No effects of androgen receptor gene CAG and GGC repeat polymorphisms on digit ratio (2D:4D): a comprehensive meta-analysis and critical evaluation of research

Voracek, Martin

doi:10.1016/j.evolhumbehav.2014.05.009

Cited by 51 publications

(58 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Moreover, there is no direct association between mother's and fetus's testosterone serum levels (van de Beek et al, 2004), which suggests that maternal hormonal environment during pregnancy is not associated with fetus's 2D:4D (related to developmental androgen concentration) (but see Manning et al, 1999). 2D:4D's sensitivity to maternal testosterone was also previously suggested to be related to the Xlinked androgen receptor gene (Manning et al, 2003), but this hypothesis has been criticized (Voracek and Dressler, 2009) and is not supported by a meta-analytic reviews (H€ onekopp, 2013;Voracek, 2014). Voracek (2014) suggested that the 2D:4D value is not related to variants of the X-linked androgen receptor gene and proposed several others explanations, i.e., a lack of family correlation patterns indicating X-linked inheritance or a lack of greater intrasex 2D:4D variability among men.…”

Section: Discussionmentioning

confidence: 92%

“…2D:4D's sensitivity to maternal testosterone was also previously suggested to be related to the Xlinked androgen receptor gene (Manning et al, 2003), but this hypothesis has been criticized (Voracek and Dressler, 2009) and is not supported by a meta-analytic reviews (H€ onekopp, 2013;Voracek, 2014). Voracek (2014) suggested that the 2D:4D value is not related to variants of the X-linked androgen receptor gene and proposed several others explanations, i.e., a lack of family correlation patterns indicating X-linked inheritance or a lack of greater intrasex 2D:4D variability among men. Moreover, two large genome-wide association studies also did not confirm any links between the androgen receptor gene and Medland et al, 2010).…”

Section: Discussionmentioning

confidence: 93%

See 1 more Smart Citation

Digit ratio (2D:4D) does not correlate with daily 17β‐estradiol and progesterone concentrations in healthy women of reproductive age

Klimek

Galbarczyk

Colleran

et al. 2015

American J Hum Biol

View full text Add to dashboard Cite

This study shows, for the first time in a large sample of women of reproductive age, that 2D:4D is not a predictor of adult women's sex hormone concentration. The lack of relationship may be because 2D:4D might be genetically determined and is not related to maternal nutritional environment during fetal development. These results support the hypothesis that, in contrast to the nutritional quality of the fetal environment, the fetal hormonal environment (reflected by 2D:4D) does not determine reproductive physiology in later life.

show abstract

Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 93%

Digit ratio (2D:4D) does not correlate with daily 17β‐estradiol and progesterone concentrations in healthy women of reproductive age

Klimek

Galbarczyk

Colleran

et al. 2015

American J Hum Biol

View full text Add to dashboard Cite

show abstract

“…Thus, is it possible that chromosomal sex-determination systems are somehow related to digit ratio patterns? The latest research of Dressler (2009) andVoracek (2014) may sugest that a correlation between digit ratio and sex chromosomes exists. Their studies have revealed that in humans 2D:4D is heritable only through male lines, and hence is correlated only with Y chromosomes.…”

Section: Discussionmentioning

confidence: 99%

Females Have Larger Ratio of Second‐to‐Fourth Digits Than Males in Four Species of Salamandridae, Caudata

Kaczmarski

Kubicka

Tryjanowski

et al. 2015

The Anatomical Record

View full text Add to dashboard Cite

Digit ratio (2D:4D) denotes the relative length of the second and fourth digits. It is considered to be a suitable biomarker of the in utero balance of fetal sex hormones, which affect early development of individua ls behavioral and morphological characteristics. In recent decades, digit ratio attracted a great attention in biology and psychology. However, for unmasking the biological basis of the phenomenon, extensive studies on nonhuman animals are necessary. Despite it was hypothesized that digit ratio is well conserved in all Tetrapoda, and there exist studies on mammals, birds, and reptiles, there are only two such study on anuran amphibians. Therefore, the aim of this study is to investigate the 2D:4D in the most basal salamanders, Caudata. We have studied digit ratio in four species of newts: Triturus cristatus, Mesotriton alpestris, Lissotriton montandoni, and Lissotriton vulgaris, using museum collection. We used computerized measuring of each limbs photos. We have found out that, in M. alpestris, females 2D:4D of all four limbs were significantly larger than in males. In L. montandoni and L. vulgaris, only 2D:4D of rear limbs significantly differed, in females being larger. In T. cristatus, digit ratios of males and females did not statistically differ. Thus, the results confirmed our hypothesis that at least in M. alpestris, L. montandoni, and L. vulgaris, females seem to have larger 2D:4D comparing to males, the pattern known from most mammals and opposite to birds, reptiles and anuran amphibians.

show abstract

“…Putative cognitive differences between left-and right-handers have long been of interest (see Beaton, 1985;Willems et al, 2014) but differences related to other aspects of behaviour, such as alcohol consumption (Bakan, 1973;London, 1987;1990 but see Denny, 2011, smoking (Harburg, Feldstein & Papsdorf, 1978), sleep duration (Hicks, Pellegrini & Hawkins, 1979) and dream frequency (Schredl, Beaton, Henley-Einion & Blagrove, 2013;2014) have also been reported. Coren (1994) considered that left-and right-handers differ in temperament and personality.…”

Section: Permanent Repository Linkmentioning

confidence: 99%

Handedness and behavioural inhibition system/behavioural activation system (BIS/BAS) scores: A replication and extension of Wright, Hardie, and Wilson (2009)

Beaton

Kaack

Corr

2015

Laterality: Asymmetries of Body, Brain and Cognition

View full text Add to dashboard Cite

. (2015). Handedness and behavioural inhibition system/behavioural activation system (BIS/BAS) scores: A replication and extension of Wright, Hardie, and Wilson (2009). Laterality, 20(5), pp. 585-603. doi: 10.1080Laterality, 20(5), pp. 585-603. doi: 10. /1357650X.2015 This is the accepted version of the paper.This version of the publication may differ from the final published version. Handedness has been of interest to neuropsychologists for over a century, largely because of its association with asymmetry of hemispheric function (Beaton, 2003; Ocklenburg, Best, Arning, Peterburs & Güntürkün, 2014). In many, probably most, cognitive and behavioural studies lefthanders are excluded with the intention of minimising heterogeneity with respect to the cerebral representation of function or behaviour. Recently, however, a strong plea has been made to include left-handers in these studies as they "represent a substantial portion of the human population and therefore left-handedness falls within the normal range of human diversity" (Willems, Van der Haegen, Fisher & Francks, 2014). If this plea is heeded, then in studies involving left-handers it will be necessary to understand how, if at all, they differ from right-handers (see also Hancock & Bever, 2013). Permanent repository linkPutative cognitive differences between left-and right-handers have long been of interest (see Beaton, 1985;Willems et al., 2014) but differences related to other aspects of behaviour, such as alcohol consumption (Bakan, 1973;London, 1987;1990 but see Denny, 2011, smoking (Harburg, Feldstein & Papsdorf, 1978), sleep duration (Hicks, Pellegrini & Hawkins, 1979) and dream frequency (Schredl, Beaton, Henley-Einion & Blagrove, 2013;2014) have also been reported. Coren (1994) considered that left-and right-handers differ in temperament and personality. One aspect of personality/behaviour that has received considerable attention is anxiety.On the basis of a questionnaire administered to a group of 14-17 year old girls attending a classifying centre at what was then called an "approved" school (i.e. for adolescents with emotional and behavioural difficulties), Orme (1970) found that a greater proportion of 23 left-handers (defined by writing hand) showed high levels of emotional instability as compared with 277 right-handers. This study was criticised by Hicks & Pellegrini (1978) Dillon (1989) reported a significant correlation among 34 male but not 44 female college students between scores on a questionnaire assessing students' worries and scores on a General Laterality Scale. Using the Edinburgh Handedness Inventory (EHI), Merkelbach, de Ruiter and Olff (1989) compared the handedness of 77 anxiety disorder patients with handedness in a healthy control 6 group and found no evidence of a relationship between left-handedness and clinically diagnosed anxiety.In a recent study Lyle, Chapman and Hatton (2013) Previously they had found (Wright, Hardie & Wilson, 2009) that left-handers reported themselves to have higher BIS scores than right-hande...

show abstract

No effects of androgen receptor gene CAG and GGC repeat polymorphisms on digit ratio (2D:4D): a comprehensive meta-analysis and critical evaluation of research

Cited by 51 publications

References 56 publications

Digit ratio (2D:4D) does not correlate with daily 17β‐estradiol and progesterone concentrations in healthy women of reproductive age

Digit ratio (2D:4D) does not correlate with daily 17β‐estradiol and progesterone concentrations in healthy women of reproductive age

Females Have Larger Ratio of Second‐to‐Fourth Digits Than Males in Four Species of Salamandridae, Caudata

Handedness and behavioural inhibition system/behavioural activation system (BIS/BAS) scores: A replication and extension of Wright, Hardie, and Wilson (2009)

Contact Info

Product

Resources

About