NO Dismutase Activity of Seven‐Coordinate Manganese(II) Pentaazamacrocyclic Complexes

Filipović, Miloš R.; Duerr, Katharina; Mojović, Miloš; Simeunović, Vladica; Zimmermann, Robert A.; Niketić, Vesna

doi:10.1002/anie.200801325

Cited by 33 publications

(22 citation statements)

References 29 publications

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“…This response was also independent of the GC-cGMP-PKG axis but reversed by application of reducing agents, suggesting that NO had a direct effect on ASIC probably through oxidation of cysteine residues. With respect to the GC and cGMP-independent pronociceptive actions of NO donors, one must consider that the mitochondrial superoxide dismutase also acts as NO dismutase producing the highly reactive nitroxyl anion (NO Ϫ ) which nitrosylates thiol groups in proteins (e.g., critical cysteines in TRPA1) creating posttranslational modifications of potentially sustained functional effect (197).…”

Section: Mechanisms Of Peripheral Pronociceptive Actions Of Nitric Oxidementioning

confidence: 99%

Sensory and Signaling Mechanisms of Bradykinin, Eicosanoids, Platelet-Activating Factor, and Nitric Oxide in Peripheral Nociceptors

Pethő

Reeh

2012

Physiological Reviews

244

200

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Peripheral mediators can contribute to the development and maintenance of inflammatory and neuropathic pain and its concomitants (hyperalgesia and allodynia) via two mechanisms. Activation or excitation by these substances of nociceptive nerve endings or fibers implicates generation of action potentials which then travel to the central nervous system and may induce pain sensation. Sensitization of nociceptors refers to their increased responsiveness to either thermal, mechanical, or chemical stimuli that may be translated to corresponding hyperalgesias. This review aims to give an account of the excitatory and sensitizing actions of inflammatory mediators including bradykinin, prostaglandins, thromboxanes, leukotrienes, platelet-activating factor, and nitric oxide on nociceptive primary afferent neurons. Manifestations, receptor molecules, and intracellular signaling mechanisms of the effects of these mediators are discussed in detail. With regard to signaling, most data reported have been obtained from transfected nonneuronal cells and somata of cultured sensory neurons as these structures are more accessible to direct study of sensory and signal transduction. The peripheral processes of sensory neurons, where painful stimuli actually affect the nociceptors in vivo, show marked differences with respect to biophysics, ultrastructure, and equipment with receptors and ion channels compared with cellular models. Therefore, an effort was made to highlight signaling mechanisms for which supporting data from molecular, cellular, and behavioral models are consistent with findings that reflect properties of peripheral nociceptive nerve endings. Identified molecular elements of these signaling pathways may serve as validated targets for development of novel types of analgesic drugs.

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Section: Mechanisms Of Peripheral Pronociceptive Actions Of Nitric Oxidementioning

confidence: 99%

Sensory and Signaling Mechanisms of Bradykinin, Eicosanoids, Platelet-Activating Factor, and Nitric Oxide in Peripheral Nociceptors

Pethő

Reeh

2012

Physiological Reviews

244

200

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“…or 4?) cations that stem from their potential applications as molecular magnets [1][2][3], in biochemistry [4,5] and homogeneous catalysis [6,7] due to its intriguing inherent nature and various oxidation states including 2?, 3?, 4?, 6? to 7?.…”

Section: Inroductionmentioning

confidence: 99%

Synthesis, structures and magnetic properties of three metal-organic frameworks containing manganese(II)

Shi

Reis

Brandão

et al. 2010

Transition Met Chem

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Two new Mn(II) coordination polymers formed with molecular formula [Mn(H 2 O) 2 (HBTC)Á(H 2 O)] 1 and [Mn(H 2 O) 2 (4,4 0 bipy)(HBTC) 2 ]Á(H4,4 0 bipy) 2 2, where BTC = 1,2,4-benzenetricarboxylate and 4,4 0 bipy = 4,4 0 bipydine, have been synthesized via hydrothermal approach and characterized by single crystal X-ray diffraction techniques. 1 is composed of Mn-H 2 O-Mn 1D chains and further the chains are linked by HBTC ligands to form a 2D network in the ab plane; 2 is constructed by Mn-4,4 0 bipyMn 1D chains along the b direction with Mn 2? ions coordinated to H 2 BTC and water as terminal ligands to form a 2D network. We also prepared a third compound with the molecular formula of [Mn(H 2 O)(HBTC)Á(H 2 O)] which has been recently structurally reported elsewhere. The magnetic properties of the three compounds have been studied in detail under variable temperatures. InroductionAn increasing interest has taken place in crystal engineering of metal-organic frameworks (MOFs, sometimes known as coordination polymers) or clusters containing manganese (2?, 3? or 4?) cations that stem from their potential applications as molecular magnets [1-3], in biochemistry [4, 5] and homogeneous catalysis [6,7] due to its intriguing inherent nature and various oxidation states including 2?, 3?, 4?, 6? to 7?. In order to construct manganese-based molecular magnets, chemists tend to use short bridging ligands such as O 2-, (OH) -, N 3 -, (CN) -and (SCN) - [1-3, 8, 9] to link Mn cations since the short Mn-Mn contact benefits the magnetic exchange between adjacent metal atoms.From the point view of crystal engineering, the structures and properties of metal organic framework compounds are determined not only by the nature of the metal centers as nodes but also by the functional organic ligands as linkers. When multidentate chelating ligands are employed to link metal cations, their versatile coordination modes are able to build new structural topologies and so provide new compounds which lead to new properties.

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“…This way, the role of NO is preserved, and subsequent formation of peroxynitrite is prevented (which can additionally be removed by porphyrintype of SOD mimics) (3,19,68). Because of this main dogma, only few studies tested a direct reaction of the SOD mimics with NO (20,21,56,63). Since our previous findings showed that manganese-SOD could react with NO through a dismutation mechanism (23), we studied in detail the reaction of penta-azamacrocyclic SOD mimics with NO in vitro (20) and on cellular models (21).…”

mentioning

confidence: 99%

“…Because of this main dogma, only few studies tested a direct reaction of the SOD mimics with NO (20,21,56,63). Since our previous findings showed that manganese-SOD could react with NO through a dismutation mechanism (23), we studied in detail the reaction of penta-azamacrocyclic SOD mimics with NO in vitro (20) and on cellular models (21). We observed that these complexes catalyze NO dismutation, that is, generation of reactive nitrosonium (NO + ) and nitroxyl (NO -/HNO) species; the former being able to cause S-nitrosylation of protein thiols and the latter their oxidation (66).…”

mentioning

confidence: 99%

Redox Modulation of HMGB1-Related Signaling

Janko

Filipović

Muñoz

et al. 2014

Antioxidants & Redox Signaling

141

140

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Significance: In the cells' nuclei, high-mobility group box protein 1 (HMGB1) is a nonhistone chromatin-binding protein involved in the regulation of transcription. Extracellularly, HMGB1 acts as a danger molecule with properties of a proinflammatory cytokine. It can be actively secreted from myeloid cells or passively leak from any type of injured, necrotic cell. Increased serum levels of active HMGB1 are often found in pathogenic inflammatory conditions and correlate with worse prognoses in cancer, sepsis, and autoimmunity. By damaging cells, superoxide and peroxynitrite promote leakage of HMGB1. Recent Advances: The activity of HMGB1 strongly depends on its redox state: Inflammatory-active HMGB1 requires an intramolecular disulfide bond (Cys23 and Cys45) and a reduced Cys106. Oxidation of the latter blocks its stimulatory activity and promotes immune tolerance. Critical Issues: Reactive oxygen and nitrogen species create an oxidative environment and can be detoxified by superoxide dismutase (SOD), catalase, and peroxidases. Modifications of the oxidative environment influence HMGB1 activity. Future Directions: In this review, we hypothesize that manipulations of an oxidative environment by SOD mimics or by hydrogen sulfide are prone to decrease tissue damage. Both the concomitant decreased HMGB1 release and its redox chemical modifications ameliorate inflammation and tissue damage. Antioxid. Redox Signal. 20, 1075-1085.

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NO Dismutase Activity of Seven‐Coordinate Manganese(II) Pentaazamacrocyclic Complexes

Cited by 33 publications

References 29 publications

Sensory and Signaling Mechanisms of Bradykinin, Eicosanoids, Platelet-Activating Factor, and Nitric Oxide in Peripheral Nociceptors

Sensory and Signaling Mechanisms of Bradykinin, Eicosanoids, Platelet-Activating Factor, and Nitric Oxide in Peripheral Nociceptors

Synthesis, structures and magnetic properties of three metal-organic frameworks containing manganese(II)

Redox Modulation of HMGB1-Related Signaling

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