerism and X-chromosome inactivation. The number of identified susceptibility genes for AITD is increasing (among others now including TSHR, TG, HLA, CTLA4, PTPN22, CD40, FCRL3, IL2RA, and FOXP3), but these genes together probably do not explain more than about 10% of the heritability of AITD. As twin studies indicate that genes contribute for 70% of AITD, it follows that there must be many more loci, each of them contributing a little. While the genetic studies have clarified why various autoimmune diseases so often cluster in the same patient, the molecular mechanism of action of these genetic polymorphisms (frequently located in introns) has hardly been explained. Polymorphisms in AITD susceptibility genes may become helpful in clinical practice, e.g. in assessing risk of recurrent Graves' hyperthyroidism (GH) after a course of antithyroid drugs. Moderate alcohol intake decreases the risk on overt GH and overt Hashimoto's hypothyroidism. Current smokers -as well known -are at increased risk for Graves' disease, but -surprisingly -at diminished risk for Hashimoto's thyroiditis. Low selenium and low vitamin D levels might increase the risk of developing AITD, but data are still inconclusive. Current options for preventive interventions in subjects at risk to develop AITD are very limited.

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“…Although no data are available on altered intestinal microbiota composition in patients with Hashimoto's thyroiditis, increased intestinal permeability has been shown to be present [18]. Also, conflicting data on the association between specific subsets of gut microbiota (Yersinia enterocolitica) and the development of Hashimoto's thyroiditis has been reported [19,20]. Along this line, no data on gut microbiota composition are available in hyperthyroidism (Graves' hyperthyroidism, prevalence 400 per 100,000, more females than males, age of onset 20-50 years) which is thought to originate by thyroid auto antibodies that activate and block the TSH-receptor, thereby stimulating thyroid hormone synthesis [21].…”

Section: Endocrinology and Intestinal Microbiota Compositionmentioning

confidence: 93%

Fecal transplant: A safe and sustainable clinical therapy for restoring intestinal microbial balance in human disease?

Vrieze

Groot

Kootte

et al. 2013

Best Practice & Research Clinical Gastroenterology

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No causal relationship between Yersinia enterocolitica infection and autoimmune thyroid disease: evidence from a prospective study

Cited by 24 publications

References 17 publications

Molecular Analysis of an Alternative N-Glycosylation Machinery by Functional Transfer from Actinobacillus pleuropneumoniae to Escherichia coli

Molecular Analysis of an Alternative N-Glycosylation Machinery by Functional Transfer from Actinobacillus pleuropneumoniae to Escherichia coli

MECHANISMS IN ENDOCRINOLOGY: Autoimmune thyroid disease: old and new players

Fecal transplant: A safe and sustainable clinical therapy for restoring intestinal microbial balance in human disease?

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