No effect of ultraviolet radiation on blood pressure and other cardiovascular risk factors

Scragg, Robert; Wishart, J H; Stewart, Alistair; Ofanoa, Malakai; Kerse, Ngaire; Dyall, Lorna; Lawes, Carlene M.M.

doi:10.1097/hjh.0b013e328349666d

Cited by 40 publications

(33 citation statements)

References 43 publications

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“…Scragg et al [37,39] reported no effect of vitamin D supplementation on blood pressure [37] and no effect of ultraviolet radiation on blood pressure [39]. Jorde et al [36] observed no effect of supplementation on blood pressure in overweight subjects except for a slight increase.…”

Section: Discussionmentioning

confidence: 99%

“…Randomized controlled trials (RCTs) of the effect of vitamin D supplementation or UV radiation (to improve the vitamin D status) on the lipid profile [17,22,36,37] and blood pressure [36,37,38,39,40] have been divergent. Two meta-analyses of vitamin D supplementation found weak evidence to support a small effect of vitamin D on blood pressure [41,42].…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D Status and Changes in Cardiovascular Risk Factors: A Prospective Study of a General Population

et al. 2012

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Objectives: A low vitamin D level has been associated with increased cardiovascular disease risk but possible mechanisms remain unclear. We investigated the association between vitamin D levels and 5-year changes in blood pressure, lipid profile and incidence of the metabolic syndrome, hypertension and hypercholesterolemia. Methods: A random sample of 6,784 individuals aged 30–60 years from a general population was investigated in the Inter99 study in 1999–2001. Vitamin D (serum 25-hydroxyvitamin D) was measured at baseline by high-performance liquid chromatography, and 4,330 individuals participated at the 5-year follow-up and were included in the present study. Results: The median baseline vitamin D concentration was 48.0 nmol/l. In multivariable linear regression analyses, a 10 nmol/l higher baseline level of vitamin D was associated with a decrease in triglycerides and very low density lipoprotein cholesterol by 0.52 (p = 0.03) and 0.66% (p = 0.005), respectively. In multivariable logistic regression analyses, the odds ratios per 10 nmol/l higher baseline vitamin D level were 0.95 (p < 0.05) and 0.94 (p = 0.01) for the development of the metabolic syndrome and hypercholesterolemia, respectively. There was no association between vitamin D and blood pressure. Conclusions: An optimal vitamin D status may influence cardiovascular health by changing the lipid profile in a favorable direction and decreasing the incidence of the metabolic syndrome.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Vitamin D Status and Changes in Cardiovascular Risk Factors: A Prospective Study of a General Population

et al. 2012

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“…For systolic blood pressure the difference between the highest and lowest vitamin D quintile was on the borderline of statistical significance (P ¼ 0.045). In a randomized clinical trial, Scragg et al 39 found no evidence whatsoever that a UVB-induced rise in plasma 25-(OH) D levels had any effect on arterial blood pressure in a group of normotensive men and women. It must also be noted that in none of the major studies suggesting that low 25-(OH)D is related to hypertension had data been adjusted for a potent confounder, i.e., dietary calcium intake, which can lower diastolic blood pressure in healthy adults, but has much greater effects on systolic blood pressure in patients with mild to moderate hypertension.…”

Section: Multiple Sclerosismentioning

confidence: 98%

Vitamin D insufficiency and chronic diseases: Hype and reality

Peterlik

2012

Food Funct.

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In recent years an increasing number of observational studies have suggested that a low vitamin D status contributes to the development of all sorts of chronic diseases. In reality, however, studies that had been adequately controlled for confounding factors ruled out any link between vitamin D insufficiency and, for example, metabolic disorders, arterial hypertension, multiple sclerosis or cognitive dysfunction. Furthermore, a role of vitamin D insufficiency in autoimmune diseases is evident only in animal models but has not yet been established in humans. In respect to many malignancies, vitamin D insufficiency is only one out of many risk factors and its specific impact on disease incidence has never been assessed. There is convincing evidence, however, that vitamin D insufficiency is a major risk factor for osteoporosis, colorectal and breast cancer as well as for cardiovascular disease and mortality. However, it is debatable that circulating 25-hydroxyvitamin D concentrations of 100-150 nmol l(-1) are required for optimal health outcomes. These are overestimates which would afford to raise vitamin D intake to 4000 IU day(-1). In reality, high doses of vitamin D can cause serious health problems because of the U-shaped dose-response relationships that exist in some cases. Data from large cohort studies clearly indicate that serum 25-(OH)D concentrations around 50 nmol l(-1) are sufficient to minimize the risk of osteoporotic fractures, colorectal and breast cancer, and cardiovascular mortality. The fact that the risk-reducing potential of vitamin D depends on adequate calcium nutrition is widely ignored. I here summarize the evidence that efficient disease prevention does not require intake of more vitamin D and calcium than currently recommended for maintaining optimal bone health.

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“…63,104 However, a lasting effect was not observed beyond the window of treatment. 63,101,103 These anti-hypertensive effects of UVA radiation were independent of a change in vitamin D status, and instead may have been dependent on the release of nitric oxide from preformed skin stores. 63 Some protective effects of UVB on signs of type-2 diabetes have been reported.…”

Section: 5mentioning

confidence: 99%

“…93 Indeed, whole body exposure to UVB radiation lowered blood pressure in hypertensive subjects by ~5 mmHg, 101,102 but had no effect in normotensive adults. 102,103 Acute exposure to sub-erythemal UVA radiation lowered blood pressure in healthy (normotensive) young adults. 63,104 However, a lasting effect was not observed beyond the window of treatment.…”

Section: 5mentioning

confidence: 99%

Ultraviolet radiation, vitamin D and the development of obesity, metabolic syndrome and type-2 diabetes

Gorman

Lucas

Allen-Hall

et al. 2017

Photochem Photobiol Sci

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No effect of ultraviolet radiation on blood pressure and other cardiovascular risk factors

Abstract: Exposure to ultraviolet B did not lower blood pressure. Our results suggest that if vitamin D protects against cardiovascular disease, it involves some mechanism other than blood pressure.

Cited by 40 publications

References 43 publications

Vitamin D Status and Changes in Cardiovascular Risk Factors: A Prospective Study of a General Population

Vitamin D Status and Changes in Cardiovascular Risk Factors: A Prospective Study of a General Population

Vitamin D insufficiency and chronic diseases: Hype and reality

Ultraviolet radiation, vitamin D and the development of obesity, metabolic syndrome and type-2 diabetes

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