NO-dependent phototoxicity of Roussin’s black salt against cancer cells

Jańczyk, Agnieszka; Wolnicka-Głubisz, Agnieszka; Chmura, Antonina; Elas, Martyna; Matuszak, Zenon; Stochel, Grażyna; Urbańska, Krystyna

doi:10.1016/j.niox.2004.01.009

Cited by 50 publications

(24 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since several synthetic NO donors such as the nitrobenzene derivatives [34] and Roussin's black salt [35,36] have been shown to induce cell death in cancer cells, we examined whether these DNICs also have toxic effects against mouse melanoma B16-F10 cells in vitro. Using MTT assay, we found all three DNICs displayed cytotoxicity against B16-F10 cells in a dose-dependent manner.…”

Section: Dna Cleavage and Cytotoxicity Of Dnicsmentioning

confidence: 99%

Synergistic antitumor effect of curcumin and dinitrosyl iron complexes for against melanoma cells

Wen

Shiau

et al. 2010

Journal of Organometallic Chemistry

View full text Add to dashboard Cite

Section: Dna Cleavage and Cytotoxicity Of Dnicsmentioning

confidence: 99%

Synergistic antitumor effect of curcumin and dinitrosyl iron complexes for against melanoma cells

Wen

Shiau

et al. 2010

Journal of Organometallic Chemistry

View full text Add to dashboard Cite

“…Human SKMEL-188 melanoma cell line, a gift from Dr Chakraborty, Yale University, was established from a human metastatic melanoma and then maintained in our laboratories as a continuous cell line [67,68]. …”

Section: Methodsmentioning

confidence: 99%

Calcitriol and Calcidiol Can Sensitize Melanoma Cells to Low–LET Proton Beam Irradiation

Podgórska

Drzał

Matuszak

et al. 2018

IJMS

Self Cite

View full text Add to dashboard Cite

Proton beam irradiation promises therapeutic utility in the management of uveal melanoma. Calcitriol (1,25(OH)2D3)—the biologically active metabolite of vitamin D3—and its precursor, calcidiol (25(OH)D3), exert pleiotropic effects on melanoma cells. The aim of the study was to evaluate the effect of both calcitriol and calcidiol on melanoma cell proliferation and their response to proton beam irradiation. Three melanoma cell lines (human SKMEL-188 and hamster BHM Ma and BHM Ab), pre-treated with 1,25(OH)2D3 or 25(OH)D3 at graded concentrations (0, 10, 100 nM), were irradiated with 0–5 Gy and then cultured in vitro. Growth curves were determined by counting the cell number every 24 h up to 120 h, which was used to calculate surviving fractions. The obtained survival curves were analysed using two standard models: linear-quadratic and multi-target single hit. Calcitriol inhibited human melanoma proliferation at 10 nM, while only calcidiol inhibited proliferation of hamster lines at 10 and 100 nM doses. Treatment with either 1,25(OH)2D3 or 25(OH)D3 radio sensitized melanoma cells to low doses of proton beam radiation. The strength of the effect increased with the concentration of vitamin D3. Our data suggest that vitamin D3 may be an adjuvant that modifies proton beam efficiency during melanoma therapy.

show abstract

“…[21] The recent studies in the field of herbal cancer therapy indirectly support and validate the Unani theory of humors particularly Sauda (black bile). Many single drugs, used in Unani system for the disease, have been evaluated for anticancer activity [22][23][24][25][26][27][28][29][30][31][32] and found to be very effective. However, no attention has been paid to elucidate the efficacy of compound formulations.…”

Section: Mus'hil-e-sauda (Purgative Formulation)mentioning

confidence: 99%

“…[13]All ingredients of the formulation, viz. Halela Siyah, [22,23]Aftimoon, [24,25]Ustokhuddus, [26]KharbaqSiyah, [27][28][29]Milh-e-Nafti [30][31] and Ghariqoon [32]except Bisfaij have been reported to have significant anticancer and cytotoxic effects by various in-vivo and in-vitro studies.…”

Section: Effective Compound Unani Formulations For Evacuation Of Morbmentioning

confidence: 99%

Cancer perception in Unani medicine - Conceptual analysis

Ahmed¹,

Ansari²,

anwar³

et al. 2016

Spatula DD

View full text Add to dashboard Cite

SUMMARYCancer has emerged as a major public health problem worldwide as well as in developing countries. With the cancer incidence further rising, it poses a huge public health and economic challenge. Although widespread research for management of cancer has been going on and present treatment causes so many adverse effects with enormous financial implication, a huge unconsummated need of better intervention is to be explored that has no or less side effects, easily available and above all cost effective in cancer treatment. Unani physicians have not only described the concept of Sartan which literally mean cancer but also cited its management through different regimen which remains unexplored. Linkage of cancer to erratic life style and hereditary factors had been quoted by Unani scholar's way back in 12 th century itself. The recent studies in the field of herbal cancer therapy indirectly support and validate the Unani theory of humors particularly Sauda (black bile). Many single drugs, used in Unani system for the disease, have been evaluated for anticancer activity and found to be very effective. However, no attention has been paid to elucidate the efficacy of compound formulations which needs to be scientifically validated. It is defined as Warm Salabat (hard inflammation) with lesion and their tributaries filled by Madda Saudavia (morbid melancholic humour). The main cause of Sartan (cancer) is stated to be morbid Sauda which is formed by Sauda-e-Ahtraqia (combustion of sauda) after Ahtraq( combustion) of Sauda. The principles of its management include Ilaj-bid-Dawa (drug therapy), Ilaj-bilGhiza (dietotherapy), Ilaj-bit-Tadbeer (regimenal therapy) and Ilaj-bil-Yad (surgery). The future strategies for research in Unani medicine are to validate these therapies by undertaking in vitro, in vivo and clinical studies as adjuvant or in palliative care.Keywords: Sartan, Unani medicine, Cancer ÖZET Kanser, gelişmekte olan ülkelerin yanı sıra dünya genelinde önemli bir halk sağlığı sorunu haline gelmiştir. Kanser insidansı gittikçe artarak, halk sağlığı ve ekonomi için tehdit haline gelmektedir. Kanser tedavisi için yaygın araştırmalar sürmesine ve mevcut tedavi muazzam mali etkileri ile çok olumsuz etkilere neden olmasına rağmen, daha az yan etkiye sahip, kolay erişilebilir ve her şeyden önce maliyet-etkin yeni tedavi yaklaşımlarına ihtiyaç devam etmektedir. Unani doktorlar, sadece kanser anlamına gelen Sartan kavramını tanımlamakla kalmayıp henüz açıklanamayan olan farklı yöntemlerle tedavi yollarını da gösterdiler. Kanser ve düzensiz yaşam tarzı arasındaki ilişki Unani bilim çevrelerince 12. yüzyılda ortaya kondu. Bitkisel kanser tedavisi alanında yapılan son çalışmalar, Unani safralar teorisini dolaylı olarak desteklemekte ve doğrulamaktadır (özellikle de Sauda (kara safra)). Unani sisteminde kanser tedavisinde kullanılan tekli ilaçların birçoğu antikanser etkinliği açısından değerlendirildi ve çok etkili olduğu bulundu. Bununla birlikte, bileşik halinde kullanılan çeşitli formülasyonların etkinliğini bilimsel o...

show abstract

NO-dependent phototoxicity of Roussin’s black salt against cancer cells

Cited by 50 publications

References 30 publications

Synergistic antitumor effect of curcumin and dinitrosyl iron complexes for against melanoma cells

Synergistic antitumor effect of curcumin and dinitrosyl iron complexes for against melanoma cells

Calcitriol and Calcidiol Can Sensitize Melanoma Cells to Low–LET Proton Beam Irradiation

Cancer perception in Unani medicine - Conceptual analysis

Contact Info

Product

Resources

About